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Home / Equine Research Bank / Vet Med Int / Peritoneal response to abdominal surgery: the role of equine...
Veterinary medicine international2014; 2014; 279730; doi: 10.1155/2014/279730

Peritoneal response to abdominal surgery: the role of equine abdominal adhesions and current prophylactic strategies.

Abstract: Intra-abdominal adhesions constitute a significant clinical and surgical problem that can lead to complications such as pain and bowel occlusion or subocclusion. These adhesions are frustrating and potentially fatal, representing a major postoperative complication in abdominal surgery. It is estimated that 32% of horses undergoing laparotomy will present clinical symptoms due to adhesions, but the true prevalence is not known because a large proportion of animals with postoperative recurrent colics are medically treated or submitted to euthanasia without necropsy. Adhesions are highly cellular, vascularized, dynamic structures that are influenced by complex signaling mechanisms. Understanding their pathogenesis could assist in applying better therapeutic strategies and in developing more effective antiadhesion products. Currently, there are no definitive strategies that prevent adhesion formation, and it is difficult to interpret the results of existing studies due to nonstandardization of an induction model and evaluation of their severity. The best clinical results have been obtained from using minimally traumatic surgical techniques, anti-inflammatory agents, antimicrobials, anticoagulants, and mechanical separation of serosal surfaces by viscous intraperitoneal solutions or physical barriers. This paper aims to review adhesion formation pathogenesis, guide the understanding of major products and drugs used to inhibit adhesion formation, and address their effectiveness in the equine species.
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Publication Date: 2014-01-20 PubMed ID: 24587939PubMed Central: PMC3918701DOI: 10.1155/2014/279730Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper focuses on the impact of intra-abdominal adhesions in horses post abdominal surgery, detailing their formation, their potential effects, and current attempts at prevention and treatment methods.

Adhesion Formation

  • The article details that intra-abdominal adhesions in horses pose a significant clinical issue following abdominal surgery. These adhesions can lead to severe complications, including pain, bowel occlusion, or subocclusion.
  • Equine adhesions are highly cellular and vascularized structures influenced by complex signaling mechanisms within the body. Understanding their formation is critical in developing improved therapeutic strategies.

Prevalence of Adhesions

  • The paper notes that nearly 32% of horses undergoing laparotomy—an abdominal surgery—present symptoms relating to adhesions. However, the actual prevalence may be higher, given that many animals with symptoms are treated medically or put down without post-mortem examination.

Current Therapeutic Approaches

  • No definitive prevention strategies have been established in dealing with adhesion formation. Various techniques like less traumatic surgical methods, the use of anti-inflammatory drugs, antimicrobials, anticoagulants, and mechanical separation of the organ linings using viscous intra-abdominal solutions or physical barriers have shown some success.
  • Despite these measures, interpreting results from existing studies have been challenging due to the lack of standardized induction models and evaluation of adhesion severity.

Purpose of the Paper

  • The research paper aims to delve into the pathogenesis of adhesion formation, explore the understanding of major products and drugs used to inhibit adhesion formation, and assess their effectiveness in horses.

Cite This Article

APA
Alonso Jde M, Alves AL, Watanabe MJ, Rodrigues CA, Hussni CA. (2014). Peritoneal response to abdominal surgery: the role of equine abdominal adhesions and current prophylactic strategies. Vet Med Int, 2014, 279730. https://doi.org/10.1155/2014/279730

Publication

Veterinary medicine international
ISSN: 2090-8113
NlmUniqueID: 101524203
Country: United States
Language: English
Volume: 2014
Pages: 279730
PII: 279730

Researcher Affiliations

Alonso, Juliana de Moura
  • School of Veterinary Medicine and Animal Science, UNESP, University Estadual Paulista, Botucatu, São Paulo, Brazil.
Alves, Ana Liz Garcia
  • School of Veterinary Medicine and Animal Science, UNESP, University Estadual Paulista, Botucatu, São Paulo, Brazil.
Watanabe, Marcos Jun
  • School of Veterinary Medicine and Animal Science, UNESP, University Estadual Paulista, Botucatu, São Paulo, Brazil.
Rodrigues, Celso Antonio
  • School of Veterinary Medicine and Animal Science, UNESP, University Estadual Paulista, Botucatu, São Paulo, Brazil.
Hussni, Carlos Alberto
  • School of Veterinary Medicine and Animal Science, UNESP, University Estadual Paulista, Botucatu, São Paulo, Brazil.

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