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Home / Equine Research Bank / Equine Vet J / Recurrent airway obstruction: a review.
Equine veterinary journal2014; 46(3); 276-288; doi: 10.1111/evj.12204

Recurrent airway obstruction: a review.

Abstract: Recurrent airway obstruction is a widely recognised airway disorder, characterised by hypersensitivity-mediated neutrophilic airway inflammation and lower airway obstruction in a subpopulation of horses when exposed to suboptimal environments high in airborne organic dust. Over the past decade, numerous studies have further advanced our understanding of different aspects of the disease. These include clarification of the important inhaled airborne agents responsible for disease induction, improving our understanding of the underlying genetic basis of disease susceptibility and unveiling the fundamental immunological mechanisms leading to establishment of the classic disease phenotype. This review, as well as giving a clinical overview of recurrent airway obstruction, summarises much of the work in these areas that have culminated in a more thorough understanding of this debilitating disease.
© 2013 EVJ Ltd.
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Publication Date: 2014-01-07 PubMed ID: 24164473DOI: 10.1111/evj.12204Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is a review of recurrent airway obstruction (RAO), a common airway disorder in horses. It provides insights into various aspects of the disease with a particular emphasis on disease induction, genetic susceptibility, and immune mechanisms.

Overview of Recurrent Airway Obstruction (RAO)

  • RAO is a well-known airway disorder affecting horses. The disease manifests through an inflammation of the airways and their consequent obstruction, caused by heightened sensitivity to airborne organic dust prevalent in less-than-ideal living conditions for the animals.
  • This comprehensive review endeavours to highlight the insights gained over the past decade from numerous studies about this condition. The main areas of focus are the agents responsible for triggering the disease, the genetic factors that make some horses more susceptible to the condition, and the immune system processes that contribute to the disease’s progression.

Airborne Agents and RAO Induction

  • The paper explains the role that inhaled airborne agents play in RAO, emphasising that certain constituents of airborne organic dust can initiate the disease.
  • Overexposure to these harmful elements can trigger an immunological response in the susceptible horses, leading to the inflammation and obstruction of airways characteristic of RAO.

Genetic Susceptibility to RAO

  • This review delves into the genetic basis of susceptibility to the disease. The understanding is that not all horses are equally prone to RAO, an indicator of inherent genetic variance playing a role.
  • The researchers review studies exploring various genetic markers linked to heightened vulnerability to RAO, adding depth to our grasp of the disease’s genetic component.

Immunological Mechanisms in RAO

  • The article further reveals the relationship between RAO and the immune system. When exposed to the disease-causing agents, an immunological response is set off that results in the known symptoms of the disease.
  • According to the review, understanding these immune trigger systems and responses is key to comprehending the debilitating health impacts of RAO on afflicted horses. Such knowledge can guide the development of more effective treatment modalities and therapies for affected horses.

Understanding RAO for Better Management

  • This review amasses a significant body of research on RAO, aiming to deepen our understanding of the disease. Through studying the causative agents, genetic susceptibility, and immunological responses in the disease, it illuminates the complex mechanisms underpinning RAO.
  • The ultimate goal is to leverage this enriched understanding to better manage and even prevent RAO in horses, thereby improving their health and life quality.

Cite This Article

APA
Pirie RS. (2014). Recurrent airway obstruction: a review. Equine Vet J, 46(3), 276-288. https://doi.org/10.1111/evj.12204

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 46
Issue: 3
Pages: 276-288

Researcher Affiliations

Pirie, R S
  • Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Roslin, Midlothian, UK.

MeSH Terms

  • Animals
  • Genetic Predisposition to Disease
  • Horse Diseases / genetics
  • Horse Diseases / pathology
  • Horses
  • Pulmonary Disease, Chronic Obstructive / genetics
  • Pulmonary Disease, Chronic Obstructive / pathology
  • Pulmonary Disease, Chronic Obstructive / veterinary

