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Home / Equine Research Bank / J Vet Pharmacol Ther / Pharmacodynamics and plasma concentrations of dexmedetomidin...
Journal of veterinary pharmacology and therapeutics2021; 44(5); 754-765; doi: 10.1111/jvp.12992

Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane-A pilot study.

Abstract: The aim was to determine the effects of vatinoxan on dexmedetomidine plasma concentrations and effects on cardiovascular and intestinal tissue pharmacodynamics. In a prospective randomized study, six horses were premedicated intravenously with dexmedetomidine 3.5 µg kg followed by a constant-rate infusion of 7 µg kg  h (group DEX) and six horses with dexmedetomidine of the same dose (bolus and constant-rate infusion) combined with vatinoxan 130 µg kg followed by 40 µg kg  h (group VAT). Anaesthesia was induced with ketamine and diazepam and maintained with isoflurane. Venous blood samples were withdrawn before and at predefined points in time after drug application. During sedation and anaesthesia, cardiopulmonary variables, gastrointestinal tissue perfusion and oxygenation were recorded. Data were analysed using two-way-ANOVA, unpaired-t-test and Dunnett's-t-test (p < 0.05). Group VAT had significantly higher oxygen delivery and lower oxygen extraction ratio, venous admixture, alveolar dead space and alveolar-arterial-oxygen difference. Tissue perfusion of buccal mucosa was reduced during anaesthesia in group DEX. Plasma concentrations of dexmedetomidine in group VAT (n = 6) and group DEX (n = 5) were comparable between groups. In the present pilot study, co-administration of vatinoxan with dexmedetomidine did not alter plasma concentrations of dexmedetomidine but ameliorated tissue perfusion and global oxygenation variables.
© 2021 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.
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Publication Date: 2021-06-23 PubMed ID: 34159620DOI: 10.1111/jvp.12992Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Veterinary

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study aims to explore the impact of vatinoxan on the plasma concentrations of dexmedetomidine and its effects on cardiovascular and intestinal tissue pharmacodynamics in anaesthetized horses.

Objective of the Study

  • The study was designed to understand the influence of vatinoxan on dexmedetomidine plasma concentrations. The effect of this interaction on cardiovascular and intestinal tissue pharmacodynamics was also examined. Dexmedetomidine is an anesthetic often used in veterinary medicine, while vatinoxan is a medicine used to counteract some unwanted side effects of dexmedetomidine.

Research Methodology

  • In a randomized study, six horses were induced with dexmedetomidine alone and another six horses were induced with a combination of dexmedetomidine and vatinoxan.
  • Anaesthesia was induced with ketamine and diazepam, and sustained with isoflurane.
  • Blood samples were taken before and at various points after the drugs were administered.
  • The variables recorded included cardiopulmonary health, gastrointestinal tissue perfusion, and the amount of oxygen in the blood.
  • Data from the study were then analyzed using statistical methods including two-way Analysis of Variance (ANOVA), unpaired t-test and Dunnett’s t-test.

Key Findings

  • The group of horses that were administered vatinoxan along with dexmedetomidine showed better global oxygenation figures and tissue perfusion, indicating an improvement in blood flow and oxygen uptake in vital tissues.
  • Plasma concentrations of dexmedetomidine were similar in both groups, suggesting that the administration of vatinoxan did not influence dexmedetomidine’s concentration in the plasma.
  • The buccal mucosa tissue perfusion was reduced in the dexmedetomidine group during anaesthesia, implying that vatinoxan protects the tissues from low perfusion states.

Conclusion of the Study

  • The co-administration of vatinoxan with dexmedetomidine did not alter the plasma concentrations of dexmedetomidine.
  • The addition of vatinoxan improved tissue perfusion and oxygenation, suggesting a beneficial interaction that can ameliorate some effects of dexmedetomidine anaesthesia in horses.

Cite This Article

APA
Neudeck S, Twele L, Kopp V, Kästner S. (2021). Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane-A pilot study. J Vet Pharmacol Ther, 44(5), 754-765. https://doi.org/10.1111/jvp.12992

Publication

Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 44
Issue: 5
Pages: 754-765

Researcher Affiliations

Neudeck, Stephan
  • Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Twele, Lara
  • Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Kopp, Veronika
  • Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Kästner, Sabine
  • Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
  • Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

MeSH Terms

  • Anesthetics, Inhalation
  • Animals
  • Dexmedetomidine / pharmacology
  • Horses
  • Isoflurane
  • Pilot Projects
  • Prospective Studies
  • Quinolizines

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Citations

This article has been cited 1 times.
  1. Verhaar N, Kopp V, Pfarrer C, Neudeck S, König K, Rohn K, Kästner S. Alpha(2) Antagonist Vatinoxan Does Not Abolish the Preconditioning Effect of Dexmedetomidine on Experimental Ischaemia-Reperfusion Injury in the Equine Small Intestine. Animals (Basel) 2023 Aug 30;13(17).
    doi: 10.3390/ani13172755pubmed: 37685019google scholar: lookup
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