Pyogenic granuloma of the cornea in a pony: Uncommon complication of corneal wound healing.
Abstract: A 6-year-old miniature Shetland pony mare was referred for evaluation of a left corneal mass, which developed from the healing tissue of a corneal traumatic ulceration that had occurred 4 weeks previously. On gross examination, a spherical, smooth-surfaced, and pink-colored lesion of about 1 cm in diameter was protruding from the left palpebral fissure. Ophthalmic examination revealed that it was attached to the scar tissue of the cornea, and that one corpora nigra was adherent to the posterior face of corneal wounded area, without sign of uveitis. The remainder of the ophthalmic examination was unremarkable. The mass was excised, and cryotherapy was used as an adjunctive therapy. Histopathology of the resected mass was consistent with a pyogenic granuloma on the basis of radially oriented proliferating capillaries, embedded in immature granulation tissue containing an infiltrate of neutrophils, plasma cells and eosinophils. There were no histological features of malignancy. 2 months after surgery, the ventral part of the fibrotic corneal scar was slightly raised by a pink tissue, suggesting possible recurrence of the initial lesion. A second cryotherapy was performed over the leukoma area. No recurrence has been noted for a follow-up period of more than 25 months. Pyogenic granuloma is a benign proliferative fibrovascular response that typically develops after trauma or surgery. Corneal involvement is rare in humans, and to the authors' knowledge has never been documented in veterinary ophthalmology.
© 2022 American College of Veterinary Ophthalmologists.
Publication Date: 2022-11-22 PubMed ID: 36413443DOI: 10.1111/vop.13041Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Case Reports
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research involves the treatment of a six-year-old miniature Shetland pony mare who developed a pyogenic granuloma on her cornea following a traumatic injury. Following surgical removal and cryotherapy treatment, the granuloma recurred but was again treated successfully with no recurrences noted over a 25-month follow-up period.
Background
- A pyogenic granuloma is a benign fibrovascular response often noted to occur after surgical procedures or trauma. Although they are considered benign, they can cause discomfort and interfere with vision and are thus typically removed.
- This study is significant because corneal involvement of pyogenic granulomas is rare even in humans, and to the author’s knowledge, it has never been documented in veterinary ophthalmology before.
Case Report
- The subject was a six-year-old miniature Shetland pony mare who had developed a spherical, smooth, and pink lesion about 1 cm in diameter, which was observed to protrude from the left palpebral fissure.
- The ophthalmic examination revealed that the lesion was attached to scar tissue from a previous corneal ulceration the mare had experienced four weeks earlier. Additionally, one corpora nigra adhered to the posterior face of the corneal wounded area, without a sign of uveitis.
Treatment and Results
- The team decided to remove the mass surgically and applied cryotherapy as an adjunctive therapy.
- On histopathological examination, the mass was consistent with a diagnosis of pyogenic granuloma due to the presence of radially oriented proliferating capillaries that were present inside granulation tissue containing neutrophils, plasma cells, and eosinophils.
- Two months after the surgery, the team noted a small elevation in the fibrotic corneal scar, which was again treated with cryotherapy.
- For over 25 months following the second cryosurgery, no recurrence of the granuloma was noted.
Conclusion
- This case report provides valuable insight into an uncommon corneal complication following trauma in equine patients.
- It indicates that cryotherapy, when used in conjunction with surgical resection, can help to effectively manage such granulomas with minimal risk of recurrence.
Cite This Article
APA
Regnier A, Landrevie C, Robin MC, Einsweiler D, Douet JY, Raymond-Letron I.
(2022).
Pyogenic granuloma of the cornea in a pony: Uncommon complication of corneal wound healing.
Vet Ophthalmol, 26(1), 62-70.
https://doi.org/10.1111/vop.13041 Publication
Researcher Affiliations
- CHUVAC, Université de Toulouse, ENVT, Toulouse, France.
- CHUVAC, Université de Toulouse, ENVT, Toulouse, France.
- CHUVAC, Université de Toulouse, ENVT, Toulouse, France.
- Vet Equid, Servian, France.
- CHUVAC, Université de Toulouse, ENVT, Toulouse, France.
- IHAP, Université de Toulouse, INRAE, ENVT, Toulouse, France.