Citations

This article has been cited 52 times.
  1. Woodrow JS, Sheats MK, Cooper B, Bayless R. Asthma: The Use of Animal Models and Their Translational Utility. Cells 2023 Apr 5;12(7).
    doi: 10.3390/cells12071091pubmed: 37048164google scholar: lookup
  2. Woodrow JS, Hines M, Sommardahl C, Flatland B, Lo Y, Wang Z, Sheats MK, Lennon EM. Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma. Front Vet Sci 2022;9:997139.
    doi: 10.3389/fvets.2022.997139pubmed: 36713876google scholar: lookup
  3. Klier J, Fuchs S, Winter G, Gehlen H. Inhalative Nanoparticulate CpG Immunotherapy in Severe Equine Asthma: An Innovative Therapeutic Concept and Potential Animal Model for Human Asthma Treatment. Animals (Basel) 2022 Aug 16;12(16).
    doi: 10.3390/ani12162087pubmed: 36009677google scholar: lookup
  4. Calzetta L, Pistocchini E, Ritondo BL, Cavalli F, Camardelli F, Rogliani P. Muscarinic receptor antagonists and airway inflammation: A systematic review on pharmacological models. Heliyon 2022 Jun;8(6):e09760.
    doi: 10.1016/j.heliyon.2022.e09760pubmed: 35785239google scholar: lookup
  5. Mahalingam-Dhingra A, Mazan MR, Bedenice D, Ceresia M, Minuto J, Deveney EF. A CONSORT-guided, randomized, double-blind, controlled pilot clinical trial of inhaled lidocaine for the treatment of equine asthma. Can J Vet Res 2022 Apr;86(2):116-124.
    pubmed: 35388235
  6. Lee GKC, Beeler-Marfisi J, Viel L, Piché É, Kang H, Sears W, Bienzle D. Bronchial brush cytology, endobronchial biopsy, and SALSA immunohistochemistry in severe equine asthma. Vet Pathol 2022 Jan;59(1):100-111.
    doi: 10.1177/03009858211048635pubmed: 34903109google scholar: lookup
  7. Lo Feudo CM, Stucchi L, Alberti E, Stancari G, Conturba B, Zucca E, Ferrucci F. The Role of Thoracic Ultrasonography and Airway Endoscopy in the Diagnosis of Equine Asthma and Exercise-Induced Pulmonary Hemorrhage. Vet Sci 2021 Nov 15;8(11).
    doi: 10.3390/vetsci8110276pubmed: 34822649google scholar: lookup
  8. Kang H, Bienzle D, Lee GKC, Piché É, Viel L, Odemuyiwa SO, Beeler-Marfisi J. Flow cytometric analysis of equine bronchoalveolar lavage fluid cells in horses with and without severe equine asthma. Vet Pathol 2022 Jan;59(1):91-99.
    doi: 10.1177/03009858211042588pubmed: 34521286google scholar: lookup
  9. Lo Feudo CM, Stucchi L, Alberti E, Conturba B, Zucca E, Ferrucci F. Intradermal Testing Results in Horses Affected by Mild-Moderate and Severe Equine Asthma. Animals (Basel) 2021 Jul 13;11(7).
    doi: 10.3390/ani11072086pubmed: 34359214google scholar: lookup
  10. Morini M, Peli A, Rinnovati R, Magazzù G, Romagnoli N, Spadari A, Pietra M. Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase. Animals (Basel) 2021 May 12;11(5).
    doi: 10.3390/ani11051376pubmed: 34066204google scholar: lookup
  11. Millares-Ramirez EM, Lavoie JP. Bronchial angiogenesis in horses with severe asthma and its response to corticosteroids. J Vet Intern Med 2021 Jul;35(4):2026-2034.
    doi: 10.1111/jvim.16159pubmed: 34048095google scholar: lookup
  12. Slowikowska M, Bajzert J, Miller J, Stefaniak T, Niedzwiedz A. The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma. Animals (Basel) 2021 Apr 2;11(4).
    doi: 10.3390/ani11041001pubmed: 33918401google scholar: lookup
  13. de Wasseige S, Picotte K, Lavoie JP. Nebulized dexamethasone sodium phosphate in the treatment of horses with severe asthma. J Vet Intern Med 2021 May;35(3):1604-1611.
    doi: 10.1111/jvim.16113pubmed: 33817859google scholar: lookup
