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Journal of equine veterinary science2019; 86; 102820; doi: 10.1016/j.jevs.2019.102820

Platelet-Rich Products and Their Application to Osteoarthritis.

Abstract: Autologous platelet-rich plasma (PRP) is a biological preparation made from the patient's own plasma that contains a platelet concentration above the whole blood baseline. Owing to the release of growth factors and other cytokines after degranulation, platelets have a central role in inflammation and in different stages of the healing process. For this reason, PRP-derived products have been used to enhance healing of musculoskeletal injuries and modulate progression of inflammatory processes, including osteoarthritis (OA). Osteoarthritis is one of the main causes of musculoskeletal disabilities in horses, and currently, there is no effective treatment for this disease. Treatments that focus on the modulation of inflammation and disease progression offer new hope for OA. Platelet-rich plasma provides a more practical and accessible option of therapy compared to other forms of biological treatment (i.e., stem cell therapies) and is believed to induce the production of functional matrix. However, several factors related to PRP production, including methods of preparation and application, and intraindividual variability, lead to an inconsistent product, precluding reliable conclusions about its efficacy for clinical use. The aim of this study was to review the benefits related to the clinical use of PRP in OA as well as factors that influence its use, the limitations of this treatment, and future directions of PRP research and therapy.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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Publication Date: 2019-11-16 PubMed ID: 32067662DOI: 10.1016/j.jevs.2019.102820Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the use of autologous platelet-rich plasma (PRP), a concentrated solution of the patient’s own blood platelets, in treating osteoarthritis (OA) in horses, discussing various influential factors, limitations, and potential future directions for PRP therapy.

Role of Platelets and PRP

  • Platelets are blood cells that play a key role in bodily processes like inflammation and healing due to their release of growth factors and cytokines.
  • Platelet-rich plasma (PRP) is a product derived from the patient’s blood and contains a higher concentration of platelets than normal blood.
  • PRP products have been utilized to support the healing of musculoskeletal injuries and manage the progression of inflammatory conditions like osteoarthritis.

Osteoarthritis and Current Treatments

  • Osteoarthritis (OA) is a prevalent cause of musculoskeletal disabilities in horses and lacks an effective treatment.
  • Treatments targeting the regulation of inflammation and disease progression provide a fresh perspective for combating OA.

PRP Application in Osteoarthritis

  • PRP provides a more accessible and practical therapeutic option compared to other biological treatments like stem cell therapies.
  • PRP is thought to stimulate the production of the functional matrix, which contributes to the healing and regeneration of tissue.
  • There are inconsistencies in PRP production due to differences in methods of preparation and application, and individual variability.

Research Aim and Objectives

  • The study aimed to assess the clinical benefits of treating OA with PRP, identify factors influencing its usage, highlight the limitations of this treatment, and suggest future directions for PRP research and treatment.

Cite This Article

APA
Garbin LC, Olver CS. (2019). Platelet-Rich Products and Their Application to Osteoarthritis. J Equine Vet Sci, 86, 102820. https://doi.org/10.1016/j.jevs.2019.102820

Publication

Journal of equine veterinary science
ISSN: 0737-0806
NlmUniqueID: 8216840
Country: United States
Language: English
Volume: 86
Pages: 102820

Researcher Affiliations

Garbin, Livia Camargo
  • Department of Clinical Veterinary Sciences, School of Veterinary Medicine, Faculty of Medical Sciences, University of West Indies, St. Augustine, Trinidad and Tobago, West Indies. Electronic address: Livia.Garbin@sta.uwi.edu.
Olver, Christine S
  • Veterinary Diagnostic Laboratory, Clinical Pathology Section, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.

MeSH Terms

  • Animals
  • Blood Platelets
  • Horse Diseases
  • Horses
  • Inflammation / veterinary
  • Osteoarthritis / therapy
  • Osteoarthritis / veterinary
  • Platelet-Rich Plasma
  • Wound Healing

Citations

This article has been cited 37 times.
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