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Home / Equine Research Bank / Can Vet J / Prostaglandin F2alpha treatment of cyclic dysfunction in mar...
The Canadian veterinary journal = La revue veterinaire canadienne1976; 17(12); 301-307;

Prostaglandin F2alpha treatment of cyclic dysfunction in mares.

Abstract: THE ABILITY OF PROSTAGLANDIN (PG)F2a and its synthetic analogues to induce luteolysis in the mare has been adequately demonstrated (3, 6). This luteolytic effect has been utilized in the treatment of several forms of cyclic dysfunction encountered in horse breeding. It has been shown that a high proportion of Thoroughbred mares with persistent luteal function (prolonged diestrus) treated with PCF2a analogues will come into estrus within four days of treatment and that they will ovulate normally (4, 10). Thus PG treatment of mares which exhibit aberrant estrous cycles during the breeding season provides a method for improving overall pregnancy rates and re-ducing the foaling-conception interval in indi-vidual mares. None of the published data available to date has assessed the benefits of PC therapy to individual breeding establish-ments. This paper describes the results ob-tained following treatment of problem mares on a large Thoroughbred farm in Ontario dur-ing the 1975 breeding season.
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Publication Date: 1976-12-01 PubMed ID: 1000459PubMed Central: PMC1697410
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article primarily investigates the effectiveness of Prostaglandin F2alpha (PGF2α) and its synthetic counterparts in treating cyclic dysfunctions in mares, aiming to improve pregnancy rates and decrease the foaling-conception interval.

Research Focus and Rationale

  • The study is centered on the use of Prostaglandin F2alpha (PGF2α), and its synthetic analogues in addressing several forms of cyclic dysfunction in mares, essentially those linked with horse breeding.
  • Prior research has shown that PGF2α is capable of inducing luteolysis, a process that leads to the regression of the corpus luteum, a structure integral to pregnancy in mammals.
  • The application of this effect has been seen in mares with prolonged diestrus or persistent luteal function. Treating these mares with PGF2α analogues has shown to bring them into estrus (a period of sexual receptivity) within four days of treatment, allowing them to ovulate normally.
  • The authors suggest that such treatment can help regulate aberrant estrous cycles in mares, potentially enhancing overall pregnancy rates and decreasing the time period between foaling and conception.

Research Gap

  • Despite the promising results of PGF2α treatment, the authors highlight a gap in the existing research. No studies to date have assessed the specific benefits of this treatment to individual breeding establishments.
  • The need for such an assessment forms the basis of this research paper, aiming to contribute well-rounded data on the practical implications of PGF2α therapy for breeding mares in real-world scenarios.

Methodology and Context

  • The paper recounts the results acquired after administering PGF2α treatment on a large Thoroughbred farm in Ontario during the 1975 breeding season.
  • This approach provides a practical perspective on the effectiveness of PGF2α treatments, where field data contributes to a more comprehensive understanding of its potential benefits and implications for horse breeding.

Cite This Article

APA
Mitchell D, de Gannes R, Sugden EA. (1976). Prostaglandin F2alpha treatment of cyclic dysfunction in mares. Can Vet J, 17(12), 301-307.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 17
Issue: 12
Pages: 301-307

Researcher Affiliations

Mitchell, D
    de Gannes, R
      Sugden, E A

        MeSH Terms

        • Animals
        • Estrus / drug effects
        • Female
        • Horses / physiology
        • Pregnancy
        • Prostaglandins F / pharmacology

