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Home / Equine Research Bank / Biomater Transl / Osteoarthritis animal models for biomaterial-assisted osteoc...
Biomaterials translational2022; 3(4); 264-279; doi: 10.12336/biomatertransl.2022.04.006

Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration.

Abstract: Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of tissue engineering and regenerative medicine in terms of OCD treatment, the utility of an optimal OCD animal model is crucial for assessing the effects of implanted biomaterials on the repair of damaged osteochondral tissues. Currently, the most frequently used in vivo animal models for OCD regeneration include mice, rats, rabbits, dogs, pigs, goats, sheep, horses and nonhuman primates. However, there is no single "gold standard" animal model to accurately recapitulate human disease in all aspects, thus understanding the benefits and limitations of each animal model is critical for selecting the most suitable one. In this review, we aim to elaborate the complex pathological changes in osteoarthritic joints and to summarise the advantages and limitations of OCD animal models utilised for biomaterial testing along with the methodology of outcome assessment. Furthermore, we review the surgical procedures of OCD creation in different species, and the novel biomaterials that promote OCD regeneration. Above all, it provides a significant reference for selection of an appropriate animal model for use in preclinical in vivo studies of biomaterial-assisted osteochondral regeneration in osteoarthritic joints.
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Publication Date: 2022-12-28 PubMed ID: 36846505PubMed Central: PMC9947734DOI: 10.12336/biomatertransl.2022.04.006Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the use of various animal models to study and assess the effects of implanted biomaterials for the repair of damaged osteochondral tissues within the context of osteoarthritis.

Introduction

  • The study is about identifying the best animal model to study the regeneration of osteochondral defects (OCD) specifically in the early stages of osteoarthritis.
  • This is critical for understanding tissue engineering and regenerative medicine interventions associated with OCD treatment.
  • The challenge lies in there not being a singular “gold standard” animal model that effectively and thoroughly represents the complexity and characteristics of the human disease.

Animal Models for Osteochondral Defects

  • Various in vivo animal models like mice, rats, rabbits, dogs, pigs, goats, sheep, horses, and nonhuman primates are commonly used for studying OCD regeneration.
  • Each of these animal models has its own unique advantages and limitations, and choosing the most suitable one is an important step in the research process.

Pathological Changes and Methodologies

  • The study provides an in-depth look at the complex pathological changes that occur in osteoarthritic joints.
  • It also discusses the methodologies used to assess the outcomes of the tests performed on the selected animal models.

Surgical Procedures and Novel Biomaterials

  • Aside from focusing on the animal models, the paper also reviews the surgical procedures used to create OCD in different species.
  • Part of the review is dedicated to the examination of the novel biomaterials that have shown promise in promoting OCD regeneration.

Conclusion

  • Ultimately, the information gathered from this study can serve as an important reference for selecting the most appropriate animal model for preclinical in vivo studies of biomaterial-assisted osteochondral regeneration in osteoarthritic joints.

Cite This Article

APA
Wang Y, Chen Y, Wei Y. (2022). Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration. Biomater Transl, 3(4), 264-279. https://doi.org/10.12336/biomatertransl.2022.04.006

Publication

Biomaterials translational
ISSN: 2096-112X
NlmUniqueID: 9918351163606676
Country: China
Language: English
Volume: 3
Issue: 4
Pages: 264-279

Researcher Affiliations

Wang, Yi
  • Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Chen, Yangyang
  • Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Wei, Yulong
  • Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

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