  14. Pirie RS, Mueller HW, Engel O, Albrecht B, von Salis-Soglio M. Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial. Equine Vet J 2021 Nov;53(6):1094-1104.
    doi: 10.1111/evj.13419pubmed: 33403727google scholar: lookup
  15. Hulliger MF, Pacholewska A, Vargas A, Lavoie JP, Leeb T, Gerber V, Jagannathan V. An Integrative miRNA-mRNA Expression Analysis Reveals Striking Transcriptomic Similarities between Severe Equine Asthma and Specific Asthma Endotypes in Humans. Genes (Basel) 2020 Sep 28;11(10).
    doi: 10.3390/genes11101143pubmed: 32998415google scholar: lookup
  16. Löfgren M, Larsson P, Lindberg R, Hörnaeus K, Tydén E. Expression of xenobiotic metabolising enzymes in lungs of horses with or without histological evidence of lower airway inflammation. Vet Med Sci 2021 Jan;7(1):16-24.
    doi: 10.1002/vms3.331pubmed: 32791560google scholar: lookup
  17. Hue E, Orard M, Toquet MP, Depecker M, Couroucé A, Pronost S, Paillot R, Richard EA. Asymmetrical Pulmonary Cytokine Profiles Are Linked to Bronchoalveolar Lavage Fluid Cytology of Horses With Mild Airway Neutrophilia. Front Vet Sci 2020;7:226.
    doi: 10.3389/fvets.2020.00226pubmed: 32391392google scholar: lookup
  18. Wilson ME, McCandless EE, Olszewski MA, Robinson NE. Alveolar macrophage phenotypes in severe equine asthma. Vet J 2020 Feb;256:105436.
    doi: 10.1016/j.tvjl.2020.105436pubmed: 32113585google scholar: lookup
  19. MacDonald ES, Barrett JG. The Potential of Mesenchymal Stem Cells to Treat Systemic Inflammation in Horses. Front Vet Sci 2019;6:507.
    doi: 10.3389/fvets.2019.00507pubmed: 32039250google scholar: lookup
  20. White SJ, Moore-Colyer M, Marti E, Hannant D, Gerber V, Coüetil L, Richard EA, Alcocer M. Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Sci Rep 2019 Oct 23;9(1):15170.
    doi: 10.1038/s41598-019-51820-7pubmed: 31645629google scholar: lookup
  21. Sheats MK, Davis KU, Poole JA. Comparative Review of Asthma in Farmers and Horses. Curr Allergy Asthma Rep 2019 Oct 10;19(11):50.
    doi: 10.1007/s11882-019-0882-2pubmed: 31599358google scholar: lookup
  22. Raudsepp T, Finno CJ, Bellone RR, Petersen JL. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. Anim Genet 2019 Dec;50(6):569-597.
    doi: 10.1111/age.12857pubmed: 31568563google scholar: lookup
  23. White S, Moore-Colyer M, Marti E, Coüetil L, Hannant D, Richard EA, Alcocer M. Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma. J Vet Intern Med 2019 Sep;33(5):2327-2335.
    doi: 10.1111/jvim.15564pubmed: 31429513google scholar: lookup
  24. Barton AK, Shety T, Klier J, Geis S, Einspanier R, Gehlen H. Metalloproteinases and their Inhibitors under the Course of Immunostimulation by CPG-ODN and Specific Antigen Inhalation in Equine Asthma. Mediators Inflamm 2019;2019:7845623.
    doi: 10.1155/2019/7845623pubmed: 31316303google scholar: lookup
  25. Verdon M, Lanz S, Rhyner C, Gerber V, Marti E. Allergen-specific immunoglobulin E in sera of horses affected with insect bite hypersensitivity, severe equine asthma or both conditions. J Vet Intern Med 2019 Jan;33(1):266-274.
    doi: 10.1111/jvim.15355pubmed: 30520523google scholar: lookup
  26. Orard M, Hue E, Couroucé A, Bizon-Mercier C, Toquet MP, Moore-Colyer M, Couëtil L, Pronost S, Paillot R, Demoor M, Richard EA. The influence of hay steaming on clinical signs and airway immune response in severe asthmatic horses. BMC Vet Res 2018 Nov 15;14(1):345.
