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Quantification of antigen-specific antibody concentrations in tracheal lavage fluid of horses with summer pasture-associated obstructive pulmonary disease.
Abstract: To determine whether horses with summer pasture-associated obstructive pulmonary disease (SPAOPD) have increased concentrations of antigen-specific IgG and IgE in tracheal lavage fluid, compared with values in clinically normal horses. Methods: 8 horses (6 females, 2 geldings; 6 Quarter Horses, 2 Appaloosas), 14 to 23 years old and with previous diagnosis of SPAOPD, served as the principal group; 8 horses (2 females, 6 geldings; 1 Quarter Horse, 7 Thoroughbreds), 6 to 9 years old, with no evidence of respiratory tract disease, served as the control group. Methods: Data were collected twice during a 1-year period: when all SPAOPD-affected horses were manifesting clinical signs of disease (July), and when all SPAOPD-affected horses appeared clinically normal (February). On each occasion, clinical evaluations were performed and blood and tracheal lavage fluid samples were collected. Transtracheal lavage supernatant was evaluated for mold antigen-specific IgG and IgE concentrations. Results: Median IgE relative antibody unit (RAU) values were significantly higher in control, compared with principal, horses. The SPAOPD-affected horses had increased concentrations of specific IgG for only 1 antigen, during winter sample collection. Conclusions: Antigen-specific IgG and IgE RAU values were not increased in SPAOPD-affected horses when these horses were manifesting clinical signs of disease.
Publication Date: 1997-12-24 PubMed ID: 9401689 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
- Antibodies
- Antigen
- Asthma
- Bronchoalveolar Lavage
- Chronic Obstructive Pulmonary Disease
- Clinical Pathology
- Clinical Signs
- Clinical Study
- Diagnosis
- Disease Diagnosis
- Disease Etiology
- Equine Diseases
- Equine Health
- Horses
- Immunoglobulin E
- Immunoglobulin G
- Recurrent Airway Obstruction
- Respiratory Disease
- Trachea
- Veterinary Medicine
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research investigates the concentrations of antigen-specific antibodies, IgG and IgE, in the tracheal fluid of horses with a condition called summer pasture-associated obstructive pulmonary disease (SPAOPD), in comparison with healthy, control horses. The results indicate that increased levels of these antibodies were not found in SPAOPD-affected horses during periods of disease manifestation.
Study Participants
- The research consisted of two groups of horses; one group constituted of horses diagnosed with SPAOPD (the principal group) and the other group made up of clinically healthy horses (control group).
- The principal group was comprised of eight horses, aged between 14 to 23 years, and they included six females and two geldings from Quarter Horse and Appaloosa breeds.
- The control group also consisted of eight horses, aged from 6 to 9 years, and included two females and six geldings mostly from the Thoroughbred breed, with one being a Quarter Horse.
Methodology
- Data were collected at two separate points during a year, specifically in July (when all SPAOPD-affected horses were manifesting symptoms) and in February (when all SPAOPD-affected horses appeared clinically normal).
- During each data collection phase, clinical evaluations were conducted, and blood and tracheal lavage fluid samples were collected from all participating horses.
- The collected tracheal lavage samples were analyzed for the concentrations of mold antigen-specific IgG and IgE antibodies.
Results
- The findings revealed that median IgE relative antibody unit (RAU) values were significantly higher in the control group compared to the principal (SPAOPD-affected) group.
- The SPAOPD-affected horses had increased concentrations of specific IgG for only one antigen, which was observed during the winter sample collection.
Conclusions
- It was concluded that the levels of antigen-specific IgG and IgE RAUs were not increased in SPAOPD-affected horses during periods when these horses were showing clinical signs of the disease.
- This suggests that increased concentrations of these antibodies may not be a reliable indicator or biomarker for exacerbations of SPAOPD.
Cite This Article
APA
Seahorn TL, Beadle RE, McGorum BC, Marley CL.
(1997).
Quantification of antigen-specific antibody concentrations in tracheal lavage fluid of horses with summer pasture-associated obstructive pulmonary disease.
Am J Vet Res, 58(12), 1408-1411.
Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
MeSH Terms
- Aging / blood
- Aging / immunology
- Animals
- Antibodies / analysis
- Antibodies / blood
- Antibodies / immunology
- Antibody Specificity
- Female
- Horse Diseases / blood
- Horse Diseases / immunology
- Horses
- Immunoglobulin E / analysis
- Immunoglobulin E / blood
- Immunoglobulin E / immunology
- Immunoglobulin G / analysis
- Immunoglobulin G / blood
- Immunoglobulin G / immunology
- Lung Diseases, Obstructive / blood
- Lung Diseases, Obstructive / immunology
- Lung Diseases, Obstructive / veterinary
- Male
- Seasons
- Therapeutic Irrigation / veterinary
- Trachea / immunology
- Urea / blood
Citations
This article has been cited 5 times.- Bright LA, Dittmar W, Nanduri B, McCarthy FM, Mujahid N, Costa LR, Burgess SC, Swiderski CE. Modeling the pasture-associated severe equine asthma bronchoalveolar lavage fluid proteome identifies molecular events mediating neutrophilic airway inflammation. Vet Med (Auckl) 2019;10:43-63.
- Venugopal CS, Holmes EP, Polikepahad S, Laborde S, Kearney M, Moore RM. Neurokinin receptors in recurrent airway obstruction: a comparative study of affected and unaffected horses. Can J Vet Res 2009 Jan;73(1):25-33.
- Polikepahad S, Haque M, Francis J, Moore RM, Venugopal CS. Characterization of endothelin receptors in the peripheral lung tissues of horses unaffected and affected with recurrent airway obstruction. Can J Vet Res 2008 Jul;72(4):340-9.
- Venugopal CS, Polikepahad S, Holmes EP, Heuvel JV, Leas TL, Moore RM. Endothelin receptor alterations in equine airway hyperreactivity. Can J Vet Res 2006 Jan;70(1):50-7.
- Venugopalan CS, Beadle RE, Seahorn TL, Holmes EP. Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. Vet Res Commun 1998 Nov;22(7):493-503.
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