FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Research in veterinary science2020; 130; 240-246; doi: 10.1016/j.rvsc.2020.03.026

Ozone therapy in veterinary medicine: A review.

Abstract: Ozone (O) is a triatomic form of oxygen. As O rapidly dissociates into water and releases a reactive form of oxygen that may oxidize cells, the gas mixture of O/O is used in medicine. ATP is widely available for cellular activity. O can be administered via the systemic and local routes. Although O is known as one of the most powerful oxidants, it also promotes antioxidant enzymes. Additionally, it stimulates some of the cells of the immune system and inactivates pathogens, including bacteria, fungi, yeasts, protozoa, and viruses. Owing to these activities, O is used to improve several diseases, both in human and in veterinary medicine. Considering the wide scope of O application, the aim of this review was to reiterate the mechanisms of action of O and its utilization in different mammalian species (bovine, ovine-caprine, equine, canine, porcine).
Copyright © 2020 Elsevier Ltd. All rights reserved.
Get Full Text
Publication Date: 2020-03-25 PubMed ID: 32234614DOI: 10.1016/j.rvsc.2020.03.026Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reviews the use of ozone therapy in treating various diseases in different mammal species in veterinary medicine.

Overview of Ozone Therapy

Ozone (O) is a triatomic form of oxygen. In the context of medicine, a gas mixture of ozone and oxygen is used due to ozone’s ability to rapidly dissociate into water while releasing a reactive form of oxygen that has the potential to oxidize cells. This unique characteristic enables ozone to be widely used in medical practices both for humans and animals.

  • The dissociated oxygen form is known to provide ATP, an energy source for cellular activities. This feature explains why ozone can be efficiently delivered systemically or locally to the patients.
  • Despite its powerful oxidant properties, ozone surprisingly promotes antioxidant enzymes. This dual-role contributes to the regulation and balance of oxidative stress within the body.
  • In addition, ozone shows promising potential in stimulating immune cells and neutralizing various pathogens such as bacteria, fungi, yeasts, protozoa, and viruses. This underlines ozone’s role in immune responses and infectious disease control.

Ozone Therapy in Veterinary Medicine

Ozone therapy has been applied in veterinary medicine to treat a range of diseases across various mammal species.

  • In bovine and ovine-caprine species, ozone therapy is used to improve their health condition which ultimately enhances productivity.
  • In equine medicine, ozone is utilized in both prevention and treatment of diseases, showing particularly effective performance in respiratory and joint diseases.
  • The use of ozone therapy in dogs has proved to effectively support the immune system and fight against infectious diseases.
  • Similar to the previous species, ozone application in porcine medicine aids in overall illness prevention and treatment, contributing to improved well-being and increased growth.

Conclusion of the Review

In conclusion, the review highlights the beneficial effects of ozone therapy in veterinary medicine. Although several findings support its use, further research in this field is required for better understanding and potentially more effective applications of ozone in animal health.

Cite This Article

APA
Sciorsci RL, Lillo E, Occhiogrosso L, Rizzo A. (2020). Ozone therapy in veterinary medicine: A review. Res Vet Sci, 130, 240-246. https://doi.org/10.1016/j.rvsc.2020.03.026

Publication

Research in veterinary science
ISSN: 1532-2661
NlmUniqueID: 0401300
Country: England
Language: English
Volume: 130
Pages: 240-246
PII: S0034-5288(20)30056-4

Researcher Affiliations

Sciorsci, R L
  • Department of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy. Electronic address: raffaeleluigi.sciorsci@uniba.it.
Lillo, E
  • Department of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
Occhiogrosso, L
  • Department of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.
Rizzo, A
  • Department of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km. 3, 70010 Valenzano, BA, Italy.

MeSH Terms

  • Animals
  • Antioxidants
  • Cattle
  • Cattle Diseases / drug therapy
  • Dog Diseases / drug therapy
  • Dogs
  • Goat Diseases / drug therapy
  • Goats
  • Horse Diseases / drug therapy
  • Horses
  • Oxidants
  • Oxidation-Reduction
  • Ozone / administration & dosage
  • Ozone / therapeutic use
  • Prodrugs
  • Sheep
  • Sheep Diseases / drug therapy
  • Swine
  • Swine Diseases / drug therapy