- LabHPEC, Université de Toulouse, ENVT, Toulouse, France.
- Institut Restore, Université de Toulouse, CNRS U-5070, EFS, ENVT, Inserm U1031, Toulouse, France.
MeSH Terms
- Horses
- Humans
- Animals
- Female
- Granuloma, Pyogenic / etiology
- Granuloma, Pyogenic / veterinary
- Granuloma, Pyogenic / pathology
- Corneal Diseases / etiology
- Corneal Diseases / therapy
- Corneal Diseases / veterinary
- Cornea / pathology
- Corneal Injuries / veterinary
- Corneal Injuries / pathology
- Corneal Ulcer / etiology
- Corneal Ulcer / therapy
- Corneal Ulcer / veterinary
- Wound Healing
- Horse Diseases / etiology
- Horse Diseases / therapy
- Horse Diseases / pathology
References
This article includes 19 references
- Lin RL, Janniger CK. Pyogenic granuloma.. Cutis 2004;74:229-233.
- Epivatianos A, Antoniades D, ZaraboukasT ZE, Poulopoulos A, Kiziridou A, Iordanidis S. Pyogenic granuloma of the oral cavity: comparative study of its clinicopathological and immunohistochemical features.. Pathol Int 2005;55:391-397.
- Giblin AV, Clover AJP, Athanassopoulos A, Budny PG. Pyogenic granuloma-the quest for optimum treatment: audit of treatment of 408 cases.. J Plast Reconstr Aesthet Surg 2007;60:1030-1035.
- Ferry APA. Pyogenic granuloma of the eye and ocular adnexa: a study of 100 cases.. Trans Am Ophthalmol Soc 1989;87:327-347.
- Papadopoulos M, Snibson GR, McKelvie PA. Pyogenic granuloma of the cornea.. Aust N Z J Ophthalmol 1998;26:185-188.
- Brooks DE, Matthew SA, Clode AB. Diseases of the cornea.. In: Gilger BC, ed. Equine Ophthalmology. 3rd ed. Ames; 2017:252-368.
- Googe JM, Mackman G, Peterson MR. Pyogenic granulomas of the cornea.. Surv Ophthalmol 1984;29:188-192.
- Cameron JA, Mahmood MA. Pyogenic granulomas of the cornea.. Ophthalmology 1995;102:1681-1687.
- Mietz H, Arnold G, Kirchhof B, Krieglstein GK. Pyogenic granuloma of the cornea: report of a case and review of the literature.. Graefes Arch Clin Exp Ophthalmol 1996;234:131-136.
- Minckler D. Pyogenic granuloma of the cornea simulating squamous cell carcinoma.. Arch Ophthalmol 1979;97:516-517.
- Srinivasan S, Prajna NV, Srinivasan M. Pyogenic granuloma of the cornea: a case report.. Indian J Ophthalmol 1996;44:39-40.
- Karatza E, Calhoun JH, Eagle RC. Pyogenic granuloma of the cornea in an infant with unilateral microphthalmia.. Arch Ophthalmol 2003;121:1197-1200.
- Aemero A, Sisay B. Corneal pyogenic granuloma: rare complication of infectious keratitis.. Ethiop J Health Sci 2014;24:85-88.
- de Potter P, Tardio DJ, Shields CL, Shields JA. Pyogenic granuloma of the cornea after penetrating keratoplasty.. Cornea 1992;11:589-591.
- Spencer WH. Ophthalmic Pathology. An Atlas and Textbook.. 3rd ed. Saunders; 1985:156-157.
- Plummer CE. Corneal response to injury and infection in horses.. Vet Clin North Am Equine Pract 2017;33:439-463.
- Rieger J, Kaessmeyer S, al Masri S, Hünigen H, Plendl J. Endothelial cells and angiogenesis in the horse in health and disease - a review.. Anat Histol Embryol 2020;49:656-678.
- Bragado R, Bello E, Requena L. Increased expression of vascular endothelial growth factor in pyogenic granulomas.. Acta Derm Venereol 1999;79:422-425.
- Ishida CE, Ramos-e-Silva M. Cryosurgery in oral lesions.. Int J Dermatol 1998;37:283-285.
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
