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Home / Equine Research Bank / Immunogenetics / Positive selection in the SLC11A1 gene in the family Equidae...
Immunogenetics2016; 68(5); 353-364; doi: 10.1007/s00251-016-0905-2

Positive selection in the SLC11A1 gene in the family Equidae.

Abstract: Immunity-related genes are a suitable model for studying effects of selection at the genomic level. Some of them are highly conserved due to functional constraints and purifying selection, while others are variable and change quickly to cope with the variation of pathogens. The SLC11A1 gene encodes a transporter protein mediating antimicrobial activity of macrophages. Little is known about the patterns of selection shaping this gene during evolution. Although it is a typical evolutionarily conserved gene, functionally important polymorphisms associated with various diseases were identified in humans and other species. We analyzed the genomic organization, genetic variation, and evolution of the SLC11A1 gene in the family Equidae to identify patterns of selection within this important gene. Nucleotide SLC11A1 sequences were shown to be highly conserved in ten equid species, with more than 97 % sequence identity across the family. Single nucleotide polymorphisms (SNPs) were found in the coding and noncoding regions of the gene. Seven codon sites were identified to be under strong purifying selection. Codons located in three regions, including the glycosylated extracellular loop, were shown to be under diversifying selection. A 3-bp indel resulting in a deletion of the amino acid 321 in the predicted protein was observed in all horses, while it has been maintained in all other equid species. This codon comprised in an N-glycosylation site was found to be under positive selection. Interspecific variation in the presence of predicted N-glycosylation sites was observed.
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Publication Date: 2016-02-04 PubMed ID: 26846480DOI: 10.1007/s00251-016-0905-2Google Scholar: Lookup
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The researchers studied the gene SLC11A1 in the family Equidae, which includes horses and related species. Their findings suggest the gene, which is important for immune response, has been under strong evolutionary influence to both preserve and diversify aspects of its makeup.

Background and Purpose of Study

  • The study focuses on the SLC11A1 gene that encodes for a transporter protein that has antimicrobial activities in macrophages, a type of immune cell.
  • This gene has been identified in humans and other species, having numerous polymorphisms tied to various diseases, but relatively little is known about its evolution over time or how natural selection has shaped it.
  • The researchers aimed to analyze the genomic organization, genetic variation, and evolution of this gene in the family Equidae (which includes horses and related species), looking for specific patterns of selection within the gene that may provide insights into its role in immunity.

Research Methods and Findings

  • By analyzing nucleotide sequences of the SLC11A1 gene across ten different species within the family Equidae, the research team found that the gene is highly conserved, having more than 97% identical sequence across all species studied.
  • However, they also identified several single nucleotide polymorphisms (SNPs) in both the coding and noncoding regions of the gene, suggesting some variation.
  • They identified seven codon sites in the gene that are under strong purifying selection – meaning they remain relatively unchanged over time due to the selective pressure to preserve their function.
  • Yet, they also discovered codons (the specific DNA sequence that codes for a protein) in three different regions of the gene that appear to be under diversifying selection, suggesting they have changed over time to adapt to different threats.
  • One such change that occurred uniformly in all horses studied was a deletion of the amino acid 321 in the predicted protein, while this amino acid was maintained in all other species in the family Equidae.
  • This particular codon, part of a site for N-glycosylation (the process where sugars attach to proteins), was under positive selection, suggesting some evolutionary benefit to the change.
  • The research team also noticed interspecific variation in the presence of predicted N-glycosylation sites, meaning these sites differed between species.

Conclusions

  • The findings provide insights into the evolution of the SLC11A1 gene within the Equidae family hinting at its importance in their immune response system and the adaptability required to cope up with varying pathogens.
  • This combination of strong purifying selection and diversifying selection indicates that while the gene’s core function is conserved to a large degree, certain aspects of its structure and function have evolved in response to environmental pressures, possibly including interactions with pathogens. This highlights both the stability and adaptability innate to immune systems.