Citations

This article has been cited 15 times.
  1. Dos Santos TG, Orlandin JR, de Almeida MF, Scassiotti RF, Oliveira VC, Santos SIP, Pereira VM, Pinto PAF, Mariano CG, Ambrósio CE. Ozone therapy: protocol for treating canine parvovirus infection. Braz J Vet Med 2023;45:e004622.
    doi: 10.29374/2527-2179.bjvm004622pubmed: 36819842google scholar: lookup
  2. Orlandin JR, Machado LC, Ambrósio CE, Travagli V. Ozone and its derivatives in veterinary medicine: A careful appraisal. Vet Anim Sci 2021 Sep;13:100191.
    doi: 10.1016/j.vas.2021.100191pubmed: 34401601google scholar: lookup
  3. Morgoglione ME, Bosco A, Ciuca L, Pepe P, Coles GC, Cringoli G, Rinaldi L. In Vitro Evaluation of Ozonated Water Treatment on the Viability of Eimeria Oocysts and Giardia Cysts from Water Buffaloes: A Proof-of-Concept Study. Vet Sci 2021 Jun 18;8(6).
    doi: 10.3390/vetsci8060115pubmed: 34207325google scholar: lookup
  4. Nguyen Ngoc D, Valverde Piedra JL, Milczak A, Szponder T, Drzewiecka B, Pyzerska A, Kowalczyk M, Fila M, Tomaszewska E, Ahluwalia A, Wessely-Szponder J. Mild Ozone-Induced Oxidative Stress Modulates the Activity and Viability of Porcine Neutrophils and Monocytes. Animals (Basel) 2026 Jan 8;16(2).
    doi: 10.3390/ani16020193pubmed: 41594382google scholar: lookup
  5. Remoli G, Inguscio CR, Boschi F, Tabaracci G, Malatesta M, Cisterna B. Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study. Eur J Histochem 2026 Jan 26;70(1).
    doi: 10.4081/ejh.2026.4440pubmed: 41586752google scholar: lookup
  6. Bungărdean D, Pall E, Daradics Z, Popescu M, Tripon MA, Lupșan AF, Crecan CM, Morar IA, Nicolescu A, Bora FD, Marcus I. In Vitro Effects of PRP, Ozonized PRP, Hyaluronic Acid, Paracetamol, and Polyacrylamide on Equine Synovial Fluid-Derived Mesenchymal Stem Cells. Life (Basel) 2025 Oct 4;15(10).
    doi: 10.3390/life15101558pubmed: 41157231google scholar: lookup
  7. Repciuc CC, Vișan GA, Teleky BE, Pintea A, Novac CȘ, Oros NV. Physico-Chemical and Antimicrobial Evaluation of Ozonated Olive Oil Produced with a Medical-Grade Generator for Veterinary Purposes. Microorganisms 2025 Aug 18;13(8).
    doi: 10.3390/microorganisms13081932pubmed: 40871436google scholar: lookup
  8. Malatesta M, Carton F. Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy. Nanomaterials (Basel) 2025 Aug 3;15(15).
    doi: 10.3390/nano15151188pubmed: 40801726google scholar: lookup
  9. Malatesta M, Tabaracci G, Pellicciari C. Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action. Int J Mol Sci 2024 Nov 25;25(23).
    doi: 10.3390/ijms252312657pubmed: 39684369google scholar: lookup
  10. Silva LP, Portela RW, Machado MC, Canuto GAB, Costa-Neto JM, Carvalho VMP, Sá HC, Damasceno KA, Souza VRC, Coelho CS, Estrela-Lima A. Ozone Therapy in the Integrated Treatment of Female Dogs with Mammary Cancer: Oxidative Profile and Quality of Life. Antioxidants (Basel) 2024 May 30;13(6).
    doi: 10.3390/antiox13060673pubmed: 38929112google scholar: lookup
  11. Melanie P, Niola C, Plataroti I, Mancini S, Fratini F. Use of Ozone in Veterinary Dentistry as an Alternative to Conventional Antibiotics and Antiseptics. Vet Sci 2024 Apr 3;11(4).
    doi: 10.3390/vetsci11040163pubmed: 38668430google scholar: lookup
  12. Slavinskienė G, Grigonis A, Ivaškienė M, Sinkevičienė I, Andrulevičiūtė V, Ivanauskas L, Juodžentė D, Ramanauskienė K, Daunoras G. A Comparative Study of the Chemical Properties and Antibacterial Activity of Four Different Ozonated Oils for Veterinary Purposes. Vet Sci 2024 Apr 1;11(4).
    doi: 10.3390/vetsci11040161pubmed: 38668428google scholar: lookup
  13. Braga CQ, Zambrano CG, Dos Santos Bermann C, Milech A, Ianiski LB, Soares MP, Pötter L, de Avila Botton S, Pereira DIB. In vitro and ex vivo anti-Pythium insidiosum potential of ozonated sunflower oil. Braz J Microbiol 2024 Mar;55(1):867-873.
    doi: 10.1007/s42770-023-01173-1pubmed: 37999913google scholar: lookup
  14. Lillo E, Pellegrini F, Rizzo A, Lanave G, Zizzadoro C, Cicirelli V, Catella C, Losurdo M, Martella V, Tempesta M, Camero M. In Vitro Activity of Ozone/Oxygen Gaseous Mixture against a Caprine Herpesvirus Type 1 Strain Isolated from a Goat with Vaginitis. Animals (Basel) 2023 Jun 8;13(12).
    doi: 10.3390/ani13121920pubmed: 37370430google scholar: lookup
  15. Ye XY, Li XL, Li YG, Li YC, Xiao HT, Zhang J, Zhao XK, Xia CD, Tian SM, Feng K. [Clinical effects of medical ozone autologous blood transfusion combined with Xingnaojing in the treatment of septic encephalopathy in burns]. Zhonghua Shao Shang Za Zhi 2021 Jun 20;37(6):568-574.
    doi: 10.3760/cma.j.cn501120-20200330-00204pubmed: 34139826google scholar: lookup
Subscribe to our newsletter
Join 99,727 horse owners like you who receive our email updates on horse health and nutrition.