Phagocytic and killing capacities of uterine-derived polymorphonuclear leukocytes from mares resistant and susceptible to chronic endometritis.
Abstract: The host defense competence of uterine-derived polymorphonuclear leukocytes (PMN) from mares considered resistant (grade I uteri) and susceptible (grade III uteri) to chronic endometritis was evaluated for phagocytic and killing (bactericidal) capacities, using a fluorochrome assay. Peripheral blood PMN from noncategorized mares and from grade I and grade III mares were used as controls. Uterine-derived PMN from mares with grade I uteri were functionally competent for phagocytosis and killing of Candida albicans, whereas uterine-derived PMN from mares with grade III uteri had significantly less phagocytic and killing capacities (P greater than or equal to 0.0001). Results of the present study, together with data obtained from chemotactic responsiveness and deformability assays of a previous study, indicated an overall deficiency in the host defense mechanism of uterine-derived PMN from mares with grade III uteri obtained 12 hours after induced Streptococcus zooepidemicus infection. This deficiency may account for the susceptibility of mares with grade III uteri to chronic endometritis.
Publication Date: 1985-09-01 PubMed ID: 3901839
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The research study evaluates the ability of specific white blood cells, derived from the uteruses of horses, to ingest and kill a fungal pollutant. Particularly, the study compares such capacities between horses resistant and susceptible to chronic uterine inflammation.
Objective of Study
- The purpose of this study was to analyze the capability and efficiency of certain white blood cells, officially named as Polymorphonuclear Leukocytes (PMN), derived from the uterus of mares (female horses). The research primarily focused on studying how PMNs from horses that are resistant (grade I) or susceptible (grade III) to chronic endometritis (long-term inflammation of the lining of the uterus) perform in terms of their phagocytic (ability to ingest) and bactericidal (capable of killing bacteria) functions.
Methodology and Control groups
- The study utilized a fluorochrome assay (a test used to measure cellular processes) to examine these capabilities. PMNs from the blood of mares which were not categorized, and from mares with grade I and III uteri were employed as control groups for comparative analysis.
Study Findings
- The research found that the PMNs derived from the uterus of mares with grade I uteri were effective in ingesting and killing the fungus Candida albicans.
- In contrast, those derived from mares with grade III uteri showed substantially lesser phagocytic and bactericidal capabilities.
- This disparity was statistically significant, with a P-value less than or equal to 0.0001, indicating a strong probability that the difference observed was not due to chance.
Conclusions
- The results of the study suggest an overall deficiency in the defense mechanism of PMNs sourced from the uteri of mares with grade III chronic endometritis.
- This deficiency was apparent from data obtained not just from this study, but also from previous ones in which researchers studied the chemotactic responsiveness (ability of cells to move in response to chemical stimulants) and deformability (ability to change shape) of these cells.
- The researchers believe that this deficiency might be the reason why mares with grade III uteri are more susceptible to chronic endometritis.
Cite This Article
APA
Cheung AT, Liu IK, Walsh EM, Miller ME.
(1985).
Phagocytic and killing capacities of uterine-derived polymorphonuclear leukocytes from mares resistant and susceptible to chronic endometritis.
Am J Vet Res, 46(9), 1938-1940.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Candida albicans / immunology
- Chronic Disease
- Disease Susceptibility
- Endometritis / immunology
- Endometritis / veterinary
- Female
- Horse Diseases / immunology
- Horses / immunology
- Neutrophils / immunology
- Phagocytosis
- Spores, Fungal / immunology
- Streptococcal Infections / immunology
- Streptococcal Infections / veterinary
- Uterus / cytology
Grant Funding
- PHS-RR00169 / NCRR NIH HHS
Citations
This article has been cited 4 times.- Khalaf AA, Hussein S, Tohamy AF, Marouf S, Yassa HD, Zaki AR, Bishayee A. Protective effect of Echinacea purpurea (Immulant) against cisplatin-induced immunotoxicity in rats. Daru 2019 Jun;27(1):233-241.
- Malmgren L, Olsson Engvall E, Engvall A, Albihn A. Aerobic bacterial flora of semen and stallion reproductive tract and its relation to fertility under field conditions. Acta Vet Scand 1998;39(2):173-82.
- Troedsson M, Concha C, Einarsson S, Holmberg O. A preliminary study of uterine derived polymorphonuclear cell function in mares with chronic uterine infections. Acta Vet Scand 1990;31(2):187-92.
- Ranjbar Golafshani FZ, Ghaffari Lashkenari E, Kermani F, Abbaszadeh Godarzi S, Mahdavi Omran S. A Unique Case of Fungal Endometritis Caused by Aspergillus quadrilineatus in an Immunocompetent Woman and Literature Review. Clin Case Rep 2025 Feb;13(2):e70146.
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