Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis.
Abstract: Spinal neurosarcoidosis is a rare disease that can manifest as myelopathy, radiculopathy, or cauda equine syndrome. Spinal epidural lipomatosis is also a rare condition resulting from overgrowth of epidural fat tissue causing compressive myelopathy. To our knowledge, there are no reports linking epidural lipomatosis and spinal neurosarcoidosis. . We describe a case of progressive myelitis in the presence of concomitant spinal neurosarcoidosis and epidural lipomatosis which was a challenging diagnosis with complete response to treatment after addressing both diseases. Both etiologies are inflammatory in nature and share similar expression of inflammatory factors such as TNF- and IL-1. Conclusions: The common inflammatory process involved in these two diseases might explain a pathophysiological interconnection between both diseases that may underlie their concomitant development in our patient. If these two diseases are interconnected, in their pathophysiological mechanism remains a hypothesis that will need further investigation.
Copyright © 2021 Nesreen Jaafar et al.
Publication Date: 2021-01-28 PubMed ID: 33604089PubMed Central: PMC7869444DOI: 10.1155/2021/5952724Google Scholar: Lookup
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- Case Reports
Summary
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This study revolves around a unique case of a rare medical condition, where epidural lipomatosis and spinal neurosarcoidosis co-occur. The researchers explore how these two inflammatory diseases could be linked, hypothesizing that they might share a common pathophysiological connection.
Background of Study
- Spinal neurosarcoidosis is a rare disease that can present in various forms that include myelopathy, radiculopathy, or cauda equine syndrome.
- Another uncommon condition is spinal epidural lipomatosis where overgrowth of epidural fat tissue causes compressive myelopathy.
- To date, there have been no reports linking epidural lipomatosis and spinal neurosarcoidosis.
- Both of these diseases are inflammatory in nature and show similar expression of inflammatory factors, specifically Tumour Necrosis Factor (TNF) and Interleukin 1 (IL-1).
Case Study
- The researchers reported a unique case of progressive myelitis with coexistence of spinal neurosarcoidosis and epidural lipomatosis.
- This case was challenging to diagnose but exhibited a complete response to treatment when both conditions were addressed.
Conclusions and Further Implications
- The same inflammatory process involved in both of these diseases could be the cause of a pathophysiological interconnection, which may explain their simultaneous development in this patient.
- This suggests a potential link between these two diseases’ mechanisms, which could lead to further investigation and understanding of their natures.
This case study raises awareness of the possibility of coexistence between these two rare diseases and encourages further investigation into their potential common pathologies. Querying this link might enhance our understanding and thus improve diagnostic approach and treatment strategies.
Cite This Article
APA
Jaafar N, Khoueiry M, Khoury SJ, Makki A.
(2021).
Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis.
Case Rep Neurol Med, 2021, 5952724.
https://doi.org/10.1155/2021/5952724 Publication
Researcher Affiliations
- Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.
- Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.
- Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.
- Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.
Conflict of Interest Statement
The authors declare that they have no conflicts of interest.
References
This article includes 13 references
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Citations
This article has been cited 1 times.- Walker PB, Sark C, Brennan G, Smith T, Sherman WF, Kaye AD. Spinal Epidural Lipomatosis: A Comprehensive Review.. Orthop Rev (Pavia) 2021;13(2):25571.
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