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Home / Equine Research Bank / Equine Vet J / Peritoneal bile acids concentration in adult horses with hep...
Equine veterinary journal2021; 54(5); 914-921; doi: 10.1111/evj.13538

Peritoneal bile acids concentration in adult horses with hepatic and gastrointestinal disorders.

Abstract: Peritoneal bile acids concentration (PBAC) has not been previously reported in horses. A case of liver lobe torsion in which increased PBAC was detected prompted us to study PBAC in horses. Objective: (a) To determine a reference range of PBAC in horses; (b) to compare PBAC from horses with either hepatic or gastrointestinal disease and healthy horses and (c) to assess the prognostic and diagnostic values of PBAC. Methods: Prospective case-control. Methods: Prospective observational clinical study. Bile acids concentrations were measured in both plasma and peritoneal fluid in selected clinical patients with hepatic or gastrointestinal disease (n = 108) and healthy horses (n = 11). Sixty-eight of 108 patients survived to hospital discharge, and the remaining 40 were nonsurvivors. Additionally, other haematological and biochemistry analyses were performed. Results: Sick horses were classified according to diagnosis into hepatic (n = 13), gastrointestinal (GI) obstructive (n = 48) and GI ischaemic-inflammatory (n = 47) groups. The hepatic group had significantly higher PBAC (6.8 [2.3-9.4]; median [IQR]) than the control (1.0 [0.6-1.5]) and GI obstructive groups (1.2 [0.8-1.7] µmol/L; P < .001). Moreover, the GI ischaemic-inflammatory group (3.3 [1.4-5.5]) also had significantly higher values than the control and GI obstructive groups (P < .001). Regarding outcome, the nonsurvivor group (n = 40) had significantly higher median PBAC value than the survivor group (n = 68, 4.1 [1.6-6.5] vs 1.3 [0.8-3]; P < .001). Conclusions: A higher number of horses with abdominal disease is required to confirm the clinical significance of these findings. Conclusions: PBAC may have a role in the diagnosis of hepatic and gastrointestinal disease and as a prognostic tool in horses with abdominal pain.
© 2021 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
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Publication Date: 2021-11-19 PubMed ID: 34743363DOI: 10.1111/evj.13538Google Scholar: Lookup
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  • Journal Article
  • Observational Study
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research is about examining the concentration of bile acids in the peritoneal fluid of horses to establish a reference point and explore its use in diagnosing hepatic and gastrointestinal diseases in horses, as well as its potential prognostic value in determining the outcome of these diseases.

Objective and Methodology of the Study

  • The researchers initially set out to determine a reference range for Peritoneal Bile Acids Concentration (PBAC) in horses. This was prompted by an instance of liver lobe torsion in a horse which exhibited increased PBAC.
  • Their objective also included making a comparative analysis of PBAC in horses with either hepatic or gastrointestinal disease and healthy horses. Additionally, they sought to ascertain the prognostic and diagnostic value of PBAC.
  • The methodology adopted for this study was prospective and observational. The selected clinical patients included horses with hepatic or gastrointestinal disease and healthy horses were used as a control group.
  • The concentration of bile acids was measured in both plasma and peritoneal fluid. Other haematological and biochemistry analyses were also performed.

Results of the Study

  • The study classified sick horses based on diagnosis into hepatic, gastrointestinal obstructive, and gastrointestinal ischaemic-inflammatory groups. It was revealed that the hepatic and the gastrointestinal ischaemic-inflammatory group had significantly higher PBAC than the control and gastrointestinal obstructive groups.
  • Regarding the outcome, horses that did not survive the hospital discharge (nonsurvivor group) showed significantly higher median PBAC value compared to the group that survived (survivor group).
  • The study concluded that a larger sample size of horses with abdominal disease is required to confirm the clinical significance of these findings.

Conclusion and Implication of the Study

  • The research suggests that PBAC might play a role in diagnosing hepatic and gastrointestinal diseases in horses. It may also be useful as a prognosis tool for determining the likely outcome of these diseases by comparing the PBAC levels in the survivor and nonsurvivor groups.
  • This could potentially help with early detection and intervention of these diseases, thereby improving the survival rate. However, the researchers highlighted that a larger sample size would be necessary to consolidate the findings of this initial study.

Cite This Article

APA
Rodríguez-Pozo ML, Armengou L, Viu J, Ríos J, Jose-Cunilleras E. (2021). Peritoneal bile acids concentration in adult horses with hepatic and gastrointestinal disorders. Equine Vet J, 54(5), 914-921. https://doi.org/10.1111/evj.13538

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 54
Issue: 5
Pages: 914-921

Researcher Affiliations

Rodríguez-Pozo, Maria L
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Spain.
Armengou, Lara
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Spain.
Viu, Judit
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Spain.
Ríos, Jose
  • Laboratory of Biostatistics and Epidemiology, Statistics and Methodology Support Unit, IDIBAPS, Hospital Clinic, Barcelona, Spain.
Jose-Cunilleras, Eduard
  • Servei de Medicina Interna Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Spain.
  • Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Spain.

MeSH Terms

  • Animals
  • Ascitic Fluid
  • Bile Acids and Salts
  • Colic / veterinary
  • Gastrointestinal Diseases / diagnosis
  • Gastrointestinal Diseases / veterinary
  • Horse Diseases / diagnosis
  • Horses
  • Liver

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Citations

This article has been cited 1 times.
  1. Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. Biomarkers of Intestinal Injury in Colic. Animals (Basel) 2023 Jan 7;13(2).
    doi: 10.3390/ani13020227pubmed: 36670767google scholar: lookup
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