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Home / Equine Research Bank / J Vet Med Sci / Pentosan polysulfate regulates hepcidin expression in native...
The Journal of veterinary medical science2022; 84(10); 1437-1441; doi: 10.1292/jvms.22-0113

Pentosan polysulfate regulates hepcidin expression in native Mongolian horses.

Abstract: The aim of this study was to investigate the anti-hepcidin effect of pentosan polysulfate (PPS) in Mongolian horses. Twenty-six healthy horses were randomly allocated in to two-groups; one group was treated with a PPS once a week for 4-weeks while another group keeping as placebo. Blood samples at day 0 (D0), before race (BR; day 28) and after race (AR; day 28) were analyzed for serum biochemistry, hepcidin and iron concentrations. Significant reduction of hepcidin was observed at AR in PPS group when compared with BR placebo (P<0.05) and AR placebo (P<0.01). Mean hepcidin concentration difference of D0-BR and BR-AR in PPS was greater than the placebo whereas the iron concentration difference is reduced compared to placebo. Results indicate a novel therapeutic application of PPS as an anti-hepcidin compound to control hepcidin in horses while emphasizing further molecular studies.
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Publication Date: 2022-08-30 PubMed ID: 36047165PubMed Central: PMC9586020DOI: 10.1292/jvms.22-0113Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores the effect of pentosan polysulfate on the regulation of hepcidin (a hormone that controls iron absorption) expression in Mongolian horses. Key findings include the potential therapeutic use of this compound to manage hepcidin levels in these animals.

Objective and Methodology

  • The primary goal of this study was to assess the anti-hepcidin effects of a compound known as Pentosan Polysulfate (PPS) in Mongolian horses.
  • The researchers selected 26 healthy horses and divided them randomly into two groups. One group was treated with PPS once a week for four weeks, while the other group was left untreated and served as a control group, referred to as the placebo.
  • Blood samples were collected at key stages – at the start of the study (Day 0), before a race (Day 28), and after the race (Day 28). These samples were then analyzed to determine changes in hepcidin and iron concentrations, as well as general serum biochemistry.

Results

  • The study found a significant reduction in hepcidin levels in the PPS-treated group after the race, compared to both before the race and after the race in the placebo group. The effect was more pronounced compared to after race placebo (with a p value of less than 0.01) than before race placebo (p value less than 0.05).
  • Moreover, the mean difference in hepcidin concentration from Day 0 to before the race and from before the race to after the race in the PPS-treated group was greater than in the placebo group.
  • Interestingly, the difference in iron concentration between these time periods was less in the PPS group compared to the placebo group. This could potentially mean that PPS might be regulating hepcidin expression, subsequently affecting iron levels.

Conclusion

  • This study presents evidence of an innovative therapeutic application for PPS as an anti-hepcidin compound. It demonstrates that PPS can effectively control hepcidin levels in horses, suggesting potential for managing disorders related to iron absorption in these animals.
  • However, the researchers emphasize the need for more detailed molecular studies to understand the underlying mechanisms behind these observations and validate the potential therapeutic use of PPS.

Cite This Article

APA
Wijekoon S, Tsogbadrakh M, Sunaga T, Wang Y, Mwale C, Kim S, Alimaa D, Okumura M. (2022). Pentosan polysulfate regulates hepcidin expression in native Mongolian horses. J Vet Med Sci, 84(10), 1437-1441. https://doi.org/10.1292/jvms.22-0113

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 84
Issue: 10
Pages: 1437-1441

Researcher Affiliations

Wijekoon, Suranji
  • Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.
Tsogbadrakh, Mijiddorj
  • Department of Veterinary Surgery and Theriogenology, School of Veterinary Medicine, Mongolian University of Life Science, Ulaanbaatar, Mongolia.
Sunaga, Takafumi
  • Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.
Wang, Yanlin
  • Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.
Mwale, Carol
  • Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.
Kim, Sangho
  • Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.
Alimaa, Damdinsuren
  • Department of Veterinary Surgery and Theriogenology, School of Veterinary Medicine, Mongolian University of Life Science, Ulaanbaatar, Mongolia.
Okumura, Masahiro
  • Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido, Japan.

MeSH Terms

  • Animals
  • Horses
  • Iron
  • Pentosan Sulfuric Polyester / pharmacology

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Citations

This article has been cited 2 times.
  1. Satué K, Fazio E, La Fauci D, Medica P. Changes of Hepcidin, Ferritin and Iron Levels in Cycling Purebred Spanish Mares. Animals (Basel) 2023 Mar 31;13(7).
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  2. Smith MM, Melrose J. Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues. Pharmaceuticals (Basel) 2023 Mar 13;16(3).
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