FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Antonie Van Leeuwenhoek / Precipitating antibodies against Micropolyspora faeni in equ...
Antonie van Leeuwenhoek1985; 51(3); 313-319; doi: 10.1007/BF02439940

Precipitating antibodies against Micropolyspora faeni in equines in north-western India.

Abstract: Prevalence of serum precipitins against Micropolyspora faeni, Thermoactinomyces vulgaris and Aspergillus fumigatus, employing the counterimmunoelectrophoresis (COIE) and Ouchterlony's double diffusion (DD) techniques, is reported in 162 of the equines stationed at two military installations in north-western India. M. faeni specific precipitins were demonstrable in 58 of 112 mules from site I in the mountainous region whereas the results were negative for all of the 50 horses examined from site II located in the plains. Of the 58 M. faeni positive mules, 45 (78%) had signs and symptoms suggestive of chronic obstructive pulmonary disease (COPD) while the remaining 13 (22%) were apparently free from any respiratory disorder. The more frequent occurrence of M. faeni precipitins in the symptomatic than in the asymptomatic group of mules was found to be statistically significant (P less than 0.01). Precipitins against A. fumigatus were concomitantly demonstrated in 5 of the mules afflicted with COPD and found to be positive for M. faeni.
Get Full Text
Publication Date: 1985-01-01 PubMed ID: 3937491DOI: 10.1007/BF02439940Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research studies the presence of specific antibodies against certain types of fungi in horses and mules in north-western India and their potential link to chronic respiratory diseases.

Methods and Samples

  • The researchers collected serum samples from 162 equines at two military installations in northwest India. These included 112 mules from a mountainous region (site I) and 50 horses from the plains (site II).
  • Two techniques – counterimmunoelectrophoresis (COIE) and Ouchterlony’s double diffusion (DD) – were employed to detect the presence of precipitins, or antibodies produced in response to specific antigens (in this case, fungal species).

Results and Findings

  • They noted the presence of precipitins against a fungal species, Micropolyspora faeni, in 58 mules from site I. No such precipitins were found in the horses at site II.
  • Among the M. faeni positive mules, 78% had symptoms of chronic obstructive pulmonary disease (COPD), while the rest showed no signs of any respiratory illness. Statistical analysis confirmed a significant correlation between the occurrence of M. faeni precipitins and symptoms of respiratory issues in mules.
  • Furthermore, antibodies against another fungus Aspergillus fumigatus were found concomitantly in five mules that were also positive for M. faeni precipitins and had COPD.

Implications and Conclusions

  • The results indicate the possibility of M. faeni and potentially A. fumigatus being involved in causing COPD in mules in this region. Their presence seems especially pronounced in the mountainous area, while absent in the plains.
  • These findings can help in further understanding of the disease mechanisms in these animals and potential solutions. It also underscores the importance of identifying environmental factors (like particular strains of fungi) that may contribute to chronic respiratory diseases in equines.

Cite This Article

APA
Khan ZU, Misra VC, Randhawa HS. (1985). Precipitating antibodies against Micropolyspora faeni in equines in north-western India. Antonie Van Leeuwenhoek, 51(3), 313-319. https://doi.org/10.1007/BF02439940

Publication

Antonie van Leeuwenhoek
ISSN: 0003-6072
NlmUniqueID: 0372625
Country: Netherlands
Language: English
Volume: 51
Issue: 3
Pages: 313-319

Researcher Affiliations

Khan, Z U
    Misra, V C
      Randhawa, H S

        MeSH Terms

        • Animals
        • Antibodies, Fungal / analysis
        • Horses / immunology
        • Immunodiffusion
        • Immunoelectrophoresis, Two-Dimensional
        • India
        • Micromonosporaceae / immunology
        • Precipitin Tests