    doi: 10.1186/s12917-018-1636-4pubmed: 30442129google scholar: lookup
  27. Tessier L, Côté O, Clark ME, Viel L, Diaz-Méndez A, Anders S, Bienzle D. Gene set enrichment analysis of the bronchial epithelium implicates contribution of cell cycle and tissue repair processes in equine asthma. Sci Rep 2018 Nov 6;8(1):16408.
    doi: 10.1038/s41598-018-34636-9pubmed: 30401798google scholar: lookup
  28. Tessier L, Côté O, Bienzle D. Sequence variant analysis of RNA sequences in severe equine asthma. PeerJ 2018;6:e5759.
    doi: 10.7717/peerj.5759pubmed: 30324028google scholar: lookup
  29. Bond S, Léguillette R, Richard EA, Couetil L, Lavoie JP, Martin JG, Pirie RS. Equine asthma: Integrative biologic relevance of a recently proposed nomenclature. J Vet Intern Med 2018 Nov;32(6):2088-2098.
    doi: 10.1111/jvim.15302pubmed: 30294851google scholar: lookup
  30. Mainguy-Seers S, Picotte K, Lavoie JP. Efficacy of tamoxifen for the treatment of severe equine asthma. J Vet Intern Med 2018 Sep;32(5):1748-1753.
    doi: 10.1111/jvim.15289pubmed: 30084157google scholar: lookup
  31. Mason VC, Schaefer RJ, McCue ME, Leeb T, Gerber V. eQTL discovery and their association with severe equine asthma in European Warmblood horses. BMC Genomics 2018 Aug 2;19(1):581.
    doi: 10.1186/s12864-018-4938-9pubmed: 30071827google scholar: lookup
  32. Husulak ML, Manning ST, Meachem MD, Burgess HJ, Epp TY, Montgomery JB. Does antimicrobial therapy improve outcomes in horses with severe equine asthma and a positive tracheal wash bacterial culture?. Can J Vet Res 2018 Jul;82(3):184-191.
    pubmed: 30026642
  33. Siegers EW, Anthonisse M, van Eerdenburg FJCM, van den Broek J, Wouters IM, Westermann CM. Effect of ionization, bedding, and feeding on air quality in a horse stable. J Vet Intern Med 2018 May;32(3):1234-1240.
    doi: 10.1111/jvim.15069pubmed: 29485234google scholar: lookup
  34. Tessier L, Côté O, Clark ME, Viel L, Diaz-Méndez A, Anders S, Bienzle D. Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma. BMC Genomics 2017 Sep 8;18(1):708.
    doi: 10.1186/s12864-017-4107-6pubmed: 28886691google scholar: lookup
  35. Henríquez C, Morán G, Carrasco C, Sarmiento J, Barría M, Folch H, Uberti B. Modulatory role of regulatory T cells in a murine model of severe equine asthma. BMC Vet Res 2017 Apr 28;13(1):117.
    doi: 10.1186/s12917-017-1037-0pubmed: 28454585google scholar: lookup
  36. Barton AK, Gehlen H. Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse?. Mediators Inflamm 2016;2016:5693205.
    doi: 10.1155/2016/5693205pubmed: 28053371google scholar: lookup
  37. Barton AK, Pelli A, Rieger M, Gehlen H. Procalcitonin as a biomarker in equine chronic pneumopathies. BMC Vet Res 2016 Dec 9;12(1):281.
    doi: 10.1186/s12917-016-0912-4pubmed: 27938364google scholar: lookup
  38. Barton AK, Shety T, Bondzio A, Einspanier R, Gehlen H. Metalloproteinases and their inhibitors are influenced by inhalative glucocorticoid therapy in combination with environmental dust reduction in equine recurrent airway obstruction. BMC Vet Res 2016 Dec 9;12(1):282.
    doi: 10.1186/s12917-016-0915-1pubmed: 27938355google scholar: lookup
  39. Rütten S, Schusser GF, Abraham G, Schrödl W. Release kinetics of tumor necrosis factor-α and interleukin-1 receptor antagonist in the equine whole blood. BMC Vet Res 2016 Jun 17;12(1):117.
    doi: 10.1186/s12917-016-0742-4pubmed: 27316332google scholar: lookup
