[Regenerative therapy for tendon and ligament disorders in horses. Terminology, production, biologic potential and in vitro effects].
Abstract: Conventional treatments of equine tendon injuries lead to an unsatisfactory healing process that usually results in a relatively high recurrence rate. Therefore, in recent years so-called regenerative therapeutics were studied scientifically in vitro and in laboratory animals. These include substances that ideally lead to the formation of replacement tissue, which in contrast to the low quality scar, has similar functional properties as the original intact tendon. Currently, a plethora of different substrates is either commercially available or can be produced in practice with the help of kits. The current knowledge on the production and the regenerative potential of nucleated cells like stem cells from bone marrow and fat tissue, of the blood products PRP (platelet rich plasma), ACP (autologous conditioned plasma), ACS (autologous conditioned serum) and of the scaffold substance UBM (urinary bladder matrix) are presented. Finally, the potential of some growth factors and of gene therapy is considered. Currently, it is assumed that the regeneration of tendon tissue is promoted by a complex interaction of scaffolds, growth factors and cells. At present, only very few studies are available which allow a comparison between these substances. Studies on the effect of regenerative substrates on tendons in live horses are presented elsewhere.
Publication Date: 2011-12-15 PubMed ID: 22167082
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Summary
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The research article discusses the potential of regenerative therapy in treating tendon and ligament disorders in horses. It emphasizes the shortcomings of conventional treatments and introduces the study of substances useful in creating replacement tissue similar to the original intact tendon.
Conventional Treatments and their Shortcomings
- The paper begins by highlighting the limitations of conventional treatments for equine tendon injuries. These methods often lead to subpar healing processes with high recurrence rates of the injury.
Exploration of Regenerative Therapeutics
- In response to the drawbacks of conventional treatments, there has been an increased focus on regenerative therapeutics. This involves studying substances that can ideally form replacement tissue which, unlike low-quality scar tissue, can mirror the functional properties of the original tendon.
- Several substrates are currently available commercially or can be produced in practice using kits.
Regenerative Potential of Nucleated Cells and Blood Products
- The paper presents current knowledge on the productive and regenerative capabilities of nucleated cells such as stem cells derived from bone marrow and fat tissue.
- Various blood products like platelet-rich plasma (PRP), autologous conditioned plasma (ACP), and autologous conditioned serum (ACS) are discussed.
- The use of the scaffold substance urinary bladder matrix (UBM) is also mentioned.
Growth Factors and Gene Therapy
- The potential of various growth factors and gene therapy in promoting the regeneration of tendon tissue is examined.
- It is hypothesized that the regeneration of tendon tissue is facilitated by a complex interplay of scaffolds, growth factors, and cells.
Lack of Comparative Studies
- Despite the increasing interest in regenerative therapeutics, there are limited studies available that allow for a comparison of the effectiveness of different substances.
Studies on Live Horses
- The paper concludes by stating that studies examining the effect of regenerative substrates on tendons in live horses can be found elsewhere, indicating that this research is part of a larger body of work investigating this novel therapeutic approach.
Cite This Article
APA
Geburek F, Stadler P.
(2011).
[Regenerative therapy for tendon and ligament disorders in horses. Terminology, production, biologic potential and in vitro effects].
Tierarztl Prax Ausg G Grosstiere Nutztiere, 39(6), 373-383.
Publication
Researcher Affiliations
- Fachtierarzt für Pferde, Stiftung Tierärztliche Hochschule Hannover, Klinik für Pferde, Bünteweg 9, 30559 Hannover. Florian.Geburek@tiho-hannover.de
MeSH Terms
- Animals
- Blood Transfusion, Autologous / veterinary
- Bone Marrow Cells / physiology
- Genetic Therapy / veterinary
- Guided Tissue Regeneration / veterinary
- Horse Diseases / therapy
- Horses
- Intercellular Signaling Peptides and Proteins / therapeutic use
- Ligaments / physiology
- Platelet-Rich Plasma / physiology
- Regeneration
- Regenerative Medicine / methods
- Stem Cells / physiology
- Tendon Injuries / therapy
- Tendon Injuries / veterinary
- Tendons / physiology
- Tissue Scaffolds / veterinary
Citations
This article has been cited 7 times.- Zielińska P, Soroko M, Godlewska M, Śniegucka K, Dudek K, Howell K. Photothermal Effects of High-Intensity Laser Therapy on the Superficial Digital Flexor Tendon Area in Clinically Healthy Racehorses. Animals (Basel) 2022 May 12;12(10).
- Geburek F, Roggel F, van Schie HTM, Beineke A, Estrada R, Weber K, Hellige M, Rohn K, Jagodzinski M, Welke B, Hurschler C, Conrad S, Skutella T, van de Lest C, van Weeren R, Stadler PM. Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial. Stem Cell Res Ther 2017 Jun 5;8(1):129.
- Geburek F, Gaus M, van Schie HT, Rohn K, Stadler PM. Effect of intralesional platelet-rich plasma (PRP) treatment on clinical and ultrasonographic parameters in equine naturally occurring superficial digital flexor tendinopathies - a randomized prospective controlled clinical trial. BMC Vet Res 2016 Sep 7;12(1):191.
- Dallaudiere B, Louedec L, Lenet MP, Pesquer L, Blaise E, Perozziello A, Michel JB, Moinard M, Meyer P, Serfaty JM. The molecular systemic and local effects of intra-tendinous injection of Platelet Rich Plasma in tendinosis: preliminary results on a rat model with ELISA method. Muscles Ligaments Tendons J 2015 Apr-Jun;5(2):99-105.
- Geburek F, Lietzau M, Beineke A, Rohn K, Stadler PM. Effect of a single injection of autologous conditioned serum (ACS) on tendon healing in equine naturally occurring tendinopathies. Stem Cell Res Ther 2015 Jun 26;6(1):126.
- Dallaudiere B, Zurlinden O, Perozziello A, Deschamps L, Larbi A, Louedec L, Pesquer L, Benayoun Y, Silvestre A, Serfaty JM. Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model. Muscles Ligaments Tendons J 2014 Jul;4(3):351-6.
- Dallaudière B, Lempicki M, Pesquer L, Louedec L, Preux PM, Meyer P, Hummel V, Larbi A, Deschamps L, Journe C, Hess A, Silvestre A, Sargos P, Loriaut P, Boyer P, Schouman-Claeys E, Michel JB, Serfaty JM. Efficacy of intra-tendinous injection of platelet-rich plasma in treating tendinosis: comprehensive assessment of a rat model. Eur Radiol 2013 Oct;23(10):2830-7.
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