Refinement of quantitative trait loci on equine chromosome 10 for radiological signs of navicular disease in Hanoverian warmblood horses.
Abstract: Navicular disease is characterized by a progressive degenerative alteration of the equine podotrochlea. In this study, we refined a previously identified quantitative trait locus (QTL) on horse chromosome 10 for the abnormal development of canales sesamoidales (DCS) of the navicular bone in Hanoverian warmblood horses. Genotyping was done in 192 Hanoverian warmblood horses from 17 paternal half-sib groups. The whole marker set comprised 45 markers including seven newly developed microsatellites and 13 single nucleotide polymorphisms (SNPs) within positional candidate genes. Chromosome-wide significant QTL were confirmed and refined for DCS on horse chromosome (ECA) 10 at 0.16-2.70 Mb and at 14.45-36.37 Mb. Nine microsatellites and three SNP markers reached the highest multipoint Zmeans and LOD scores at 19.34-20.38 Mb and at 23.17-30.73 Mb with genome-wide error probabilities of P<0.05. In addition, a significant association of a SNP within VSTM1 and a significant haplotype-trait association within IRF3 could be shown. These results support a possible role of the candidate genes VSTM1 and IRF3 within the QTL on ECA10 for DCS. This study is a further step towards the identification of the genes responsible for navicular disease in Hanoverian warmblood horses.
© 2010 The Authors, Journal compilation © 2010 Stichting International Foundation for Animal Genetics.
Publication Date: 2010-11-26 PubMed ID: 21070274DOI: 10.1111/j.1365-2052.2010.02096.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research highlights the refinement of a previously identified genetic region in Hanoverian warmblood horses related to navicular disease. The study used advanced genotyping technology to better delineate the genetic factors contributing to this equine health issue.
About Navicular Disease
- Navicular disease affects horses and manifests as a progressive degenerative condition of the podotrochlea, a key structure in the horse’s hoof.
- This disease is often marked by the abnormal development of the canales sesamoidales (DCS), a part of the navicular bone found within the hoof structure.
Understanding the Quantitative Trait Locus (QTL)
- Earlier research had identified a QTL on equine chromosome 10 (ECA10) linked with the development of navicular disease in horses, particularly the abnormal development of DCS.
- A QTL is a section of the genome (an organism’s complete set of DNA) associated with a particular trait, such as disease susceptibility. In this case, the trait is the susceptibility or predisposition to develop navicular disease.
Refinement of the QTL and Genotyping
- The current study focused on refining this QTL using advanced genotyping technology in a sample of 192 Hanoverian warmblood horses from 17 paternal half-sibling groups.
- The researchers surveyed 45 markers, including newly developed microsatellites and single nucleotide polymorphisms (SNPs) within candidate genes located in this chromosome region.
- These markers are variations in the DNA sequence and can be used to identify specific genetic regions contributing to disease susceptibility.
Significant Findings and Candidate Genes
- The study confirmed and refined the QTL involved in DCS on ECA10 at two specific ranges: 0.16-2.70 Mb and 14.45-36.37 Mb.
- A particular SNP within the VSTM1 gene and a significant haplotype-trait association within the IRF3 gene were found to be significantly associated with the trait.
- These findings suggest a potential role of these two genes in the susceptibility to navicular disease in Hanoverian warmblood horses.
Impact of the Study
- This study is an advancement towards identifying the genes responsible for navicular disease, which could have implications for improved diagnosis, selection practices and potential therapeutic targets in the future.
Cite This Article
APA
Lopes MS, Diesterbeck U, Machado Ada C, Distl O.
(2010).
Refinement of quantitative trait loci on equine chromosome 10 for radiological signs of navicular disease in Hanoverian warmblood horses.
Anim Genet, 41 Suppl 2, 36-40.
https://doi.org/10.1111/j.1365-2052.2010.02096.x Publication
Researcher Affiliations
- Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany.
MeSH Terms
- Animals
- Bone Diseases / genetics
- Bone Diseases / pathology
- Bone Diseases / veterinary
- Chromosomes, Mammalian
- Female
- Foot Diseases / genetics
- Foot Diseases / pathology
- Foot Diseases / veterinary
- Horse Diseases / genetics
- Horse Diseases / pathology
- Horses / genetics
- Male
- Microsatellite Repeats
- Pedigree
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
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