Preoperative administration of hydroxyethyl starch or hypertonic saline to horses with colic.
Abstract: Hypertonic saline and hydroxyethyl starches have been proposed as alternatives to isotonic crystalloids for reversal of hypovolemia in horses with colic. However, no direct comparison of these fluids has been performed in a clinical setting. Objective: Preoperative administration of hypertonic saline or pentastarch would produce similar effects on intra operative hemodynamics in horses with colic. Methods: Thirty horses requiring colic surgery were enrolled in this prospective, randomized, open-label clinical trial. Inclusion criteria were owner consent, and at least 2 of 3 clinicopathologic abnormalities: packed cell volume >45%, plasma total solid concentration >8.0 g/dL, and blood lactate concentration >2.5 mM. Methods: Study horses were randomly assigned to receive 4 mL/kg hypertonic saline or pentastarch before induction of anesthesia. Hemodynamic measurements were recorded every 30 minutes during anesthesia. Cardiac output (CO) was measured by the lithium dilution method. CO and stroke volume (SV) were indexed by body weight. Data were analysed using repeated measures analysis of variance (ANOVA). Post hoc comparisons were performed using the Bonferroni test. Results: Cardiac index (CI) was higher in the pentastarch group compared with the hypertonic saline group from 30 to 150 minutes after induction (P = .04). SV index was higher in the pentastarch group at 30 (P = .025) and 60 minutes (P = .04). Mean arterial pressure of horses in both groups was lower at 90 minutes compared with 30 and 60 minutes. Conclusions: Preoperative administration of pentastarch results in better CI than hypertonic saline, for 150 minutes after anesthetic induction. The effect of this improved global blood flow on regional perfusion or clinical outcome remains to be elucidated.
Publication Date: 2006-09-08 PubMed ID: 16955826DOI: 10.1892/0891-6640(2006)20[980:paohso]2.0.co;2Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This research article is about a trial comparing the effects of two preoperative treatments, hydroxyethyl starch (pentastarch) and hypertonic saline, on horses with colic requiring surgery. It concludes that pentastarch results in a better Cardiac Index (CI) than hypertonic saline for up to 150 minutes after anesthetic induction.
Objective and Methods
- The research’s objective was to determine whether preoperative administration of hypertonic saline or pentastarch has similar effects on intraoperative hemodynamics in horses undergoing colic surgery.
- The researchers set up a prospective, randomized, open-label clinical trial. Thirty horses meeting certain clinicopathologic criteria—such as a high packed cell volume or blood lactate concentration—were enrolled in the study with their owners’ consent.
- The horses were randomly assigned to receive either hypertonic saline or pentastarch before induction of anesthesia.
- Hemodynamic measurements, including Cardiac Output (CO) and Stroke Volume (SV), were taken every thirty minutes during anesthesia. The CO was measured using the lithium dilution method, and both the CO and SV were indexed by the horses’ body weight.
- The data collected were analysed using repeated measures analysis of variance (ANOVA), and post hoc comparisons were performed using the Bonferroni test.
Results
- The results showed that the cardiac index (CI) was higher in the pentastarch group, compared to the hypertonic saline group, for 150 minutes after anesthetic induction.
- The stroke volume index (SVI) was also found to be higher in the pentastarch group at 30 minutes and 60 minutes.
- The mean arterial pressure of horses in both groups was however lower at 90 minutes compared with 30 and 60 minutes.
Conclusions
- The study concludes that pentastarch results in a better CI than hypertonic saline for up to 150 minutes after anesthetic induction.
- However, the effect of this improved global blood flow on regional perfusion or clinical outcome has not been established and remains to be studied further.
Cite This Article
APA
Hallowell GD, Corley KT.
(2006).
Preoperative administration of hydroxyethyl starch or hypertonic saline to horses with colic.
J Vet Intern Med, 20(4), 980-986.
https://doi.org/10.1892/0891-6640(2006)20[980:paohso]2.0.co;2 Publication
Researcher Affiliations
- Equine Referral Hospital, Royal Veterinary College, North Mymms, Herts, UK.
MeSH Terms
- Animals
- Colic / complications
- Colic / therapy
- Colic / veterinary
- Horse Diseases / therapy
- Horses
- Hydroxyethyl Starch Derivatives / administration & dosage
- Hydroxyethyl Starch Derivatives / therapeutic use
- Hypotension / complications
- Hypotension / therapy
- Hypotension / veterinary
- Preoperative Care / veterinary
- Saline Solution, Hypertonic / administration & dosage
- Saline Solution, Hypertonic / therapeutic use
Citations
This article has been cited 2 times.- Epstein KL, Bergren A, Giguère S, Brainard BM. Cardiovascular, colloid osmotic pressure, and hemostatic effects of 2 formulations of hydroxyethyl starch in healthy horses. J Vet Intern Med 2014 Jan-Feb;28(1):223-33.
- Gomez DE, Kopper JJ, Byrne DP, Renaud DL, Schoster A, Dunkel B, Arroyo LG, Mykkanen A, Gilsenan WF, Pihl TH, Lopez-Navarro G, Tennent-Brown BS, Hostnik LD, Mora-Pereira M, Marques F, Gold JR, DeNotta SL, Desjardins I, Stewart AJ, Kuroda T, Schaefer E, Oliver-Espinosa OJ, Agne GF, Uberti B, Veiras P, Delph Miller KM, Gialleti R, John E, Toribio RE. Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study. PLoS One 2024;19(11):e0313783.
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