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Home / Equine Research Bank / J Vet Intern Med / Plasma Procalcitonin Concentration in Healthy Horses and Hor...
Journal of veterinary internal medicine2015; 29(6); 1689-1691; doi: 10.1111/jvim.13640

Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome.

Abstract: The diseases most frequent associated with SIRS in adult horses are those involving the gastrointestinal tract. An early diagnosis should be the goal in the management of horses with SIRS. Objective: The objective of this study was to evaluate the plasma procalcitonin (PCT) concentration in healthy and SIRS horses to assess differences between the two groups. Methods: Seventy-eight horses (30 healthy and 48 SIRS). Methods: Prospective in vivo multicentric study. Horses were classified as SIRS if at least 2 of the following criteria were met: abnormal leukocyte count or distribution, hyperthermia or hypothermia, tachycardia, tachypnea. Healthy horses showed no clinical or laboratory signs of SIRS. Plasma PCT concentrations were measured with a commercial ELISA assay for equine species. Results were expressed as mean±standard deviation. T-test for unpaired data was performed between healthy and SIRS group. SIRS group was divided in 4 subgroups and t-test was performed between healthy versus each subgroup. Results: PCT concentrations in healthy and SIRS horses were 18.28 ± 20.32 and 197.0 ± 117.0 pg/mL, respectively. T-test showed statistical differences between healthy versus SIRS group and between healthy versus all subgroups. Conclusions: Results showed an increase in PCT concentration in SIRS horses as previously reported in humans and dogs. PCT could be used as a single assay in equine practice for detection of SIRS.
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2015-10-16 PubMed ID: 26474412PubMed Central: PMC4895682DOI: 10.1111/jvim.13640Google Scholar: Lookup
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  • Journal Article
  • Multicenter Study
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research aimed to assess the plasma procalcitonin (PCT) concentration in healthy horses and those affected by systemic inflammatory response syndrome (SIRS), with the findings suggesting that elevated PCT levels could serve as a marker for SIRS in equine practice.

Research Objective

  • The main goal of the study was to measure and compare the PCT concentration in the plasma of healthy horses and horses affected by SIRS. This was to determine if any differences existed between the two groups that could provide insight into the relationship between PCT concentration and SIRS.

Methods

  • The researchers conducted a multicentric in vivo study involving 78 horses. The sample was divided into two groups: 30 healthy and 48 with SIRS.
  • Horses with at least 2 markers of SIRS (including abnormal leukocyte count or distribution, abnormal body temperature, tachycardia, tachypnea) were classified as part of the SIRS group.
  • The measurement of plasma PCT concentration was done using a commercial ELISA assay for equine species.

Results

  • The mean PCT concentration was noted to be 18.28 ± 20.32 pg/mL in healthy horses and 197.0 ± 117.0 pg/mL in SIRS horses.
  • The results of the t-test showed considerable statistical differences between the healthy and SIRS group, as well as between the healthy group and each of the SIRS subgroups.

Conclusions

  • Results from this study showed a significant increase in PCT concentration in horses affected by SIRS compared to healthy horses. This pattern aligns with findings in human and canine studies.
  • Given the observable difference, the researchers suggest PCT could be used as a single assay in equine practice for the detection of SIRS.

Cite This Article

APA
Bonelli F, Meucci V, Divers TJ, Jose-Cunilleras E, Corazza M, Tognetti R, Guidi G, Intorre L, Sgorbini M. (2015). Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome. J Vet Intern Med, 29(6), 1689-1691. https://doi.org/10.1111/jvim.13640

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 29
Issue: 6
Pages: 1689-1691

Researcher Affiliations

Bonelli, F
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.
Meucci, V
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.
Divers, T J
  • College of Veterinary Medicine, Cornell University, Ithaca, NY.
Jose-Cunilleras, E
  • Department of Animal Medicine and Surgery, Universitat Autonoma de Barcelona, Bellaterra, Spain.
Corazza, M
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.
Tognetti, R
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.
Guidi, G
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.
Intorre, L
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.
Sgorbini, M
  • Department of Veterinary Sciences, University of Pisa, San Piero a Grado, PI, Italy.

MeSH Terms

  • Animals
  • Calcitonin / blood
  • Calcitonin Gene-Related Peptide
  • Female
  • Horse Diseases / blood
  • Horses
  • Male
  • Protein Precursors / blood
  • Systemic Inflammatory Response Syndrome / blood

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Citations

This article has been cited 14 times.
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