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Plasma atrial natriuretic peptide concentrations in horses with heart disease: a pilot study.
Abstract: Atrial natriuretic peptide (ANP) is a cardiovascular biomarker that might be useful in assessing the severity of cardiac disease in horses. Plasma ANP concentrations (Cp(ANP)) were compared between horses with heart disease but normal chamber size and function (Group A; n=6), horses with heart disease associated with left atrial (LA) enlargement, LA dysfunction, and/or left ventricular (LV) enlargement (Group B; n=5), and horses with no clinically apparent cardiovascular disease (Group C; n=13). The median (min-max) for Cp(ANP) was significantly higher in Group B (53.5 (36.0-70.7) pg/mL), compared to Group A (12.5 (6.3-19.8) pg/mL) and Group C (13.4 (7.2-34.0) pg/mL). Backwards stepwise multiple linear regression showed that Cp(ANP) in horses with heart disease was related to LA dimensions, but not to LV size, LA function, and LV function. The results indicated that Cp(ANP) in horses might be useful in detecting LA enlargement and that Cp(ANP) could be related to the severity of cardiac disease. Larger prospective studies are necessary to confirm these results.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication Date: 2011-07-22 PubMed ID: 21782487DOI: 10.1016/j.tvjl.2011.06.035Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This study explores the potential use of atrial natriuretic peptide (ANP), a cardiovascular biomarker, in measuring the severity of heart disease in horses. It shows that horses with heart disease associated with an enlarged left atrium have significantly higher concentrations of ANP than others. These findings suggest the peptide could be key in identifying this specific heart abnormality in horses.
About the Study
- In this pilot study, the researchers explored the possible role of Atrial Natriuretic Peptide (ANP) as a biomarker in gauging the severity of heart disease in horses. ANP is a hormone that can help regulate blood pressure and body fluid volume.
- They formed three groups of horses: Group A (6 horses) had heart disease, but no abnormal heart chamber size and function; Group B (5 horses) had heart disease and displayed abnormalities such as left atrial enlargement, dysfunction, and/or left ventricular enlargement; Group C (13 horses) had no discernible heart disease.
- Plasma ANP concentrations (Cp(ANP)) were compared across all three groups.
Key Findings
- The median ANP concentration was significantly higher in Group B than in Group A and Group C. This indicates that the level of this peptide was much higher in horses whose heart disease was associated with enlargement of the left atrium.
- Through a backwards stepwise multiple linear regression analysis, it was found that in horses with heart disease, Cp(ANP) was associated with the dimensions of the left atrium, but there was no correlation with left ventricular size or function of either the left atrium or left ventricle.
Implications and Future Research
- The findings from this pilot study suggest that Cp(ANP) could potentially be used as a biomarker to detect enlargement of the left atrium in horses. This can greatly enhance the diagnostic process in equine veterinary cardiology.
- The correlation between Cp(ANP) and the severity of heart disease suggests that this biomarker could be instrumental in creating treatment plans and managing horse heart disease more effectively.
- However, due to the small sample size, the researchers recommend larger prospective studies to validate these early findings.
Cite This Article
APA
Trachsel DS, Grenacher B, Weishaupt MA, Schwarzwald CC.
(2011).
Plasma atrial natriuretic peptide concentrations in horses with heart disease: a pilot study.
Vet J, 192(2), 166-170.
https://doi.org/10.1016/j.tvjl.2011.06.035 Publication
Researcher Affiliations
- Equine Department, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland. dtrachsel@vetclinics.uzh.ch
MeSH Terms
- Animals
- Atrial Natriuretic Factor / blood
- Biomarkers / blood
- Female
- Heart Diseases / blood
- Heart Diseases / diagnostic imaging
- Heart Diseases / veterinary
- Horse Diseases / blood
- Horse Diseases / diagnostic imaging
- Horses
- Male
- Pilot Projects
- Ultrasonography
Citations
This article has been cited 3 times.- Berthoud D, Schwarzwald CC. Echocardiographic assessment of left ventricular size and systolic function in Warmblood horses using linear measurements, area-based indices, and volume estimates: A retrospective database analysis. J Vet Intern Med 2021 Jan;35(1):504-520.
- Pourmohammad R, Mohri M, Seifi HA, Sardari K. Evaluation of cardiac troponin I, atrial natriuretic peptide and some oxidative/antioxidative biomarkers in the serum and hemolysate of trained Arabian horses after exercise. Iran J Vet Res 2020 Summer;21(3):211-215.
- Huesler IM, Mitchell KJ, Schwarzwald CC. Echocardiographic Assessment of Left Atrial Size and Function in Warmblood Horses: Reference Intervals, Allometric Scaling, and Agreement of Different Echocardiographic Variables. J Vet Intern Med 2016 Jul;30(4):1241-52.
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