One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses.
Abstract: Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum. The purpose of this manuscript is to disseminate findings from a workshop on the development of translational regenerative medicine in the equine field. Five themes emerged: stem cell characterization and tenogenic differentiation; interactions between mesenchymal stem cells, other cells and the environment; scaffolds and cell packaging; blood- and bone marrow-based regenerative medicines; clinical use of regenerative therapies. Evidence gained through the use of regenerative medicine applications in the horse should continue to translate to the human patient, bringing novel regenerative therapies to both humans and horses.
Publication Date: 2020-08-18 PubMed ID: 32808582DOI: 10.2217/rme-2019-0143Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article is about the development and clinical use of regenerative medicine therapies in equine health, presenting the advancements and challenges of this field which can also contribute to human health.
Overview of Regenerative Medicine
- The study focuses on the field of regenerative medicine, which is often applied in human and equine athletes for treatment and recovery. It outlines potential therapies which include stem cells, adipose tissue, plasma, marrow concentrate, and serum.
- The paper explores the use of these therapies in horses, offering an insight into how treatments that have been successful in regenerative equine medicine could be applied to human health as well.
Key Themes Explored
- The research puts forth five main themes that emerged during the development of translational regenerative medicine, applied in the equine field. These are stem cell characterization and tenogenic differentiation, interactions between different cells and the environment, scaffolds and cell packaging, blood- and bone marrow-based regenerative medicines, and clinical use of regenerative therapies.
- These themes broadly cover an array of important areas in this increasingly evolving field of study, touching on both the technical science behind regenerative therapies and their practical application in a clinical setting.
Translation to Human Health
- The study’s main objective is to build a knowledge-bridge between the success of regenerative medicine in equine health and its potential benefits for human health.
- It suggests that the findings from successful regenerative therapies in horses can be used to develop novel therapies in human medicine, further expanding the potential applications and effectiveness of this particular field of medicine.
Conclusion
- The research concludes that the continuous application of regenerative medicine in equine health will be crucial for deriving evidence that can be successfully translated for human patients, thus enabling the development of new and effective regenerative therapies for both humans and horses alike.
Cite This Article
APA
Fortier LA, Goodrich LR, Ribitsch I, Schnabel LV, Shepard DO, Van de Walle GR, Watts AE, Whealands Smith RK.
(2020).
One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses.
Regen Med, 15(6), 1775-1787.
https://doi.org/10.2217/rme-2019-0143 Publication
Researcher Affiliations
- Department of Clinical Sciences, Cornell University, Ithaca, NY 14543, USA.
- Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
- Veterinary Tissue Engineering and Regenerative Medicine lab, Vienna Veterinary School, Vienna, Austria.
- Department of Clinical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
- Arthrex, Naples, FL 34108, USA.
- Department of Clinical Sciences, Cornell University, Ithaca, NY 14543, USA.
- Large Animal Clinical Studies, Texas A&M University, TX 77840, USA.
- Department of Clinical Sciences & Services, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts. AL9 7TA, UK.
MeSH Terms
- Animals
- Cell Differentiation
- Congresses as Topic
- Horse Diseases / therapy
- Horses
- Mesenchymal Stem Cell Transplantation / methods
- Mesenchymal Stem Cells / cytology
- One Health
- Regenerative Medicine
Citations
This article has been cited 3 times.- Knott LE, Fonseca-Martinez BA, O'Connor AM, Goodrich LR, McIlwraith CW, Colbath AC. Current use of biologic therapies for musculoskeletal disease: A survey of board-certified equine specialists. Vet Surg 2022 May;51(4):557-567.
- Cequier A, Sanz C, Rodellar C, Barrachina L. The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses. Animals (Basel) 2021 Mar 25;11(4).
- Cequier A, Vázquez FJ, Vitoria A, Bernad E, Fuente S, Serrano MB, Zaragoza MP, Romero A, Rodellar C, Barrachina L. The systemic cellular immune response against allogeneic mesenchymal stem cells is influenced by inflammation, differentiation and MHC compatibility: in vivo study in the horse. Front Vet Sci 2024;11:1391872.
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