Cite This Article

APA
Bayerova Z, Janova E, Matiasovic J, Orlando L, Horin P. (2016). Positive selection in the SLC11A1 gene in the family Equidae. Immunogenetics, 68(5), 353-364. https://doi.org/10.1007/s00251-016-0905-2

Publication

Immunogenetics
ISSN: 1432-1211
NlmUniqueID: 0420404
Country: United States
Language: English
Volume: 68
Issue: 5
Pages: 353-364

Researcher Affiliations

Bayerova, Zuzana
  • Department of Animal Genetics, Research Group Immunogenomics, Ceitec VFU, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Janova, Eva
  • Department of Animal Genetics, Research Group Immunogenomics, Ceitec VFU, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Matiasovic, Jan
  • Department of Immunology, Veterinary Research Institute, Brno, Czech Republic.
Orlando, Ludovic
  • Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
Horin, Petr
  • Department of Animal Genetics, Research Group Immunogenomics, Ceitec VFU, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. horin@dior.ics.muni.cz.

MeSH Terms

  • Animals
  • Cation Transport Proteins / genetics
  • Codon / genetics
  • Equidae / genetics
  • Evolution, Molecular
  • Genomics
  • Phylogeny
  • Polymorphism, Single Nucleotide / genetics
  • Selection, Genetic / genetics

