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Home / Equine Research Bank / Adv Drug Deliv Rev / Progress in cell-based therapies for tendon repair.
Advanced drug delivery reviews2014; 84; 240-256; doi: 10.1016/j.addr.2014.11.023

Progress in cell-based therapies for tendon repair.

Abstract: The last decade has seen significant developments in cell therapies, based on permanently differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative conditions. In vitro studies assess the influence of biophysical, biochemical and biological signals on tenogenic phenotype maintenance and/or differentiation towards tenogenic lineage. However, the ideal culture environment has yet to be identified due to the lack of standardised experimental setup and readout system. Bone marrow mesenchymal stem cells and tenocytes/dermal fibroblasts appear to be the cell populations of choice for clinical translation in equine and human patients respectively based on circumstantial, rather than on hard evidence. Collaborative, inter- and multi-disciplinary efforts are expected to provide clinically relevant and commercially viable cell-based therapies for tendon repair and regeneration in the years to come.
Copyright © 2014 Elsevier B.V. All rights reserved.
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Publication Date: 2014-12-24 PubMed ID: 25543005DOI: 10.1016/j.addr.2014.11.023Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article delves into the progress made over the last decade in the use of cell therapies to treat tendon injuries and conditions. It explains how stem cells have been manipulated and modified for these treatments, and while some results are promising, further work is needed to identify the best approach.

Research Focus

  • The paper focuses on recent advances in the use of cell therapies for tendon injuries and degenerative conditions. Specifically, the use of permanently differentiated, reprogrammed, or engineered stem cells is explored.

Current Findings

  • In lab conditions, researchers have been working to understand how different types of signals – biophysical, biochemical, and biological – can influence a cell’s abilities to either maintain its tenogenic (tendon-forming) properties or differentiate into a tenogenic lineage.
  • Presently, the “ideal culture environment”, that is, the best conditions under which to grow these cells, has not been found since there is no standardization in the experimental setup and readout system across different researches.

Specific Cell Types

  • The paper states that bone marrow mesenchymal stem cells and tenocytes/dermal fibroblasts appear to be the cell populations of choice for clinical trials for equine and human patients. This inference is based on circumstantial evidence rather than hard scientific data.

Future Direction

  • The research acknowledges the need for further study and greater collaboration between multiple scientific disciplines. This cooperation is critical to advance the field and eventually develop clinically relevant and commercially viable cell-based therapies that can effectively repair and regenerate tendons.

Cite This Article

APA
Gaspar D, Spanoudes K, Holladay C, Pandit A, Zeugolis D. (2014). Progress in cell-based therapies for tendon repair. Adv Drug Deliv Rev, 84, 240-256. https://doi.org/10.1016/j.addr.2014.11.023

Publication

Advanced drug delivery reviews
ISSN: 1872-8294
NlmUniqueID: 8710523
Country: Netherlands
Language: English
Volume: 84
Pages: 240-256
PII: S0169-409X(14)00307-X

Researcher Affiliations

Gaspar, Diana
  • Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
Spanoudes, Kyriakos
  • Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
Holladay, Carolyn
  • Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
Pandit, Abhay
  • Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
Zeugolis, Dimitrios
  • Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland. Electronic address: dimitrios.zeugolis@nuigalway.ie.

MeSH Terms

  • Animals
  • Cell Culture Techniques / methods
  • Cell- and Tissue-Based Therapy / methods
  • Cell- and Tissue-Based Therapy / veterinary
  • Humans
  • Regeneration / physiology
  • Tendons / physiology

Citations

This article has been cited 55 times.
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