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Home / Equine Research Bank / Arch Virol / Prevalence of G and P serotypes among equine rotaviruses in ...
Archives of virology1996; 141(6); 1077-1089; doi: 10.1007/BF01718611

Prevalence of G and P serotypes among equine rotaviruses in the faeces of diarrhoeic foals.

Abstract: Variant types of VP4 and VP7 gene segments of faecal rotaviruses from diarrhoeic foals were identified by restriction endonuclease digestion of reverse transcription/polymerase chain reaction (RT/PCR) products. The variants observed were correlated with serotypes by determination of the sequence of representative RT/PCR products (entire coding sequence for VP7 and the VP8 region of VP4) and comparison to published sequences of equine G and P serotype genes. Both G and P serotypes could be predicted for 95/116 (82%) strains, P serotype only for a further 8 (7%) strains and G serotype only for 1 (1%) strain. All characterised strains belonged to the same P serotype, P12, although minor sequence variations were observed. Of those strains able to be assigned to G serotypes, 84/96 (87.5%) belonged to serotype G3A, and 12/96 (12.5%) belonged to serotype G14. Comparison of G serotyping by ELISA to the RT/PCR method showed that serotyping equine rotaviruses by currently available ELISA methods was prone to error. This study establishes the restricted serotypic diversity of equine rotaviruses, and the significance of serotype G14.
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Publication Date: 1996-01-01 PubMed ID: 8712925DOI: 10.1007/BF01718611Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the prevalence of G and P serotypes among rotaviruses in the faeces of horses with diarrhoea. The study identifies the types of variant segments of the rotavirus genes in these samples, finding a limited diversity of serotypes, with a significant prevalence of serotype G14.

Methodology

  • The researchers identified variant types of VP4 and VP7 gene segments of faecal rotaviruses found in diarrhoeic foals. They used restriction endonuclease digestion of reverse transcription/polymerase chain reaction (RT/PCR) products to do so.
  • The observed variants were then correlated with specific serotypes by determining the sequence of representative RT/PCR products. Specifically, they examined the entire coding sequence for VP7 and the VP8 region of VP4.
  • They compared these sequences to published sequences of equine G and P serotype genes to establish the serotype of the observed variants.

Findings

  • For a majority of the strains (82%), they could predict both G and P serotypes. For a further 7% of the strains, only the P serotype could be identified, and for just 1% of the strains, only the G serotype could be discerned.
  • All the characterised strains belonged to the P serotype P12, although there were minor sequence variations observed within this serotype.
  • Of those strains for which G serotypes could be assigned, 87.5% belonged to serotype G3A, and 12.5% belonged to serotype G14.

Comparative Analysis of Serotyping Methods

  • A comparison was carried out between G serotyping performed via ELISA to that conducted with the RT/PCR method.
  • The results indicated that serotyping equine rotaviruses using currently available ELISA methods was prone to errors.

Conclusion

  • This study provides crucial insight into the constrained serotypic diversity among equine rotaviruses.
  • It highlights the significance of serotype G14, suggested by its higher prevalence among the studied strains.

Cite This Article

APA
Browning GF, Begg AP. (1996). Prevalence of G and P serotypes among equine rotaviruses in the faeces of diarrhoeic foals. Arch Virol, 141(6), 1077-1089. https://doi.org/10.1007/BF01718611

Publication

Archives of virology
ISSN: 0304-8608
NlmUniqueID: 7506870
Country: Austria
Language: English
Volume: 141
Issue: 6
Pages: 1077-1089

Researcher Affiliations

Browning, G F
  • Veterinary Preclinical Centre, Faculty of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
Begg, A P

    MeSH Terms

    • Amino Acid Sequence
    • Animals
    • Antibodies, Viral / immunology
    • Antigens, Viral
    • Base Sequence
    • Capsid / genetics
    • Capsid / immunology
    • Capsid Proteins
    • DNA, Viral
    • Diarrhea / veterinary
    • Diarrhea / virology
    • Feces / virology
    • Genetic Variation
    • Horses
    • Molecular Sequence Data
    • Polymerase Chain Reaction
    • Restriction Mapping
    • Rotavirus / classification
    • Rotavirus / genetics
    • Rotavirus / isolation & purification
    • Rotavirus Infections / veterinary
    • Rotavirus Infections / virology
    • Sequence Homology, Amino Acid
    • Serotyping

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