References

This article includes 56 references
  1. Kim DS, Hahn Y. The acquisition of novel N-glycosylation sites in conserved proteins during human evolution.. BMC Bioinformatics 2015 Jan 28;16(1):29.
    pubmed: 25628020doi: 10.1186/s12859-015-0468-5google scholar: lookup
  2. Barnes I, Duda A, Pybus OG, Thomas MG. Ancient urbanization predicts genetic resistance to tuberculosis.. Evolution 2011 Mar;65(3):842-8.
    pubmed: 20840594doi: 10.1111/j.1558-5646.2010.01132.xgoogle scholar: lookup
  3. Chapman SJ, Hill AV. Human genetic susceptibility to infectious disease.. Nat Rev Genet 2012 Feb 7;13(3):175-88.
    pubmed: 22310894doi: 10.1038/nrg3114google scholar: lookup
  4. Trifonov VA, Musilova P, Kulemsina AI. Chromosome evolution in Perissodactyla.. Cytogenet Genome Res 2012;137(2-4):208-17.
    pubmed: 22813844doi: 10.1159/000339900google scholar: lookup
  5. Bradley DJ. Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.. Clin Exp Immunol 1977 Oct;30(1):130-40.
    pubmed: 606434
  6. Salinas-Delgado Y, Galaviz-Hernández C, Toral RG, Ávila Rejón CA, Reyes-Lopez MA, Martínez AR, Martínez-Aguilar G, Sosa-Macías M. The D543N polymorphism of the SLC11A1/NRAMP1 gene is associated with treatment failure in male patients with pulmonary tuberculosis.. Drug Metab Pers Ther 2015 Sep;30(3):211-4.
    pubmed: 26353180doi: 10.1515/dmpt-2015-0019google scholar: lookup
  7. Segond D, Dellagi A, Lanquar V, Rigault M, Patrit O, Thomine S, Expert D. NRAMP genes function in Arabidopsis thaliana resistance to Erwinia chrysanthemi infection.. Plant J 2009 Apr;58(2):195-207.
    pubmed: 19121106doi: 10.1111/j.1365-313X.2008.03775.xgoogle scholar: lookup
  8. Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, Malaspinas AS, Vogt J, Szklarczyk D, Kelstrup CD, Vinther J, Dolocan A, Stenderup J, Velazquez AM, Cahill J, Rasmussen M, Wang X, Min J, Zazula GD, Seguin-Orlando A, Mortensen C, Magnussen K, Thompson JF, Weinstock J, Gregersen K, Røed KH, Eisenmann V, Rubin CJ, Miller DC, Antczak DF, Bertelsen MF, Brunak S, Al-Rasheid KA, Ryder O, Andersson L, Mundy J, Krogh A, Gilbert MT, Kjær K, Sicheritz-Ponten T, Jensen LJ, Olsen JV, Hofreiter M, Nielsen R, Shapiro B, Wang J, Willerslev E. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse.. Nature 2013 Jul 4;499(7456):74-8.
    pubmed: 23803765doi: 10.1038/nature12323google scholar: lookup
  9. Forbes JR, Gros P. Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions.. Trends Microbiol 2001 Aug;9(8):397-403.
    pubmed: 11514223doi: 10.1016/s0966-842x(01)02098-4google scholar: lookup
  10. Vilstrup JT, Seguin-Orlando A, Stiller M, Ginolhac A, Raghavan M, Nielsen SC, Weinstock J, Froese D, Vasiliev SK, Ovodov ND, Clary J, Helgen KM, Fleischer RC, Cooper A, Shapiro B, Orlando L. Mitochondrial phylogenomics of modern and ancient equids.. PLoS One 2013;8(2):e55950.
    pubmed: 23437078doi: 10.1371/journal.pone.0055950google scholar: lookup
  11. Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: families SLC11 and SLC40.. Mol Aspects Med 2013 Apr-Jun;34(2-3):270-87.
    pubmed: 23506870doi: 10.1016/j.mam.2013.01.002google scholar: lookup
  12. Pond SL, Frost SD. Datamonkey: rapid detection of selective pressure on individual sites of codon alignments.. Bioinformatics 2005 May 15;21(10):2531-3.
    pubmed: 15713735doi: 10.1093/bioinformatics/bti320google scholar: lookup
  13. Kosakovsky Pond SL, Posada D, Gravenor MB, Woelk CH, Frost SD. GARD: a genetic algorithm for recombination detection.. Bioinformatics 2006 Dec 15;22(24):3096-8.
    pubmed: 17110367doi: 10.1093/bioinformatics/btl474google scholar: lookup
  14. Purdie AC, Plain KM, Begg DJ, de Silva K, Whittington RJ. Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: a review.. Comp Immunol Microbiol Infect Dis 2011 May;34(3):197-208.
    pubmed: 21216466doi: 10.1016/j.cimid.2010.12.003google scholar: lookup
