Physiologic responses and plasma endothelin-1 concentrations associated with abrupt cessation of nitric oxide inhalation in isoflurane-anesthetized horses.
Abstract: To assess physiologic responses and plasma endothelin (ET)-1 concentrations associated with abrupt cessation of nitric oxide (NO) inhalation in isoflurane-anesthetized horses. Methods: 6 healthy adult Standardbreds. Methods: Horses were anesthetized with isoflurane in oxygen and placed in dorsal recumbency. Nitric oxide was pulsed into the respiratory tract for 2.5 hours, and then administration was abruptly discontinued. Just prior to commencement and at cessation of NO administration, and at intervals during a 30-minute period following cessation of NO inhalation, several variables including PaO(2), mean pulmonary artery pressure, venous admixture or pulmonary shunt fraction (Qs/Qt), and plasma ET-1 concentration were recorded or calculated. Results: After cessation of NO inhalation, PaO(2) decreased slowly but significantly (172.7 +/- 29.8 mm Hg to 84.6 +/- 10.9 mm Hg) and Qs/Qt increased slowly but significantly (25 +/- 2% to 40 +/- 3%) over a 30-minute period. Mean pulmonary artery pressure increased slightly (14.0 +/- 1.3 mm Hg to 16.8 +/- 1 mm Hg) over the same time period. No change in serum ET-1 concentration was detected, and other variables did not change or underwent minor changes. Conclusions: The improvement in arterial oxygenation during pulsed inhalation of NO to healthy isoflurane-anesthetized horses decreased only gradually during a 30-minute period following cessation of NO inhalation, and serum ET-1 concentration was not affected. Because a rapid rebound response did not develop, inhalation of NO might be clinically useful in the treatment of hypoxemia in healthy isoflurane-anesthetized horses.
Publication Date: 2008-03-04 PubMed ID: 18312143DOI: 10.2460/ajvr.69.3.423Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article describes a study aimed at understanding the physiological responses and changes in plasma endothelin-1 (ET-1) concentrations that occur when nitric oxide (NO) inhalation is abruptly stopped in horses anesthetized with isoflurane.
Objective of the Study
- The study was designed to assess the change in physiological parameters such as PaO2 (the partial pressure of oxygen), mean pulmonary artery pressure, venous admixture or pulmonary shunt fraction (Qs/Qt), and plasma ET-1 concentration in horses when nitric oxide (NO) inhalation is suddenly ceased.
Methodology
- The study was conducted on six healthy adult standardbred horses that were anesthetized with isoflurane and placed in a dorsal recumbent position.
- Nitric oxide was introduced into the horses’ respiratory tract for a duration of 2.5 hours, after which it was abruptly discontinued.
- Various physiological measures were recorded before, during and after the NO administration. The readings were taken at intervals during the 30 minutes following the cessation of NO inhalation.
Results
- Following the cessation of NO inhalation, the researchers observed a significant, yet gradual, decrease in PaO2 levels, and an increase in Qs/Qt values over a 30-minute period.
- The mean pulmonary artery pressure also showed a slight increase during the same time period.
- There were no detectable changes in the plasma ET-1 concentration, and other variables either remained stable or showed minor changes.
Conclusions
- The study’s findings indicate that the augmentation in arterial oxygenation seen during pulsed inhalation of NO in healthy isoflurane-anesthetized horses declined only gradually over 30 minutes following cessation of NO inhalation. Furthermore, there were no changes observed in plasma ET-1 concentration.
- Because a quick rebound response was not observed, the research suggests that nitric oxide inhalation could prove beneficial in the clinical treatment of hypoxemia (low blood oxygen) in healthy horses anesthetized with isoflurane.
Cite This Article
APA
Grubb TL, Högman M, Edner A, Frendin JH, Heinonen E, Malavasi LM, Frostell CG, Ryden A, Alving K, Nyman GC.
(2008).
Physiologic responses and plasma endothelin-1 concentrations associated with abrupt cessation of nitric oxide inhalation in isoflurane-anesthetized horses.
Am J Vet Res, 69(3), 423-430.
https://doi.org/10.2460/ajvr.69.3.423 Publication
Researcher Affiliations
- Riverview Animal Clinic, Uniontown, WA 99179, USA.
MeSH Terms
- Administration, Inhalation
- Anesthesia, Inhalation / veterinary
- Animals
- Blood Gas Analysis / veterinary
- Blood Pressure / drug effects
- Bronchodilator Agents / administration & dosage
- Endothelin-1 / blood
- Female
- Heart Rate / drug effects
- Horses / blood
- Horses / physiology
- Male
- Nitric Oxide / administration & dosage
- Respiration / drug effects
Citations
This article has been cited 2 times.- Wilkens HL, Neudeck S, Kästner SBR. Nasal and tracheobronchial nitric oxide production and its influence on oxygenation in horses undergoing total intravenous anaesthesia. BMC Vet Res 2022 Apr 11;18(1):134.
- Tucker L, Almeida D, Wendt-Hornickle E, Baldo CF, Allweiler S, Guedes AGP. Effect of 15° Reverse Trendelenburg Position on Arterial Oxygen Tension during Isoflurane Anesthesia in Horses. Animals (Basel) 2022 Feb 1;12(3).
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