Potential applications of equine genomics in dissecting diseases and fertility.
Abstract: Following the recent development of high-resolution gene maps and generation of several basic tools and resources to use them in analyzing traits that are economically important to horse owners, genome analysis in horses is witnessing a shift towards developing an ability to analyze complex traits. The likelihood of this happening in the very near future is great, mainly because of the recent availability of the whole genome sequence in the horse. The latter has triggered the development of novel tools like SNP-chip and expression arrays that will permit rapid genome-wide analysis. While these tools will be used for a range of multi-factorial disease traits, attempts are underway to develop focused tools that can target reproduction, fertility and sex determination. For this, a catalog of sex and reproduction related (SRR) genes is being developed in horses. A recently developed dense map of the horse Y chromosome will provide genes that are expressed exclusively in males and, therefore, have an impact on stallion fertility. Overall, these advances in equine genome analysis hold promise for improved diagnosis and treatment of various conditions in horses.
Publication Date: 2008-04-29 PubMed ID: 18524508DOI: 10.1016/j.anireprosci.2008.04.010Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article discusses the recent advances in equine genomics and how these could be used to understand and address health and fertility issues in horses better.
Progress in Equine Genomics
- The research focuses on the promising advances in genomics, particularly in horses, following the development of high-resolution gene maps. These developments mark a shift towards analyzing complex traits, an aspect likely to revolutionize the genomics and biology field.
- These advancements have been made possible due to the recent availability of the whole genome sequence in the horse. This pivotal milestone has sparked an array of innovative tools such as SNP-chip and expression arrays, enabling rapid genome-wide analysis.
Focus on Multi-factorial Disease Traits
- In light of the new genomics techniques and tools, this research also highlights the potential of these developments to address a broad range of multi-factorial disease traits. These may include genetic diseases or conditions that are influenced by multiple genetic and environmental factors.
Targeting Reproduction, Fertility, and Sex Determination
- The researchers recognize the potential of these genomics advancements to develop specialized tools that can target reproduction, fertility, and sex determination.
- To facilitate this, a catalog of sex and reproduction-related (SRR) genes is being developed in horses. This catalog will serve as a valuable resource in horse breeding strategies and fertility studies.
Role of the Dense Map of the Horse Y Chromosome
- The study reveals the development of a dense map of the horse Y chromosome, which will provide genes expressed exclusively in males. This will help understand the genetic factors impacting stallion fertility and could lead to improved strategies for stallion breeding.
Potential Improvements in Equine Health
- Overall, researchers are optimistic that these advancements in equine genome analysis may lead to improved diagnosis and treatment of various conditions in horses. This includes not only conditions related to reproduction and fertility but also those related to other multi-factorial diseases.
Cite This Article
APA
Chowdhary BP, Paria N, Raudsepp T.
(2008).
Potential applications of equine genomics in dissecting diseases and fertility.
Anim Reprod Sci, 107(3-4), 208-218.
https://doi.org/10.1016/j.anireprosci.2008.04.010 Publication
Researcher Affiliations
- Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4458, USA. bchowdhary@cvm.tamu.edu
MeSH Terms
- Animals
- Fertility / genetics
- Genome
- Genomics / methods
- Genomics / trends
- Horse Diseases / genetics
- Horses / genetics
- Male
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- Reproduction / genetics
Citations
This article has been cited 10 times.- Cardinali I, Giontella A, Tommasi A, Silvestrelli M, Lancioni H. Unlocking Horse Y Chromosome Diversity.. Genes (Basel) 2022 Dec 2;13(12).
- Rossetti C, Genualdo V, Incarnato D, Mottola F, Perucatti A, Pauciullo A. State of the art on the physical mapping of the Y-chromosome in the Bovidae and comparison with other species - A review.. Anim Biosci 2022 Sep;35(9):1289-1302.
- Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.. Anim Genet 2019 Dec;50(6):569-597.
- Kikuchi K, Sasaki K, Akizawa H, Tsukahara H, Bai H, Takahashi M, Nambo Y, Hata H, Kawahara M. Identification and expression analysis of cDNA encoding insulin-like growth factor 2 in horses.. J Reprod Dev 2018 Feb 27;64(1):57-64.
- Kim MC, Lee SW, Ryu DY, Cui FJ, Bhak J, Kim Y. Identification and characterization of microRNAs in normal equine tissues by Next Generation Sequencing.. PLoS One 2014;9(4):e93662.
- Balasuriya UB, Go YY, MacLachlan NJ. Equine arteritis virus.. Vet Microbiol 2013 Nov 29;167(1-2):93-122.
- Paria N, Raudsepp T, Pearks Wilkerson AJ, O'Brien PC, Ferguson-Smith MA, Love CC, Arnold C, Rakestraw P, Murphy WJ, Chowdhary BP. A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals.. PLoS One 2011;6(7):e21374.
- Brosnahan MM, Brooks SA, Antczak DF. Equine clinical genomics: A clinician's primer.. Equine Vet J 2010 Oct;42(7):658-70.
- Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC, Lander ES, Lindblad-Toh K. Genome sequence, comparative analysis, and population genetics of the domestic horse.. Science 2009 Nov 6;326(5954):865-7.
- Bright LA, Burgess SC, Chowdhary B, Swiderski CE, McCarthy FM. Structural and functional-annotation of an equine whole genome oligoarray.. BMC Bioinformatics 2009 Oct 8;10 Suppl 11(Suppl 11):S8.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