  15. Techau ME, Valdez-Taubas J, Popoff JF, Francis R, Seaman M, Blackwell JM. Evolution of differences in transport function in Slc11a family members.. J Biol Chem 2007 Dec 7;282(49):35646-56.
    pubmed: 17932044doi: 10.1074/jbc.M707057200google scholar: lookup
  16. Pinheiro A, Woof JM, Almeida T, Abrantes J, Alves PC, Gortázar C, Esteves PJ. Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains.. Open Biol 2014 Sep;4(9):140088.
    pubmed: 25185680doi: 10.1098/rsob.140088google scholar: lookup
  17. Feng DF, Johnson MS, Doolittle RF. Aligning amino acid sequences: comparison of commonly used methods.. J Mol Evol 1984-1985;21(2):112-25.
    pubmed: 6100188doi: 10.1007/BF02100085google scholar: lookup
  18. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.. Mol Biol Evol 2013 Dec;30(12):2725-9.
    pubmed: 24132122doi: 10.1093/molbev/mst197google scholar: lookup
  19. Vidal S, Tremblay ML, Govoni G, Gauthier S, Sebastiani G, Malo D, Skamene E, Olivier M, Jothy S, Gros P. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.. J Exp Med 1995 Sep 1;182(3):655-66.
    pubmed: 7650477doi: 10.1084/jem.182.3.655google scholar: lookup
  20. Blackwell JM, Goswami T, Evans CA, Sibthorpe D, Papo N, White JK, Searle S, Miller EN, Peacock CS, Mohammed H, Ibrahim M. SLC11A1 (formerly NRAMP1) and disease resistance.. Cell Microbiol 2001 Dec;3(12):773-84.
    pubmed: 11736990doi: 10.1046/j.1462-5822.2001.00150.xgoogle scholar: lookup
  21. Searle S, Blackwell JM. Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility.. J Med Genet 1999 Apr;36(4):295-9.
    pubmed: 10227396
  22. Pond SL, Frost SD. A genetic algorithm approach to detecting lineage-specific variation in selection pressure.. Mol Biol Evol 2005 Mar;22(3):478-85.
    pubmed: 15509724doi: 10.1093/molbev/msi031google scholar: lookup
  23. Blackwell JM, Searle S, Goswami T, Miller EN. Understanding the multiple functions of Nramp1.. Microbes Infect 2000 Mar;2(3):317-21.
    pubmed: 10758409doi: 10.1016/s1286-4579(00)00295-1google scholar: lookup
  24. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. A method and server for predicting damaging missense mutations.. Nat Methods 2010 Apr;7(4):248-9.
    pubmed: 20354512doi: 10.1038/nmeth0410-248google scholar: lookup
  25. Karlsson EK, Kwiatkowski DP, Sabeti PC. Natural selection and infectious disease in human populations.. Nat Rev Genet 2014 Jun;15(6):379-93.
    pubmed: 24776769doi: 10.1038/nrg3734google scholar: lookup
  26. Li X, Yang Y, Zhou F, Zhang Y, Lu H, Jin Q, Gao L. SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis.. PLoS One 2011 Jan 25;6(1):e15831.
    pubmed: 21283567doi: 10.1371/journal.pone.0015831google scholar: lookup
  27. Huang J, Zhao Y, Shiraigol W, Li B, Bai D, Ye W, Daidiikhuu D, Yang L, Jin B, Zhao Q, Gao Y, Wu J, Bao W, Li A, Zhang Y, Han H, Bai H, Bao Y, Zhao L, Zhai Z, Zhao W, Sun Z, Zhang Y, Meng H, Dugarjaviin M. Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype.. Sci Rep 2014 May 14;4:4958.
    pubmed: 24828444doi: 10.1038/srep04958google scholar: lookup
  28. Wlasiuk G, Nachman MW. Adaptation and constraint at Toll-like receptors in primates.. Mol Biol Evol 2010 Sep;27(9):2172-86.
    pubmed: 20410160doi: 10.1093/molbev/msq104google scholar: lookup
  29. Takahashi K, Hasegawa Y, Abe T, Yamamoto T, Nakashima K, Imaizumi K, Shimokata K. SLC11A1 (formerly NRAMP1) polymorphisms associated with multidrug-resistant tuberculosis.. Tuberculosis (Edinb) 2008 Jan;88(1):52-7.
    pubmed: 17950034doi: 10.1016/j.tube.2007.08.008google scholar: lookup
  30. Johnson EE, Wessling-Resnick M. Iron metabolism and the innate immune response to infection.. Microbes Infect 2012 Mar;14(3):207-16.
    pubmed: 22033148doi: 10.1016/j.micinf.2011.10.001google scholar: lookup
  31. Blackwell JM. The macrophage resistance gene Lsh/Ity/Bcg.. Res Immunol 1989 Oct;140(8):767-9.
    pubmed: 2696047
  32. Williams R, Ma X, Schott RK, Mohammad N, Ho CY, Li CF, Chang BS, Demetriou M, Dennis JW. Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution.. PLoS One 2014;9(1):e86088.
