Portable mass spectrometry for measurement of anaesthetic agents and methane in respiratory gases.
Abstract: Monitoring the composition of gases breathed by anaesthetised patients requires measurement methods with fast responses, high accuracy and good reliability. There is also an increasing demand for systems to be able to monitor more than one target analyte simultaneously, but some gas analysers can be sensitive to the presence of methane gas in exhaled breath, consequently leading to inaccurate measurements of the anaesthetic agent. This study investigated the feasibility of employing portable quadrupole mass spectrometry to monitor volatile anaesthetic agents (halothane, isoflurane and sevoflurane), methane accumulation in anaesthetic rebreathing systems, and inspired and exhaled carbon dioxide and oxygen concentrations during equine anaesthesia in a clinical setting. The volatile anaesthetic agents were easily measurable and methane was detectable. The instrument had an advantage over short wavelength infrared absorption spectrometry analysers because it could monitor anaesthetic agents and other respiratory gases simultaneously and at extremely low concentrations, although further optimisation is required.
Publication Date: 2007-05-22 PubMed ID: 17521932DOI: 10.1016/j.tvjl.2007.03.017Google Scholar: Lookup
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- Journal Article
Summary
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The research paper explores the possibility of using portable quadrupole mass spectrometry for monitoring volatile anaesthetic agents, methane levels, and carbon dioxide and oxygen concentrations during equine anaesthesia. The preliminary results indicate that the instrument holds advantages over existing technologies, though further optimization is needed.
Objective of the Research
- This research aims to determine the effectiveness of a portable quadrupole mass spectrometry (a type of gas analysis tool) in tracking various respiratory gases during equine anaesthesia. Specifically, it focuses on volatile anaesthetic agents (halothane, isoflurane, and sevoflurane), the accumulation of methane in anaesthetic rebreathing systems, and the concentration of carbon dioxide and oxygen levels.
Context and Importance of the Study
- With an increasing need for fast, accurate, and reliable respiratory gas measurement tools in anaesthesia, the study’s findings are significant. More importantly, the tool should be capable of simultaneously monitoring different target analytes.
- The issue with several gas analysers is their sensitivity to methane gas in exhaled breath, leading to false measurements of anaesthetic agents. The development of an effective tool that can overcome this issue is what motivated this study.
Findings and Observations
- Results showed that it was feasible to use portable quadrupole mass spectrometry to measure volatile anaesthetic agents and detect methane accumulation.
- The tool demonstrated an advantage over existing short-wavelength infrared absorption spectrometry analysers, given its ability to monitor various respiratory gases at the same time and at substantially low concentrations.
Conclusion and Future Work
- While the results of the research are promising, suggesting that the portable quadrupole mass spectrometry could be a suitable tool for monitoring anesthetic agents in a clinical setting, there is still a need for further optimization before it becomes a standard tool in anaesthetic procedures.
Cite This Article
APA
Turner PG, Dugdale A, Young IS, Taylor S.
(2007).
Portable mass spectrometry for measurement of anaesthetic agents and methane in respiratory gases.
Vet J, 177(1), 36-44.
https://doi.org/10.1016/j.tvjl.2007.03.017 Publication
Researcher Affiliations
- Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, UK.
MeSH Terms
- Anesthesia, General / veterinary
- Animals
- Breath Tests
- Female
- Halothane / pharmacokinetics
- Horses / physiology
- Isoflurane / pharmacokinetics
- Male
- Mass Spectrometry / instrumentation
- Mass Spectrometry / methods
- Mass Spectrometry / veterinary
- Methane / analysis
- Methyl Ethers / pharmacokinetics
- Monitoring, Intraoperative / instrumentation
- Monitoring, Intraoperative / methods
- Monitoring, Intraoperative / veterinary
- Reproducibility of Results
- Sensitivity and Specificity
- Sevoflurane
Grant Funding
- G0401462 / Medical Research Council
Citations
This article has been cited 2 times.- Wang J, Pursell ME, DeVor A, Awoyemi O, Valentine SJ, Li P. Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis. Proteomics 2022 Dec;22(23-24):e2200112.
- Hoffmann WD, Jin F, Pedder RE, Taormina C, Jackson GP. Performance evaluation of a Loeb-Eiber mass filter at 1 Torr. J Am Soc Mass Spectrom 2015 Feb;26(2):286-91.
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