Papillomavirus infection and squamous cell carcinoma in horses.
Abstract: Squamous cell carcinoma (SCC) is a common disease that seriously impairs the health and welfare of affected horses and other equids. In humans, almost all cervical carcinomas, a high percentage of anogenital SCCs and a subset of SCCs of the head and neck are caused by high-risk human papillomavirus (hrHPV) infection. Since hrHPV-induced human cancers and equine SCC have similar cytological and histopathological features, it has been hypothesised that equine SCCs could also be induced by papillomaviruses. This review provides an overview of the current evidence for an aetiological association between papillomavirus infections and equine SCCs and SCC precursor lesions. SCC of apparently papillomavirus-unrelated aetiology are also discussed, as are recent advances in equine SCC prophylaxis.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Publication Date: 2017-05-31 PubMed ID: 28671071DOI: 10.1016/j.tvjl.2017.05.007Google Scholar: Lookup
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- Journal Article
- Review
Summary
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The research article investigates the potential link between papillomavirus infections and the initiation of Squamous cell carcinoma (SCC) among horses, as well as possible prevention steps based on recent advancements.
Linkage between Papillomavirus and Squamous Cell Carcinoma in Horses
- This research explores the hypothesis that equine SCCs may be induced by papillomaviruses, similar to the induction of human cancers such as cervical carcinomas and anogenital SCCs by high-risk human papillomavirus (hrHPV).
- In humans, nearly all cervical cancers, a high percentage of anogenital SCCs, and a subset of SCCs of the head and neck are induced by hrHPV infection. Similar cytological and histopathological features observed in human cancers induced by hrHPV match those found in equine SCC, leading to the hypothesis of the paper.
Review of Current Evidence
- The research analyzes current evidence for an etiological connection between papillomavirus infections and equine SCCs and pre-SCC lesions. This forms the basis for their argument and provides a means to investigate further the potential relationship.
Research on SCC of Unrelated Etiology
- Aside from focusing on the HPV link, the research also discusses SCC cases in horses that appear to have an unrelated etiology to papillomavirus. This is essential to ascertain if all instances of SCC in horses can be linked to papillomavirus or if there are other contributing factors.
Recent Advances in Equine SCC Prophylaxis
- Finally, the research delves into recent advancements in preventive measures for equine SCC. The objective is to thoroughly understand possible preventative steps for SCC, or ways to manage and mitigate the disease among horses.
In conclusion, this research article provides an extensive review and analysis of the possible links between papillomavirus and equine Squamous cell carcinoma. Providing information on the etiology, examination of SCC cases unrelated to papillomavirus, and unpacking recent advancements in preventative techniques, the article sets the stage for further research in this domain.
Cite This Article
APA
Sykora S, Brandt S.
(2017).
Papillomavirus infection and squamous cell carcinoma in horses.
Vet J, 223, 48-54.
https://doi.org/10.1016/j.tvjl.2017.05.007 Publication
Researcher Affiliations
- Research Group Oncology, Equine Clinic, University of Veterinary Medicine, 1210 Vienna, Austria.
- Research Group Oncology, Equine Clinic, University of Veterinary Medicine, 1210 Vienna, Austria. Electronic address: sabine.brandt@vetmeduni.ac.at.
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / veterinary
- Carcinoma, Squamous Cell / virology
- Female
- Genital Neoplasms, Female / veterinary
- Genital Neoplasms, Female / virology
- Genital Neoplasms, Male / veterinary
- Genital Neoplasms, Male / virology
- Horse Diseases / virology
- Horses
- Male
- Papillomavirus Infections / prevention & control
- Papillomavirus Infections / veterinary
- Viral Vaccines
Citations
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