    pubmed: 24475074doi: 10.1371/journal.pone.0086088google scholar: lookup
  33. Blackwell JM, Roberts CW, Roach TI, Alexander J. Influence of macrophage resistance gene Lsh/Ity/Bcg (candidate Nramp) on Toxoplasma gondii infection in mice.. Clin Exp Immunol 1994 Jul;97(1):107-12.
    pubmed: 8033407doi: 10.1111/j.1365-2249.1994.tb06587.xgoogle scholar: lookup
  34. Gruenheid S, Gros P. Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport.. Curr Opin Microbiol 2000 Feb;3(1):43-8.
    pubmed: 10679418doi: 10.1016/s1369-5274(99)00049-1google scholar: lookup
  35. Kosakovsky Pond SL, Murrell B, Fourment M, Frost SD, Delport W, Scheffler K. A random effects branch-site model for detecting episodic diversifying selection.. Mol Biol Evol 2011 Nov;28(11):3033-43.
    pubmed: 21670087doi: 10.1093/molbev/msr125google scholar: lookup
  36. Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite.. Blood 2007 Oct 15;110(8):3039-48.
    pubmed: 17606764doi: 10.1182/blood-2006-12-063289google scholar: lookup
  37. Jónsson H, Schubert M, Seguin-Orlando A, Ginolhac A, Petersen L, Fumagalli M, Albrechtsen A, Petersen B, Korneliussen TS, Vilstrup JT, Lear T, Myka JL, Lundquist J, Miller DC, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, Stagegaard J, Strauss G, Bertelsen MF, Sicheritz-Ponten T, Antczak DF, Bailey E, Nielsen R, Willerslev E, Orlando L. Speciation with gene flow in equids despite extensive chromosomal plasticity.. Proc Natl Acad Sci U S A 2014 Dec 30;111(52):18655-60.
    pubmed: 25453089doi: 10.1073/pnas.1412627111google scholar: lookup
  38. Stienstra Y, van der Werf TS, Oosterom E, Nolte IM, van der Graaf WT, Etuaful S, Raghunathan PL, Whitney EA, Ampadu EO, Asamoa K, Klutse EY, te Meerman GJ, Tappero JW, Ashford DA, van der Steege G. Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism.. Genes Immun 2006 Apr;7(3):185-9.
    pubmed: 16395392doi: 10.1038/sj.gene.6364281google scholar: lookup
  39. Nergadze SG, Lupotto M, Pellanda P, Santagostino M, Vitelli V, Giulotto E. Mitochondrial DNA insertions in the nuclear horse genome.. Anim Genet 2010 Dec;41 Suppl 2:176-85.
    pubmed: 21070293doi: 10.1111/j.1365-2052.2010.02130.xgoogle scholar: lookup
  40. Goswami T, Bhattacharjee A, Babal P, Searle S, Moore E, Li M, Blackwell JM. Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter.. Biochem J 2001 Mar 15;354(Pt 3):511-9.
    pubmed: 11237855doi: 10.1042/0264-6021:3540511google scholar: lookup
  41. Matiasovic J, Kubícková S, Musilová P, Rubes J, Horín P. Characterization of the NRAMP1 (SLC11A1) gene in the horse (Equus caballus L.).. Eur J Immunogenet 2002 Oct;29(5):423-9.
    pubmed: 12358853doi: 10.1046/j.1365-2370.2002.00348.xgoogle scholar: lookup
  42. Dinkel H, Van Roey K, Michael S, Davey NE, Weatheritt RJ, Born D, Speck T, Krüger D, Grebnev G, Kuban M, Strumillo M, Uyar B, Budd A, Altenberg B, Seiler M, Chemes LB, Glavina J, Sánchez IE, Diella F, Gibson TJ. The eukaryotic linear motif resource ELM: 10 years and counting.. Nucleic Acids Res 2014 Jan;42(Database issue):D259-66.
    pubmed: 24214962doi: 10.1093/nar/gkt1047google scholar: lookup
  43. Cellier MF. Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes.. Biology (Basel) 2013 Jan 25;2(1):233-83.
    pubmed: 24832660doi: 10.3390/biology2010233google scholar: lookup
  44. Qanbari S, Strom TM, Haberer G, Weigend S, Gheyas AA, Turner F, Burt DW, Preisinger R, Gianola D, Simianer H. A high resolution genome-wide scan for significant selective sweeps: an application to pooled sequence data in laying chickens.. PLoS One 2012;7(11):e49525.
    pubmed: 23209582doi: 10.1371/journal.pone.0049525google scholar: lookup
  45. Neves JV, Wilson JM, Kuhl H, Reinhardt R, Castro LF, Rodrigues PN. Natural history of SLC11 genes in vertebrates: tales from the fish world.. BMC Evol Biol 2011 Apr 18;11:106.
    pubmed: 21501491doi: 10.1186/1471-2148-11-106google scholar: lookup