        References

        This article includes 15 references
        1. Squires EL, Wentworth BC, Ginther OJ. Progesterone concentration in blood of mares during the estrous cycle, pregnancy and after hysterectomy.. J Anim Sci 1974 Oct;39(4):759-67.
          pubmed: 4415322doi: 10.2527/jas1974.394759xgoogle scholar: lookup
        2. Kenney RM, Ganjam VK, Cooper WL, Lauderdale JW. The use of prostaglandin F2alpha-tham salt in mares in clinical anoestrus.. J Reprod Fertil Suppl 1975 Oct;(23):247-50.
          pubmed: 1060786
        3. Allen WR, Rossdale PD. A preliminary study upon the use of prostaglandins for inducing oestrus in non-cycling thoroughbred mares.. Equine Vet J 1973 Oct;5(4):137-40.
          pubmed: 4766686doi: 10.1111/j.2042-3306.1973.tb03213.xgoogle scholar: lookup
        4. Abraham GE, Swerdloff R, Tulchinsky D, Odell WD. Radioimmunoassay of plasma progesterone.. J Clin Endocrinol Metab 1971 May;32(5):619-24.
          pubmed: 5577881doi: 10.1210/jcem-32-5-619google scholar: lookup
        5. Berwyn-Jones MD, Irvine CH. Induction of luteolysis and oestrus in mares with a synthetic prostaglandin analogue (ICI 81008).. N Z Vet J 1974 Jul;22(7):107-10.
          pubmed: 4530940doi: 10.1080/00480169.1974.34145google scholar: lookup
        6. Rodbard D. Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays.. Clin Chem 1974 Oct;20(10):1255-70.
          pubmed: 4370388
        7. Stabenfeldt GH, Hughes JP, Evans JW. Ovarian activity during the estrous cycle of the mare.. Endocrinology 1972 May;90(5):1379-84.
          pubmed: 5062475doi: 10.1210/endo-90-5-1379google scholar: lookup
        8. Allen WR, Rowson LE. Control of the mare's oestrous cycle by prostaglandins.. J Reprod Fertil 1973 Jun;33(3):539-43.
          pubmed: 4736562doi: 10.1530/jrf.0.0330539google scholar: lookup
        9. Oxender WD, Noden PA, Hafs HD. Oestrus, ovulation and plasma hormones after prostaglandin F2alpha in mares.. J Reprod Fertil Suppl 1975 Oct;(23):251-5.
          pubmed: 1060787
        10. Douglas RH, Ginther OJ. Effects of prostaglandin F2alpha on the oestrous cycle and pregnancy in mares.. J Reprod Fertil Suppl 1975 Oct;(23):257-61.
          pubmed: 1060788
        11. Palmer E, Jousset B. Synchronization of oestrus in mares with a prostaglandin analogue and HCG.. J Reprod Fertil Suppl 1975 Oct;(23):269-74.
          pubmed: 1060790
        12. Nelson AM. The therapeutic activity, post-treatment fertility and safety of prostaglandin F2alpha-Tham salt in clinically anoestrous mares: a review.. Equine Vet J 1976 Apr;8(2):75-7.
          pubmed: 770159doi: 10.1111/j.2042-3306.1976.tb03297.xgoogle scholar: lookup
        13. Frhr J, Lepel V. Maintenance of fertility in the horse including artificial insemination.. Equine Vet J 1975 Apr;7(2):97-101.
          pubmed: 1095367doi: 10.1111/j.2042-3306.1975.tb03242.xgoogle scholar: lookup
        14. Douglas RH, Ginther OJ. Effect of prostaglandin F2alpha on length of diestrus in mares.. Prostaglandins 1972 Oct;2(4):265-8.
          pubmed: 4677341doi: 10.1016/s0090-6980(72)80014-5google scholar: lookup
        15. Allen WR, Stewart F, Cooper MJ, Crowhurst RC, Simpson DJ, McEnery RJ, Greenwood RE, Rossdale PD, Ricketts SW. Further studies on the use of synthetic prostaglandin analogues for inducing luteolysis in mares.. Equine Vet J 1974 Jan;6(1):31-5.
          pubmed: 4856510doi: 10.1111/j.2042-3306.1974.tb03925.xgoogle scholar: lookup

        Citations

        This article has been cited 0 times.
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