Pathogenicity for horses of original Sagiyama virus, a member of the Getah virus group.
Abstract: Sagiyama virus is a member of the Getah virus group. Its pathogenicity for horses was examined. All the horses infected with the original 4 strains of Sagiyama virus (M6/Mag 33, Mag 121, Mag 132 and Mag 258) developed pyrexia ranging from 39.0 to 40.0 degrees C. Other clinical signs, characterized by eruptions, edema in the hind legs, enlargement of the submandibular lymph node and mild leukopenia, were also manifested. Viremia occurred 1-4 days post-inoculation (p.i.). Virus was recovered from spleen, liver, lung and various lymph nodes of a horse autopsied on Day 4 p.i. The maximum titer of virus (10(6.0) TCID50 g-1) was detected in the inguinal lymph node. Seroconversion was demonstrated in all the infected horses on Day 5 p.i. These clinical signs and virological findings were similar to those of horses infected naturally. The results indicate that Sagiyama virus has pathogenicity for horses and is similar to that of Getah virus.
Publication Date: 1988-08-01 PubMed ID: 2847399DOI: 10.1016/0378-1135(88)90050-8Google Scholar: Lookup
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- Journal Article
Summary
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This research investigates the pathogenic effects of the Sagiyama virus, part of the Getah virus group, on horses. It found that horses infected with the virus display various symptoms and that the virus replicates within their bodies, demonstrating its pathogenicity.
Research Method
- The researchers examined the pathogenicity of the Sagiyama virus in horses, by infecting them with four original strains of the virus (M6/Mag 33, Mag 121, Mag 132, and Mag 258).
- Signs of infection were monitored, including fever, skin eruptions, swelling in the hind legs, enlargement of certain lymph nodes, and mild leukopenia (a decrease in white blood cells).
- The occurrence of Viremia (presence of viruses in the blood) was tracked from days 1 to 4 post-inoculation.
- An autopsy was performed on a horse on the 4th day after inoculation to recover the virus from various organs and lymph nodes.
- The researchers also detected the virus’ maximum titer, or concentration, in an infected horse’s lymph node.
- Seroconversion, or the development of specific antibodies in the blood in response to an infection, was observed on the 5th day post-inoculation.
Key Findings
- All horses infected with the Sagiyama virus strains developed a fever ranging between 39.0 to 40.0 degrees Celcius.
- The clinical signs observed in the infected horses, such as eruptions, hind leg edema, submandibular lymph node enlargement, and mild leukopenia, indicate the pathogenicity of the Sagiyama virus.
- Viremia occurred within 1-4 days after the horses were inoculated with the virus, suggesting that the virus replicates in the horse’s body.
- The virus was successfully recovered from the spleen, liver, lungs, and various lymph nodes of a horse after it was autopsied on the 4th day post-inoculation.
- The maximum concentration of the virus (10(6.0) TCID50 g-1) was found in the inguinal lymph node.
- All the infected horses showed seroconversion on the 5th day after inoculation, indicating their immune response to the virus infection.
Conclusion
- The research concludes that the Sagiyama virus is pathogenic for horses, with clinical signs and virological findings similar to those of infections naturally occurring in horses.
- Given its symptoms and virological findings, the Sagiyama virus’s pathogenicity is similar to that of the Getah virus group.
Cite This Article
APA
Kumanomido T, Kamada M, Wada R, Kenemaru T, Sugiura T, Akiyama Y.
(1988).
Pathogenicity for horses of original Sagiyama virus, a member of the Getah virus group.
Vet Microbiol, 17(4), 367-373.
https://doi.org/10.1016/0378-1135(88)90050-8 Publication
Researcher Affiliations
- Equine Research Institute, Japan Racing Association, Tochigi.
MeSH Terms
- Alphavirus / pathogenicity
- Animals
- Female
- Horse Diseases / blood
- Horse Diseases / microbiology
- Horses
- Male
- Togaviridae Infections / blood
- Togaviridae Infections / microbiology
- Togaviridae Infections / veterinary
- Viremia / veterinary
Citations
This article has been cited 3 times.- Powell LA, Miller A, Fox JM, Kose N, Klose T, Kim AS, Bombardi R, Tennekoon RN, Dharshan de Silva A, Carnahan RH, Diamond MS, Rossmann MG, Kuhn RJ, Crowe JE Jr. Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe 2020 Nov 11;28(5):699-711.e7.
- Powers AM, Brault AC, Shirako Y, Strauss EG, Kang W, Strauss JH, Weaver SC. Evolutionary relationships and systematics of the alphaviruses. J Virol 2001 Nov;75(21):10118-31.
- Brown CM, Timoney PJ. Getah virus infection of Indian horses. Trop Anim Health Prod 1998 Aug;30(4):241-52.
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