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Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study.
Abstract: Local photodynamic therapy (PDT) is a novel cancer therapy in veterinary ophthalmology. A prospective pilot study seeking to demonstrate proof of principle and safety for the treatment of equine periocular squamous cell carcinoma (PSCC) was therefore conducted. We hypothesized that surgical excision with adjunctive local PDT is an effective and safe treatment for equine PSCC. Methods: Nine horses (10 eyes) with PSCC were treated with surgical resection, local infiltration of resulting wound beds with 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and irradiation with 665-nm wavelength diode laser. Regular follow-up ophthalmic examinations were performed. Results: Surgical resection and PDT yielded disease-free intervals of 25-68 months in our study horses as of January, 2008. These results were obtained following a single treatment in seven horses and two treatments in one horse. In one horse, carcinoma in situ developed 2.5 months after partial surgical excision and PDT, requiring local excision under standing sedation. Conclusions: Preliminary results suggest that surgical resection and adjunctive local PDT is a safe and effective novel treatment for PSCC in horses. More research is needed before PDT for the treatment of equine PSCC can be adequately compared with other current modalities. Important to future investigations regarding PDT, tumor recurrence rate, length of hospitalization, number of treatment episodes required to effect tumor remission, and total treatment costs should be examined in a controlled manner. Our present results and experiences suggest that this treatment may be useful in the treatment of equine PSCC.
Publication Date: 2008-12-17 PubMed ID: 19046267DOI: 10.1111/j.1463-5224.2008.00643.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research article discusses a pilot study conducted to examine the safety and efficacy of a new treatment for periocular squamous cell carcinoma, a type of cancer, in horses. The treatment combines surgical excision with photodynamic therapy (PDT), a method involving a special drug that becomes active when exposed to light.
Research Objectives and Methodology
The objective of this study was to validate the hypothesis that combining surgical resection with local photodynamic therapy (PDT) is a safe and effective treatment for equine Periocular Squamous Cell Carcinoma (PSCC). The method used was:
- performing surgical removal of as much of the tumor as possible,
- injecting the wound area with a drug known as HPPH,
- and then exposing the area to light of a specific wavelength emitted by a diode laser.
This procedure was carried out on nine horses (involving ten eyes), each suffering from PSCC.
Study Results
The results showed that after undergoing the treatment, the horses remained free of the disease for a period of 25-68 months. This outcome was achieved after a single treatment in seven horses and two treatments in one horse. However, one horse did develop ‘carcinoma in situ’ (CIS) or an early stage of cancer, 2.5 months after partial surgical resection and PDT treatment. This necessitated another round of local excision under sedation.
Conclusions and Future Directions
The findings suggest that through surgical excision coupled with PDT, it is possible to safely and effectively treat PSCC in horses. Nevertheless, to draw comprehensive conclusions, more research is required. Future studies should aim to assess and compare PDT treatment with current treatment procedures for PSCC in horses. It is also important to scrutinise variables like tumor recurrence rate, length of hospital stay, number of treatments required to eliminate the tumor, and the overall treatment costs in a controlled setting. The preliminary results from this pilot study indicate potential for adopting this novel treatment in addressing PSCC in horses.
Cite This Article
APA
Giuliano EA, MacDonald I, McCaw DL, Dougherty TJ, Klauss G, Ota J, Pearce JW, Johnson PJ.
(2008).
Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study.
Vet Ophthalmol, 11 Suppl 1, 27-34.
https://doi.org/10.1111/j.1463-5224.2008.00643.x Publication
Researcher Affiliations
- Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211, USA. giulianoe@missouri.edu
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / drug therapy
- Carcinoma, Squamous Cell / mortality
- Carcinoma, Squamous Cell / surgery
- Carcinoma, Squamous Cell / veterinary
- Combined Modality Therapy / veterinary
- Disease-Free Survival
- Eye Neoplasms / drug therapy
- Eye Neoplasms / mortality
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Horse Diseases / drug therapy
- Horse Diseases / mortality
- Horse Diseases / surgery
- Horses
- Male
- Photochemotherapy / methods
- Photochemotherapy / veterinary
- Pilot Projects
- Prospective Studies
- Treatment Outcome
Citations
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