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Tissue engineering and regenerative medicine2023; 20(6); 839-877; doi: 10.1007/s13770-023-00559-4

Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models.

Abstract: Peripheral nerve damage mainly resulted from traumatic or infectious causes; the main signs of a damaged nerve are the loss of sensory and/or motor functions. The injured nerve has limited regenerative capacity and is recovered by the body itself, the recovery process depends on the severity of damage to the nerve, nowadays the use of stem cells is one of the new and advanced methods for treatment of these problems. Following our review, data are collected from different databases "Google scholar, Springer, Elsevier, Egyptian Knowledge Bank, and PubMed" using different keywords such as Peripheral nerve damage, Radial Nerve, Sciatic Nerve, Animals, Nerve regeneration, and Stem cell to investigate the different methods taken in consideration for regeneration of PNI. This review contains tables illustrating all forms and types of regenerative medicine used in treatment of peripheral nerve injuries (PNI) including different types of stem cells " adipose-derived stem cells, bone marrow stem cells, Human umbilical cord stem cells, embryonic stem cells" and their effect on re-constitution and functional recovery of the damaged nerve which evaluated by physical, histological, Immuno-histochemical, biochemical evaluation, and the review illuminated the best regenerative strategies help in rapid peripheral nerve regeneration in different animal models included horse, dog, cat, sheep, monkey, pig, mice and rat. Old surgical attempts such as neurorrhaphy, autogenic nerve transplantation, and Schwann cell implantation have a limited power of recovery in cases of large nerve defects. Stem cell therapy including mesenchymal stromal cells has a high potential differentiation capacity to renew and form a new nerve and also restore its function.
© 2023. The Author(s).
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Publication Date: 2023-08-12 PubMed ID: 37572269PubMed Central: PMC10519924DOI: 10.1007/s13770-023-00559-4Google Scholar: Lookup
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  • Journal Article
  • Review
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research review explores different regenerative strategies for treating damaged peripheral nerves using stem cells and evaluates their effectiveness in various animal models.

Research Methodology

The authors conducted an extensive review of several databases to gather relevant research data. The databases included Google Scholar, Springer, Elsevier, Egyptian Knowledge Bank, and PubMed. The keywords used for the search included terms related to peripheral nerve damage, such as Radial Nerve, Sciatic Nerve, Animals, Nerve regeneration, and Stem cell.

  • The goal was to examine the various methods considered for the regeneration of Peripheral Nerve Injuries (PNI).

Findings from the Review

The review presented several tables that demonstrated various forms of regenerative medicine used in the treatment of PNI. Notably, different types of stem cells: adipose-derived stem cells, bone marrow stem cells, Human umbilical cord stem cells, and embryonic stem cells were found to be particularly effective in the healing process of damaged nerves.

  • These stem cells contributed to the reconstitution and functional recovery of the damaged nerve which was evaluated using physical, histological, Immuno-histochemical, and biochemical evaluations.
  • The study shone light on the best regenerative strategies that assist in rapid peripheral nerve regeneration in different animal models such as horses, dogs, cats, sheep, monkeys, pigs, mice, and rats.

Conclusions from the Research

Traditional surgical methods such as neurorrhaphy, autogenic nerve transplantation, and Schwann cell implantation have limits in their power of recovery, especially in cases of large nerve defects. However, stem cell therapy, particularly those using mesenchymal stromal cells, have shown to have a high potential for differentiation, providing an opportunity to renew and form new nerves and restore their function.

  • Stem cell therapy offers a promising alternative for the treatment of peripheral nerve injuries, going beyond the limitations of old surgical attempts.

Cite This Article

APA
Khaled MM, Ibrahium AM, Abdelgalil AI, El-Saied MA, El-Bably SH. (2023). Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models. Tissue Eng Regen Med, 20(6), 839-877. https://doi.org/10.1007/s13770-023-00559-4

Publication

Tissue engineering and regenerative medicine
ISSN: 2212-5469
NlmUniqueID: 101699923
Country: Korea (South)
Language: English
Volume: 20
Issue: 6
Pages: 839-877

Researcher Affiliations

Khaled, Mona M
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza Square, Giza, 12211, Egypt. mona.mohamed@vet.cu.edu.eg.
Ibrahium, Asmaa M
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza Square, Giza, 12211, Egypt.
Abdelgalil, Ahmed I
  • Department of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza Square, Giza, 12211, Egypt.
El-Saied, Mohamed A
  • Department of Pathology, Faculty of Veterinary of Veterinary Medicine, Cairo University, Giza Square, Giza, 12211, Egypt.
El-Bably, Samah H
  • Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza Square, Giza, 12211, Egypt.

MeSH Terms

  • Rats
  • Mice
  • Humans
  • Animals
  • Dogs
  • Horses
  • Sheep
  • Swine
  • Peripheral Nerve Injuries / therapy
  • Peripheral Nerve Injuries / pathology
  • Mesenchymal Stem Cell Transplantation / methods
  • Sciatic Nerve / injuries
  • Schwann Cells / pathology
  • Nerve Regeneration / physiology
  • Models, Animal

Conflict of Interest Statement

There are no conflicts of interest to declare.

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