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Home / Equine Research Bank / Infect Immun / Precipitating cross-reactions among pneumococcal types.
Infection and immunity1983; 41(3); 1234-1244; doi: 10.1128/iai.41.3.1234-1244.1983

Precipitating cross-reactions among pneumococcal types.

Abstract: Data accumulated over many years are brought together on cross-reactions of 46 among the more than 80 pneumococcal serological types, with the idea of correlating cross-reactions with the structures of the relevant type-specific capsular polysaccharides, insofar as these have been determined. The precipitin reaction was carried out with the polysaccharides and antibodies raised in horses, rabbits, and a mule. Quantitative values (micrograms of antibody nitrogen per milliliter of antiserum at 0 to 1 degree C) are given in many instances and discussed, together with arbitrary qualitative data, in terms of the known structures of the polysaccharides. Some precise relationships are uncovered, and an attempt is made to determine why some of the cross-reactions are reciprocal and why others are only unilateral.
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Publication Date: 1983-09-01 PubMed ID: 6885161PubMed Central: PMC264631DOI: 10.1128/iai.41.3.1234-1244.1983Google Scholar: Lookup
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  • U.S. Gov't
  • Non-P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper consolidates many years of data on how certain types of pneumococcal bacteria react to each other and to the structures of specific polysaccharides found on their capsules. The researchers use these insights to explain why some reactions are equal and two-way, while others are one-sided.

Background and Objective of the Study

  • The paper is a comprehensive analysis conducted on the basis of data collected over a lengthy period. The primary focus is on the cross-reactions among 46 out of the more than 80 pneumococcal serological types.
  • The objective was to understand the correlation between these cross-reactions and the structures of the respective type-specific capsular polysaccharides – the complex sugars that form a protective layer around each bacteria. The main aim was to uncover relationships and figure out the reason behind the reciprocity or unilaterality of these cross-reactions.

Methodology

  • The precipitin reaction, which is a test designed to reveal the presence of specific antibodies in a serum, was utilized to study the reactions between the polysaccharides and antibodies.
  • These antibodies were raised in host organisms, specifically horses, rabbits, and a mule, to see how they respond to the pneumococcal types.

Key Findings and Discussion

  • The paper provides both quantitative and qualitative data. Quantitative values are presented in many cases (measuring antibody nitrogen per milliliter of antiserum at 0 to 1 degree C).
  • The results are discussed in the context of the known structures of the polysaccharides involved. This helps to bring some precision to the relationships identified.
  • The research found both reciprocal and unilateral reactions. Reciprocal reactions are those where both pneumococcal types react to each other equally, while unilateral reactions are those where only one type responds to the other.
  • While the research uncovered some relationships, the paper indicates an ongoing attempt to comprehend why certain cross-reactions are reciprocal and others are unilateral.

Significance of the Study

  • Understanding how these bacteria types react to one another and why they do so in particular ways can provide crucial insights into pneumococcal bacteria behaviour. This, in turn, can potentially inform new strategies for combating pneumococcal disease.

Cite This Article

APA
Heidelberger M. (1983). Precipitating cross-reactions among pneumococcal types. Infect Immun, 41(3), 1234-1244. https://doi.org/10.1128/iai.41.3.1234-1244.1983

Publication

Infection and immunity
ISSN: 0019-9567
NlmUniqueID: 0246127
Country: United States
Language: English
Volume: 41
Issue: 3
Pages: 1234-1244

Researcher Affiliations

Heidelberger, M

    MeSH Terms

    • Cross Reactions
    • Polysaccharides, Bacterial / immunology
    • Precipitin Tests
    • Serotyping
    • Streptococcus pneumoniae / classification
    • Streptococcus pneumoniae / immunology
    • Structure-Activity Relationship
    • Temperature

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