        References

        This article includes 13 references
        1. Khan ZU, Sandhu RS, Randhawa HS, Menon MP, Dusaj IS. Allergic bronchopulmonary aspergillosis: a study of 46 cases with special reference to laboratory aspects.. Scand J Respir Dis 1976;57(2):73-87.
          pubmed: 821142
        2. McPherson EA, Thomson JR. Chronic obstructive pulmonary disease in the horse. 1: Nature of the disease.. Equine Vet J 1983 Jul;15(3):203-6.
          pubmed: 6884309doi: 10.1111/j.2042-3306.1983.tb01764.xgoogle scholar: lookup
        3. Hoehne JH, Reed CE, Dickie HA. Allergic bronchopulmonary aspergillosis is not rare. With a note on preparation of antigen for immunologic tests.. Chest 1973 Feb;63(2):177-81.
          pubmed: 4631688doi: 10.1378/chest.63.2.177google scholar: lookup
        4. Lawson GH, McPherson EA, Murphy JR, Nicholson JM, Wooding P, Breeze RG, Pirie HM. The presence of precipitating antibodies in the sera of horses with chronic obstructive pulmonary disease (COPD).. Equine Vet J 1979 Jul;11(3):172-6.
          pubmed: 114387doi: 10.1111/j.2042-3306.1979.tb01334.xgoogle scholar: lookup
        5. Thomson JR, McPherson EA. Chronic obstructive pulmonary disease in the horse. 2: Therapy.. Equine Vet J 1983 Jul;15(3):207-10.
          pubmed: 6411459doi: 10.1111/j.2042-3306.1983.tb01766.xgoogle scholar: lookup
        6. McPherson EA, Lawson GH, Murphy JR, Nicholson JM, Breeze RG, Pirie HM. Chronic obstructive pulmonary disease (COPD) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge.. Equine Vet J 1979 Jul;11(3):159-66.
          pubmed: 385306doi: 10.1111/j.2042-3306.1979.tb01330.xgoogle scholar: lookup
        7. PEPYS J, JENKINS PA, FESTENSTEIN GN, GREGORY PH, LACEY ME, SKINNER FA. FARMER'S LUNG. THERMOPHILIC ACTINOMYCETES AS A SOURCE OF "FARMER'S LUNG HAY" ANTIGEN.. Lancet 1963 Sep 21;2(7308):607-11.
          pubmed: 14054440doi: 10.1016/s0140-6736(63)90398-2google scholar: lookup
        8. Pepys J. Hypersensitivity diseases of the lungs due to fungi and organic dusts.. Monogr Allergy 1969;4:1-147.
          pubmed: 5005677
        9. Patterson R, Roberts M. IgE and IgG antibodies against Aspergillus fumigatus in sera of patients with bronchopulmonary allergic aspergillosis.. Int Arch Allergy Appl Immunol 1974;46(1):150-60.
          pubmed: 4205309doi: 10.1159/000231119google scholar: lookup
        10. Murphy JR, McPherson EA, Lawson GH. The effects of sodium cromoglycate on antigen inhalation challenge in two horses affected with chronic obstructive pulmonary disease (COPD).. Vet Immunol Immunopathol 1979 Nov;1(1):89-95.
          pubmed: 15612272doi: 10.1016/0165-2427(79)90010-2google scholar: lookup
        11. Pirie HM, Dawson CO, Breeze RG, Wiseman A, Hamilton J. A bovine disease similar to farmer's lung: extrinsic allergic alveolitis.. Vet Rec 1971 Apr 3;88(14):346-51.
          pubmed: 4252199doi: 10.1136/vr.88.14.346google scholar: lookup
        12. Lacey J. The microflora of fodders associated with bovine respiratory disease.. J Gen Microbiol 1968 Apr;51(2):173-7.
          pubmed: 5652092doi: 10.1099/00221287-51-2-173google scholar: lookup
        13. Wilkie BN. Bovine allergic pneumonitis: an acute outbreak associated with mouldy hay.. Can J Comp Med 1978 Jan;42(1):10-5.
          pubmed: 647448

        Citations

        This article has been cited 3 times.
        1. Khan ZU, Gangwar M, Gaur SN, Randhawa HS. Thermophilic actinomycetes in cane sugar mills: an aeromicrobiologic and seroepidemiologic study. Antonie Van Leeuwenhoek 1995;67(4):339-44.
          doi: 10.1007/BF00872932pubmed: 7574549google scholar: lookup
        2. Gangwar M, Khan ZU, Randhawa HS, Lacey J. Distribution of clinically important thermophilic actinomycetes in vegetable substrates and soil in north-western India. Antonie Van Leeuwenhoek 1989 Oct;56(3):201-9.
          doi: 10.1007/BF00418932pubmed: 2589849google scholar: lookup
        3. Gangwar M, Khan ZU, Gaur SN, Randhawa HS. Occurrence and significance of precipitating antibodies against thermophilic actinomycetes in the sera of dairy herd workers, Nangali, Delhi. Antonie Van Leeuwenhoek 1991 Apr;59(3):167-75.
          doi: 10.1007/BF00580656pubmed: 1867472google scholar: lookup
        Subscribe to our newsletter
        Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.