Plasma and tissue concentrations of oxytetracycline in the horse after intravenous administration.

The research investigates the concentrations of the antibiotic oxytetracycline (OTC) in horse plasma and tissues after being given intravenously. It suggests that OTC is adequately distributed within the horses’ bodies.

Research Methodology

• The research team involved three clinically healthy horses in their study.
• The horses were each given an intravenous dosage of oxytetracycline (OTC), an antibiotic, at a quantity of 10mg per kilogram of the horse’s body weight.
• The team continuously monitored the plasma OTC concentrations at 30-minute intervals until the 240th minute post-injection (PIM 240).

Data Collection

• At PIM 240, the researchers measured the OTC concentration in the horses’ lung tissue. They discovered the average OTC concentration was 3.96 micrograms per gram of lung tissue (when calculated as wet weight).
• The team similarly measured the OTC concentration in the horses’ kidney tissue at PIM 240. They found the average concentration was significantly higher, at 25.47 micrograms per gram of tissue.
• The researchers also measured the OTC concentration in diluted bronchial fluid at PIM 240, which was found to be 0.288 micrograms per milliliter.

Interpretation and Conclusion

• The researchers were keen to observe how effectively OTC is distributed within the horses’ bodies, as this is crucial for the antibiotic’s efficacy.
• Based on their measurements, the research team concluded that OTC shows satisfactory distribution within horse tissue. This implies that when given intravenously, OTC manages to reach multiple crucial organs and carries out its action effectively.