  40. Sandersen C, Bienzle D, Cerri S, Franck T, Derochette S, Neven P, Mouytis-Mickalad A, Serteyn D. Effect of inhaled hydrosoluble curcumin on inflammatory markers in broncho-alveolar lavage fluid of horses with LPS-induced lung neutrophilia. Multidiscip Respir Med 2015;10(1):16.
    doi: 10.1186/s40248-015-0010-7pubmed: 25908974google scholar: lookup
  41. Jensen-Jarolim E, Einhorn L, Herrmann I, Thalhammer JG, Panakova L. Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities. Clin Transl Allergy 2015;5:15.
    doi: 10.1186/s13601-015-0059-6pubmed: 25852853google scholar: lookup
  42. Richard EA, Depecker M, Defontis M, Leleu C, Fortier G, Pitel PH, Couroucé-Malblanc A. Cytokine concentrations in bronchoalveolar lavage fluid from horses with neutrophilic inflammatory airway disease. J Vet Intern Med 2014 Nov-Dec;28(6):1838-44.
    doi: 10.1111/jvim.12464pubmed: 25269933google scholar: lookup
  43. Cooper BL, Hobbs KJ, Bayless R, Stinson-Miller A, Gruber E, Hepworth-Warren K, Lavoie JP, Sheats MK. A Portable Fluorometer Detects Significantly Elevated Cell-Free DNA in Tracheal Wash and Bronchoalveolar Lavage Fluid in Horses with Severe Asthma. Animals (Basel) 2025 Dec 3;15(23).
    doi: 10.3390/ani15233483pubmed: 41375541google scholar: lookup
  44. Lendl L, Wirth C, Merle R, Barton AK. Influence of a Standardized Lunging Exercise Test on BALF Cytology in Horses Suffering from Mild-Moderate Equine Asthma. Animals (Basel) 2025 Aug 19;15(16).
    doi: 10.3390/ani15162428pubmed: 40867756google scholar: lookup
  45. Lendl L, Barton AK. Equine Asthma Diagnostics: Review of Influencing Factors and Difficulties in Diagnosing Subclinical Disease. Animals (Basel) 2024 Dec 4;14(23).
    doi: 10.3390/ani14233504pubmed: 39682469google scholar: lookup
  46. Mańkowska A, Witkowska D. The Most Common Environmental Risk Factors for Equine Asthma-A Narrative Review. Animals (Basel) 2024 Jul 14;14(14).
    doi: 10.3390/ani14142062pubmed: 39061524google scholar: lookup
  47. Diez de Castro E, Fernandez-Molina JM. Environmental Management of Equine Asthma. Animals (Basel) 2024 Jan 30;14(3).
    doi: 10.3390/ani14030446pubmed: 38338089google scholar: lookup
  48. Simões J, Tilley P. Decision Making in Severe Equine Asthma-Diagnosis and Monitoring. Animals (Basel) 2023 Dec 16;13(24).
    doi: 10.3390/ani13243872pubmed: 38136909google scholar: lookup
  49. Hartung BF, Mueller RS, Gauss J, Weitzer T, Boehm TMSA, Palić J, Schulz B. Reactions to environmental allergens in cats with feline lower airway disease. Front Vet Sci 2023;10:1267496.
    doi: 10.3389/fvets.2023.1267496pubmed: 38130436google scholar: lookup
  50. White SJ, Couetil L, Richard EA, Marti E, Wilson PB. Microarray molecular mapping of horses with severe asthma. J Vet Intern Med 2024 Jan-Feb;38(1):477-484.
    doi: 10.1111/jvim.16951pubmed: 38071496google scholar: lookup
  51. Mönki J, Holopainen M, Ruhanen H, Karikoski N, Käkelä R, Mykkänen A. Lipid species profiling of bronchoalveolar lavage fluid cells of horses housed on two different bedding materials. Sci Rep 2023 Dec 8;13(1):21778.
    doi: 10.1038/s41598-023-49032-1pubmed: 38066223google scholar: lookup
  52. Westerfeld R, Payette F, Dubuc V, Manguin E, Picotte K, Beauchamp G, Bédard C, Leclere M. Effects of soaked hay on lung function and airway inflammation in horses with severe asthma. J Vet Intern Med 2024 Jan-Feb;38(1):469-476.
    doi: 10.1111/jvim.16919pubmed: 37930110google scholar: lookup
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