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Clinical allergy1977; 7(5); 455-464; doi: 10.1111/j.1365-2222.1977.tb01476.x

RAST in the diagnosis of hypersensitivity to horse allergens. A comparison with clinical history and in vivo tests.

Abstract: Case history, skin tests and RAST were compared in a group (n = 40) of children with a history suggesting allergy to horses and in a group (n = 43) in whom there was no suspicion of hypersensitivity to horses. There was an agreement of 91% between case history and prick test. The same magnitude of agreement was found between case history and RAST (89%), and the agreement between RAST and prick test was 90%. The results of this investigation are clearly in contrast to earlier earlier reports, in that there was a very good correlation between prick test, RAST and case history. The results suggest that: (a) a proper evaluation of the skin test is of critical importance for the degree of correlation with other diagnostic tests; and (b) RAST is as reliable as carefully performed and evaluated skin tests.
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Publication Date: 1977-09-01 PubMed ID: 563309DOI: 10.1111/j.1365-2222.1977.tb01476.xGoogle Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study compares the effectiveness of Radioallergosorbent Test (RAST) with traditional clinical history and skin tests in diagnosing horse allergen hypersensitivity in children. The results indicate a high level of agreement among all three methods, suggesting the RAST is as reliable as the other methods.

Participants

  • The study involved two groups of children, each with distinctive backgrounds in relation to horse allergen hypersensitivity.
  • The first group consisted of 40 children with a history suggesting allergy to horses.
  • The second group originated from 43 children having no suspicion of hypersensitivity to horses.

Methods

  • The researchers employed three different tests to compute the prevalence of horse allergen hypersensitivity in the participants – case history, skin tests and RAST.
  • Case history involved checking the records of the children to understand the instances of their allergic reactions in the past.
  • Skin tests included pricking the skin of the participants to introduce a small amount of allergen and observing for any reaction.
  • The Radioallergosorbent Test (RAST), an in-vitro testing method, was used to measure the levels of allergen-specific antibodies in the blood samples of the children.

Findings

  • There was a 91% agreement between the case history and the skin test results, indicating both tests largely drew similar conclusions.
  • The correlation between case history and RAST results was noted to be 89%, reflecting a fairly high level of agreement.
  • A 90% agreement between RAST and prick tests was observed, suggesting that RAST is as reliable as skin tests in diagnosing horse allergen hypersensitivity.

Implications

  • The study results contradicted previous reports, and demonstrated a strong correlation between case history, skin tests, and RAST.
  • The high level of agreement among the three methods suggests that the accuracy of these diagnostic tests is strongly influenced by their careful performance and evaluation.
  • Also, the findings indicate that RAST could be employed as a reliable method for diagnosing horse allergen hypersensitivity.

Cite This Article

APA
Leegaard J, Roth A. (1977). RAST in the diagnosis of hypersensitivity to horse allergens. A comparison with clinical history and in vivo tests. Clin Allergy, 7(5), 455-464. https://doi.org/10.1111/j.1365-2222.1977.tb01476.x

Publication

Clinical allergy
ISSN: 0009-9090
NlmUniqueID: 0311172
Country: England
Language: English
Volume: 7
Issue: 5
Pages: 455-464

Researcher Affiliations

Leegaard, J
    Roth, A

      MeSH Terms

      • Adolescent
      • Adult
      • Allergens
      • Animals
      • Child
      • Child, Preschool
      • Female
      • Hair / immunology
      • Horses / immunology
      • Humans
      • Hypersensitivity / diagnosis
      • Immunoglobulin E / analysis
      • Male
      • Radioallergosorbent Test
      • Radioimmunoassay
      • Serum Albumin / immunology
      • Skin Tests

      Citations

      This article has been cited 3 times.
      1. Cookson JB, Makoni G. Prevalence of asthma in Rhodesian Africans. Thorax 1980 Nov;35(11):833-7.
        doi: 10.1136/thx.35.11.833pubmed: 7221979google scholar: lookup
      2. Ohman JL Jr, Sundin B. Standardized allergenic extracts derived from mammals. Clin Rev Allergy 1987 Feb;5(1):37-47.
        doi: 10.1007/BF02802256pubmed: 3548938google scholar: lookup
      3. Johansson SG, Yman L. In vitro assays for immunoglobulin E. Methodology, indications, and interpretation. Clin Rev Allergy 1988 Summer;6(2):93-139.
        doi: 10.1007/BF02914935pubmed: 3048627google scholar: lookup
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