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Home / Equine Research Bank / Can J Vet Res / Pulsed radio frequency therapy of experimentally induced art...
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire1991; 55(1); 76-85;

Pulsed radio frequency therapy of experimentally induced arthritis in ponies.

Abstract: The effect of pulsed radio frequency therapy (PRFT) was evaluated on seven ponies with no arthritis and in 28 ponies in which arthritis was created using intra-articular amphotericin B to induce synovitis in the right middle carpal joint. The ponies were divided into five treatment and two control groups. Two levels of arthritis were created and two dosage levels of PRFT were evaluated. The effect of PRFT on arthritic and nonarthritic joints was measured by comparing synovial fluid parameters, the degree and duration of lameness, the range of carpal motion, and carpus circumference, for treated and untreated groups. Lesions seen radiographically, at gross pathology, and by histopathology were also compared between the treated and control groups. In the ponies with a mild form of induced arthritis, PRFT significantly (p less than 0.05) reduced the severity and duration of lameness, swelling of the carpus, and the severity of gross pathological and radiographic changes. In these ponies the synovial acid phosphatase levels were lower, the mucin clot quality was superior, and the synovial protein levels were lower for the ponies receiving PRFT as compared to the arthritic ponies receiving no treatment. A dose response effect was evident. In ponies with a slightly more severe form of arthritis, PRFT was evaluated at one dosage level. The treated ponies were significantly improved over the untreated ponies with respect to carpal range of motion, degree of lameness, carpus swelling, and radiographic lesions. No deleterious effects were noted when normal, PRFT treated, middle carpal joints were compared to contralateral untreated, normal joints. It was concluded that significant beneficial effects resulted when affected ponies were treated with PRFT.
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Publication Date: 1991-01-01 PubMed ID: 1884288PubMed Central: PMC1263418
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates whether pulsed radio frequency therapy (PRFT) can help treat induced arthritis in ponies. The results indicate that PRFT can effectively reduce severity and duration of lameness, swelling, and other symptoms associated with arthritis without showing any detrimental side effects.

Methodology

  • The researchers created a sample population of 35 ponies, seven of which were healthy and 28 had arthritis induced using intra-articular amphotericin B.
  • The 28 arthritis-affected ponies and the control group of healthy ponies were then divided into five treatment groups, and two control groups.
  • The severity level of arthritis and the dosage of PRFT were varied across two sets of ponies which were monitored for differences in synovial fluid parameters, extent and duration of lameness, range of carpal movement, and carpus circumference.

Results

  • In ponies suffering from a mild form of arthritis, PRFT was found to remarkably decrease the severity and duration of lameness, swelling of the carpus, and the severity of gross pathological and radiographic changes.
  • Such ponies also showed lower synovial acid phosphatase levels, enhanced mucin clot quality, and decreased synovial protein levels in comparison to arthritic ponies receiving no treatment.
  • The study observed a dose-response effect, suggesting that the effectiveness of PRFT was dependent on the dosage levels.

Evaluation of Severe Arthritis & Normal Joints

  • In ponies suffering from a slightly severe form of arthritis, a single dosage level of PRFT was evaluated. The treated ponies showed significant improvement in terms of carpal range of motion, degree of lameness, carpal swelling, and radiographic lesions compared to untreated ponies.
  • No harmful effects were observed when comparing mid-carpal joints treated with PRFT in healthy ponies to untreated carpal joints on the opposite side.

Conclusions

  • The study conclusively found significant beneficial effects when ponies with induced arthritis were treated with PRFT. With the observed benefits and absence of any deleterious effects, it was concluded that PRFT could potentially serve as a superior treatment for relieving arthritis-related issues in ponies.

Cite This Article

APA
Crawford WH, Houge JC, Neirby DT, Di Mino A, Di Mino AA. (1991). Pulsed radio frequency therapy of experimentally induced arthritis in ponies. Can J Vet Res, 55(1), 76-85.

Publication

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
ISSN: 0830-9000
NlmUniqueID: 8607793
Country: Canada
Language: English
Volume: 55
Issue: 1
Pages: 76-85

Researcher Affiliations

Crawford, W H
  • Department of Surgical Science, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
Houge, J C
    Neirby, D T
      Di Mino, A
        Di Mino, A A

          MeSH Terms

          • Animals
          • Arthritis / radiotherapy
          • Arthritis / veterinary
          • Carpus, Animal
          • Dose-Response Relationship, Radiation
          • Horse Diseases / radiotherapy
          • Horses
          • Lameness, Animal / radiotherapy
          • Radio Waves

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          Citations

          This article has been cited 5 times.
          1. Story MR, Haussler KK, Nout-Lomas YS, Aboellail TA, Kawcak CE, Barrett MF, Frisbie DD, McIlwraith CW. Equine Cervical Pain and Dysfunction: Pathology, Diagnosis and Treatment. Animals (Basel) 2021 Feb 6;11(2).
            doi: 10.3390/ani11020422pubmed: 33562089google scholar: lookup
          2. LaVallee KT, Maus TP, Stock JD, Stalder KJ, Karriker LA, Murthy NS, Kanwar R, Beutler AS, Unger MD. Quantitation of Gait and Stance Alterations Due to Monosodium Iodoacetate-induced Knee Osteoarthritis in Yucatan Swine. Comp Med 2020 Jun 1;70(3):248-257.
            doi: 10.30802/AALAS-CM-19-000075pubmed: 32331555google scholar: lookup
          3. El-Denshary ES, Rashed LA, Elhussiny M. Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model. Clin Exp Med 2014 Aug;14(3):285-95.
            doi: 10.1007/s10238-013-0248-3pubmed: 23990050google scholar: lookup
          4. Mokbel AN, El Tookhy OS, Shamaa AA, Rashed LA, Sabry D, El Sayed AM. Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model. BMC Musculoskelet Disord 2011 Nov 15;12:259.
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          5. Bok J, Kim ES, Ha J, Lee DM, Ahn BJ, Lee SW, Cho SH, Kim NY, Jang Y. Non-contact radiofrequency stimulation to the olfactory nerve of human subjects. APL Bioeng 2025 Sep;9(3):036112.
            doi: 10.1063/5.0275613pubmed: 40842699google scholar: lookup
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