Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Plasma cortisol concentration increases within 6 hours of stabling in RAO-affected horses.
Abstract: In many inflammatory diseases plasma cortisol concentration (CORT) increases at the onset of acute inflammation, but the situation in recurrent airway obstruction (RAO) of horses is unknown. Methods: Split-plot repeated measures design with one grouping factor (disease) and two repeated factors (day and 3-hour intervals). Objective: To test the hypothesis that CORT increases as acute exacerbations of RAO develop. Methods: Four RAO-susceptible and 4 control horses were placed in a low dust environment (LDEnv) for 2 days followed by 2 days in a high dust environment (HDEnv). Exacerbations of RAO were indicated by increases in maximal change in pleural pressure (ΔPplmax) and decreases in breathing frequency variability (BFV), which was continuously measured by respiratory inductance plethysmography. Plasma samples for determination of CORT were collected every 6 h. Results: In control horses, ΔPplmax and BFV were unaffected by the HDEnv, whereas in RAO-affected horses ΔPplmax increased and BFV decreased significantly. In the LDEnv, there was a circadian variation in CORT in both control and RAO-affected horses. In HDEnv, CORT was unaffected in control horses, but increased significantly in RAO-affected horses between 6 and 12 h after entering the HDEnv. Conclusions: Plasma cortisol concentration increases concurrently with the development of acute exacerbations of RAO.
© 2013 EVJ Ltd.
Publication Date: 2013-12-19 PubMed ID: 24164413DOI: 10.1111/evj.12201Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
- Animal Health
- Animal Studies
- Clinical Study
- Cortisol
- Diagnosis
- Disease Diagnosis
- Disease Etiology
- Disease Treatment
- Equine Health
- Horses
- Immune Response
- In Vivo
- Inflammation
- Inflammatory Response
- Pathophysiology
- Plasma
- Recurrent Airway Obstruction
- Respiratory Disease
- Respiratory Health
- Stable Management
- Veterinary Medicine
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research examines the relationship between Cortisol, a hormone, and Recurrent Airway Obstruction (RAO) in horses. The findings reveal that Cortisol levels increase during acute exacerbations of RAO in horses, especially when exposed to a high dust environment.
Research Objectives and Method
- The study aimed to explore the hypothesis that plasma cortisol concentration (CORT) increases during acute exacerbations of Recurrent Airway Obstruction (RAO) in horses, a condition relatively comparable to asthma in humans.
- To investigate this, the researchers adopted a split-plot repeated measures design. This method involves measuring multiple variables over a series of moments in time, in this case, days and 3-hour intervals.
- The experiment involved eight horses, with four being susceptible to RAO (RAO-affected) and four serving as the control group.
- All horses were initially placed in a low dust environment (LDEnv) for two days and subsequently in a high dust environment (HDEnv) for another two days.
- The plasma samples from all horses were gathered every 6 hours to determine the levels of Cortisol.
Measures and Outcomes
- Some indicators of RAO exacerbation in horses are the increase in maximal change in pleural pressure (ΔPplmax) and decreases in breathing frequency variability (BFV).
- In the control group, both the ΔPplmax and BFV measures were unaffected by the HDEnv. However, in RAO-affected horses, the ΔPplmax significantly increased, and the BFV significantly decreased.
- A trace amount of circadian variation in Cortisol levels was observed in both control and RAO-affected horses while in the LDEnv.
- Upon introducing the horses to the HDEnv, Cortisol levels in the control group of horses were unaffected. Conversely, for RAO-affected horses, Cortisol levels significantly increased between 6 and 12 hours after their insertion into the HDEnv.
Conclusion
- The study concludes that elevated plasma cortisol concentration correlates with the developments of acute exacerbations of RAO among horses. Hence, the researchers’ original hypothesis is verified.
Cite This Article
APA
Shaba JJ, Behan Braman A, Robinson NE.
(2013).
Plasma cortisol concentration increases within 6 hours of stabling in RAO-affected horses.
Equine Vet J, 46(5), 642-644.
https://doi.org/10.1111/evj.12201 Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, USA.
MeSH Terms
- Animals
- Female
- Horse Diseases / blood
- Horse Diseases / metabolism
- Horses
- Housing, Animal
- Hydrocortisone / blood
- Lung Diseases, Obstructive / blood
- Lung Diseases, Obstructive / veterinary
- Male
Citations
This article has been cited 2 times.- Meiseberg LK, Delarocque J, de Buhr N, Ohnesorge B. Clinical variability of equine asthma phenotypes and analysis of diagnostic steps in phenotype differentiation. Acta Vet Scand 2024 Sep 18;66(1):51.
- Diez de Castro E, Fernandez-Molina JM. Environmental Management of Equine Asthma. Animals (Basel) 2024 Jan 30;14(3).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
