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Frontiers in veterinary science2024; 10; 1201017; doi: 10.3389/fvets.2023.1201017

Post-mortem feasibility of dual-energy computed tomography in the detection of bone edema-like lesions in the equine foot: a proof of concept.

Abstract: In this proof-of-concept study, the post-mortem feasibility of dual-energy computed tomography (DECT) in the detection of bone edema-like lesions in the equine foot is described in agreement with the gold standard imaging technique, which is magnetic resonance imaging (MRI). Unassigned: A total of five equine cadaver feet were studied, of which two were pathological and three were within normal limits and served as references. A low-field MRI of each foot was performed, followed by a DECT acquisition. Multiplanar reformations of DECT virtual non-calcium images were compared with MRI for the detection of bone edema-like lesions. A gross post-mortem was performed, and histopathologic samples were obtained of the navicular and/or distal phalanx of the two feet selected based on pathology and one reference foot. Unassigned: On DECT virtual non-calcium imaging, the two pathological feet showed diffuse increased attenuation corresponding with bone edema-like lesions, whereas the three reference feet were considered normal. These findings were in agreement with the findings on the MRI. Histopathology of the two pathologic feet showed abnormalities in line with bone edema-like lesions. Histopathology of the reference foot was normal. Unassigned: DECT virtual non-calcium imaging can be a valuable diagnostic tool in the diagnosis of bone edema-like lesions in the equine foot. Further examination of DECT in equine diagnostic imaging is warranted in a larger cohort, different locations, and alive animals.
Copyright © 2024 Germonpré, Vandekerckhove, Raes, Chiers, Jans and Vanderperren.
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Publication Date: 2024-01-04 PubMed ID: 38249561PubMed Central: PMC10797750DOI: 10.3389/fvets.2023.1201017Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article describes an initial study on the viability of using dual-energy computed tomography (DECT) to detect bone edema-like lesions in horse feet, validating its results against the current best imaging methodology, magnetic resonance imaging (MRI).

Research Methodology

  • The researchers chose five horse cadaver feet for their study, two of which exhibited pathology and three of which were normal and therefore served reference purposes.
  • Each foot was initially examined using a low-field magnetic resonance imaging (MRI), followed by DECT acquisition.
  • The research team created multiplanar reformations of the DECT virtual non-calcium images and compared these with the MRI results to detect bone edema-like lesions.
  • A physical autopsy was carried out, and histopathologic samples were gathered from the navicular and/or distal phalanx of the two pathological feet and one reference foot.

Findings

  • The virtual non-calcium DECT images for the two pathological feet displayed diffuse increased attenuation, indicative of bone edema-like lesions, while the three reference feet were considered normal.
  • The DECT findings matched those derived from the MRI, giving credence to the utility of the DECT method.
  • The post-mortem assessment of the two pathological feet demonstrated abnormalities consistent with bone edema-like lesions, whereas the reference foot was normal.

Conclusions and Further Research

  • Based on these results, the authors conclude that DECT virtual non-calcium imaging has potential as a significant diagnostic tool in the detection of bone edema-like lesions in the foot of the horse.
  • The authors recommend additional research involving a larger sample size, varying locations, and living subjects to further validate and expand on their proof-of-concept findings.

Cite This Article

APA
Germonpré J, Vandekerckhove LMJ, Raes E, Chiers K, Jans L, Vanderperren K. (2024). Post-mortem feasibility of dual-energy computed tomography in the detection of bone edema-like lesions in the equine foot: a proof of concept. Front Vet Sci, 10, 1201017. https://doi.org/10.3389/fvets.2023.1201017

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 10
Pages: 1201017
PII: 1201017

Researcher Affiliations

Germonpré, Jolien
  • Department of Morphology, Imaging, Orthopedics, Rehabilitation, and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Vandekerckhove, Louis M J
  • Department of Morphology, Imaging, Orthopedics, Rehabilitation, and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Raes, Els
  • Department of Morphology, Imaging, Orthopedics, Rehabilitation, and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Chiers, Koen
  • Department of Pathobiology, Pharmacology, and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Jans, Lennart
  • Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium.
Vanderperren, Katrien
  • Department of Morphology, Imaging, Orthopedics, Rehabilitation, and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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