Papillomaviral skin diseases of humans, dogs, cats and horses: A comparative review. Part 2: Pre-neoplastic and neoplastic diseases.
Abstract: Papillomaviruses (PVs) are well recognized to cause pre-neoplastic and neoplastic diseases in humans. Similarly, there is increasing evidence that PVs play a significant role in the development of pre-neoplastic and neoplastic diseases of the haired skin of dogs and cats, and the mucosa of horses. As the mechanisms by which PVs cause neoplasia are well studied in humans, it is valuable to compare the PV-induced neoplasms of humans with similar PV-associated neoplasms in the companion animal species. In the second part of this comparative review, the pre-neoplastic and neoplastic diseases thought to be caused by PVs in humans, dogs, cats, and horses are described. This includes PV-induced cutaneous plaques, cutaneous squamous cell carcinomas (SCCs) and mucosal SCCs within the four species. The review concludes with a discussion about the potential use of vaccines to prevent PV-induced diseases of dogs, cats, and horses.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Publication Date: 2022-09-21 PubMed ID: 36152994DOI: 10.1016/j.tvjl.2022.105898Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article reviewed the role of Papillomaviruses (PVs) in causing pre-neoplastic and neoplastic diseases in humans, dogs, cats, and horses, and discussed the potential use of vaccines for preventing these diseases.
Background
- The article sits on the premise that Papillomaviruses (PVs) are well known to cause diseases that can lead to cancer in humans such as pre-neoplastic and neoplastic diseases.
- It acknowledges the growing evidence that also suggests a significant role of PVs in the development of similar diseases but in dogs, cats, and horses, especially in the haired skin and mucosa.
PV-Induced Neoplasms
- This paper takes a comparative review approach, putting side by side PV-induced neoplasms in humans and these companion animal species, in the understanding that the mechanisms through which PVs cause cancer are well studied in humans.
- It, therefore, reveals the relationship between these viruses and the onset of such diseases across the species.
Symptoms and Illnesses
- Specifically, part two of this comparative review describes the pre-neoplastic and neoplastic diseases that result from PVs in not just humans, but also dogs, cats, and horses–in one swoop providing a comprehensive coverage of the impact of PVs across the species.
- It discriminates into cutaneous plaques, cutaneous squamous cell carcinomas (SCCs), and mucosal SCCs within the four species; unpacking a broad spectrum of diseases that PVs can cause.
Potential Use of Vaccines
- The review doesn’t stop at describing these diseases but also looks into potential solutions.
- It concludes with a section discussing the potential use of vaccines to prevent the diseases that are induced by PVs in the covered species – dogs, cats, and horses.
Summary
- Basically, this research article provides a comprehensive and comparative review of the diseases caused by Papillomaviruses in humans, dogs, cats, and horses, offering insights into potential vaccines that could be used to prevent these diseases.
Cite This Article
APA
Munday JS, Knight CG, Luff JA.
(2022).
Papillomaviral skin diseases of humans, dogs, cats and horses: A comparative review. Part 2: Pre-neoplastic and neoplastic diseases.
Vet J, 288, 105898.
https://doi.org/10.1016/j.tvjl.2022.105898 Publication
Researcher Affiliations
- Pathobiology, School of Veterinary Science, Massey University, Palmerston North, New Zealand. Electronic address: j.munday@massey.ac.nz.
- Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
- Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / veterinary
- Cat Diseases
- Cats
- DNA, Viral
- Dog Diseases
- Dogs
- Horse Diseases
- Horses
- Humans
- Papillomaviridae / genetics
- Skin Neoplasms / veterinary
- Virus Diseases / veterinary
Conflict of Interest Statement
Declaration of Competing Interest None of the authors of this paper has a financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.
Citations
This article has been cited 3 times.- Parisi F, Fonti N, Millanta F, Freer G, Pistello M, Poli A. Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis.. Infect Agent Cancer 2023 Jun 29;18(1):40.
- Medeiros-Fonseca B, Faustino-Rocha AI, Medeiros R, Oliveira PA, Gil da Costa RM. Canine and feline papillomaviruses: an update.. Front Vet Sci 2023;10:1174673.
- Munday JS, Hunt H, Orbell G, Pfeffer H. Detection of a Novel Papillomavirus Type within a Feline Cutaneous Basal Cell Carcinoma.. Vet Sci 2022 Dec 1;9(12).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