  46. Schubert M, Jónsson H, Chang D, Der Sarkissian C, Ermini L, Ginolhac A, Albrechtsen A, Dupanloup I, Foucal A, Petersen B, Fumagalli M, Raghavan M, Seguin-Orlando A, Korneliussen TS, Velazquez AM, Stenderup J, Hoover CA, Rubin CJ, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, MacHugh DE, Kalbfleisch T, MacLeod JN, Rubin EM, Sicheritz-Ponten T, Andersson L, Hofreiter M, Marques-Bonet T, Gilbert MT, Nielsen R, Excoffier L, Willerslev E, Shapiro B, Orlando L. Prehistoric genomes reveal the genetic foundation and cost of horse domestication.. Proc Natl Acad Sci U S A 2014 Dec 30;111(52):E5661-9.
    pubmed: 25512547doi: 10.1073/pnas.1416991111google scholar: lookup
  47. Ortutay C, Vihinen M. Conserved and quickly evolving immunome genes have different evolutionary paths.. Hum Mutat 2012 Oct;33(10):1456-63.
    pubmed: 22623381doi: 10.1002/humu.22125google scholar: lookup
  48. Skamene E, Gros P, Forget A, Kongshavn PA, St Charles C, Taylor BA. Genetic regulation of resistance to intracellular pathogens.. Nature 1982 Jun 10;297(5866):506-9.
    pubmed: 7045675doi: 10.1038/297506a0google scholar: lookup
  49. Lemos de Matos A, McFadden G, Esteves PJ. Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus.. Immunogenetics 2014 Jan;66(1):43-52.
    pubmed: 24220721doi: 10.1007/s00251-013-0740-7google scholar: lookup
  50. McLaren W, Pritchard B, Rios D, Chen Y, Flicek P, Cunningham F. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor.. Bioinformatics 2010 Aug 15;26(16):2069-70.
    pubmed: 20562413doi: 10.1093/bioinformatics/btq330google scholar: lookup
  51. Barton CH, Biggs TE, Baker ST, Bowen H, Atkinson PG. Nramp1: a link between intracellular iron transport and innate resistance to intracellular pathogens.. J Leukoc Biol 1999 Nov;66(5):757-62.
    pubmed: 10577506doi: 10.1002/jlb.66.5.757google scholar: lookup
  52. Taype CA, Castro JC, Accinelli RA, Herrera-Velit P, Shaw MA, Espinoza JR. Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population.. Infect Genet Evol 2006 Sep;6(5):361-7.
    pubmed: 16461017doi: 10.1016/j.meegid.2006.01.002google scholar: lookup
  53. Plant J, Glynn AA. Genetics of resistance to infection with Salmonella typhimurium in mice.. J Infect Dis 1976 Jan;133(1):72-8.
    pubmed: 1107437doi: 10.1093/infdis/133.1.72google scholar: lookup
  54. Forbes JR, Gros P. Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane.. Blood 2003 Sep 1;102(5):1884-92.
    pubmed: 12750164doi: 10.1182/blood-2003-02-0425google scholar: lookup
  55. Risler JL, Delorme MO, Delacroix H, Henaut A. Amino acid substitutions in structurally related proteins. A pattern recognition approach. Determination of a new and efficient scoring matrix.. J Mol Biol 1988 Dec 20;204(4):1019-29.
    pubmed: 3221397doi: 10.1016/0022-2836(88)90058-7google scholar: lookup
  56. Ates O, Kurt S, Bozkurt N, Karaer H. NRAMP1 (SLC11A1) variants: genetic susceptibility to multiple Sclerosis.. J Clin Immunol 2010 Jul;30(4):583-6.
    pubmed: 20405176doi: 10.1007/s10875-010-9422-5google scholar: lookup

Citations

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    doi: 10.1007/s11033-019-04900-wpubmed: 31175514google scholar: lookup
  2. Ruiz-Larrañaga O, Langa J, Rendo F, Manzano C, Iriondo M, Estonba A. Genomic selection signatures in sheep from the Western Pyrenees. Genet Sel Evol 2018 Mar 22;50(1):9.
    doi: 10.1186/s12711-018-0378-xpubmed: 29566643google scholar: lookup
  3. Stejskalova K, Vychodilova L, Janova E, Oppelt J, Horin P. Innate Immunity Toll-Like Triad TLR6-1-10 and Its Diversity in Distinct Horse Breeds. Vet Med Sci 2025 Mar;11(2):e70230.
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  4. Stejskalova K, Janova E, Splichalova P, Futas J, Oppelt J, Vodicka R, Horin P. Twelve toll-like receptor (TLR) genes in the family Equidae - comparative genomics, selection and evolution. Vet Res Commun 2024 Apr;48(2):725-741.
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