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The Journal of veterinary medical science2022; 85(1); 55-61; doi: 10.1292/jvms.22-0377

Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis.

Abstract: In this case report, two horses with chronic refractory infections in the tuber calcanei were successfully managed via intravenous antibiotic regional limb perfusion through the lateral saphenous vein after failure of conventional treatment approaches, including surgery and intravenous regional limb perfusion using the cranial branch of the medial saphenous vein. Surgical delay in these cases may have allowed the development of chronic infection, which prevented the conventional regional perfusion from working effectively. The spatial difference of the vessels relative to the tuber calcanei possibly contributed to the treatment outcome in these horses. This report describes a novel approach for regional antimicrobial perfusion to the equine plantar hock region using the lateral saphenous vein.
Publication Date: 2022-11-23 PubMed ID: 36418075PubMed Central: PMC9887219DOI: 10.1292/jvms.22-0377Google Scholar: Lookup
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Summary

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The research article discusses a novel approach to treating chronic refractory infections in horses through regional antibiotic perfusion via the lateral saphenous vein. Conventional treatment options failed, but this new method showed successful outcomes.

Key Elements of the Study

  • The study primarily focused on two horses suffering from chronic refractory infections, specifically in the tuber calcanei, a prominent bony area in the heel of horses.
  • Traditional treatment techniques were not effective in these instances. The approaches included surgery as well as intravenous regional limb perfusion using the cranial branch of the medial saphenous vein.
  • The report suggests that the delay in surgery may have permitted the infection to become chronic, thus reducing the efficacy of the conventional perfusion treatment.

Novel Approach and Findings

  • The researchers chose intravenous antibiotic regional limb perfusion using the lateral saphenous vein, a different vein to conventionally used for this treatment. The shift to the usage of this vein is a novel approach aimed at dealing with the chronic infections.
  • The decision to use this vein was based on its spatial location relative to the tuber calcanei. It was hypothesized that this might influence the effectiveness of the treatment.
  • The conclusion of the study affirmed that this different method of regional antimicrobial perfusion towards the equine plantar hock region (the back area of a horse’s leg just above the hoof) was successful for the two horses under study.

Implications

  • The success of the novel approach suggests it may provide a valuable alternative to current treatment strategies, particularly when those methods have proven unsuccessful.
  • This novel perfusion technique could potentially revolutionize the way certain equine infections are treated, making it a significant addition to veterinary medicine.

Cite This Article

APA
Mizuguchi Y, Kato A, Aizu M. (2022). Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis. J Vet Med Sci, 85(1), 55-61. https://doi.org/10.1292/jvms.22-0377

Publication

ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 85
Issue: 1
Pages: 55-61

Researcher Affiliations

Mizuguchi, Yuya
  • Hidaka Horse Breeders' Association, Hokkaido, Japan.
Kato, Atsushi
  • Shadai Farm, Hokkaido, Japan.
Aizu, Marina
  • Shadai Farm, Hokkaido, Japan.

MeSH Terms

  • Horses
  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Saphenous Vein
  • Osteitis / veterinary
  • Perfusion / veterinary
  • Administration, Intravenous / veterinary
  • Horse Diseases / drug therapy
  • Horse Diseases / surgery

Conflict of Interest Statement

The authors have nothing to disclose.

References

This article includes 32 references
  1. Bassage LH 2nd, Garcia-Lopez J, Currid EM. Osteolytic lesions of the tuber calcanei in two horses.. J Am Vet Med Assoc 2000 Sep 1;217(5):710-6, 674.
    doi: 10.2460/javma.2000.217.710pubmed: 10976305google scholar: lookup
  2. Biasutti SA, Cox E, Jeffcott LB, Dart AJ. A review of regional limb perfusion for distal limb infections in the horse. Equine Vet Educ 33: 263–277.
    doi: 10.1111/eve.13243google scholar: lookup
  3. Budras KD, Sack WO, Röck S, Horowitz A, Berg R. Pelvic limb. pp. 16–31. In: Anatomy of the Horse, 5th rev ed. (Budras KD, Sack WO, Röck S eds.), Schlütersche, Hannover.
  4. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms.. Annu Rev Microbiol 1995;49:711-45.
  5. Cruz AM, Rubio-Martinez L, Dowling T. New antimicrobials, systemic distribution, and local methods of antimicrobial delivery in horses.. Vet Clin North Am Equine Pract 2006 Aug;22(2):297-322, vii-viii.
    doi: 10.1016/j.cveq.2006.03.006pubmed: 16882477google scholar: lookup
  6. Duggan MJS, Mair TS. Comparison of outcomes following treatment of septic calcaneal bursitis by needle or bursoscopic lavage: A retrospective study of 29 horses. Equine Vet Educ 33: 135–142.
    doi: 10.1111/eve.13225google scholar: lookup
  7. Dyson SJ, Kidd L. Five cases of gastrocnemius tendinitis in the horse.. Equine Vet J 1992 Sep;24(5):351-6.
  8. Dyson SJ, Ross MW. The tarsus. pp. 508–526. In: Diagnosis and Management of Lameness in the Horse, 2nd ed. (Ross MW, Dyson SJ eds.), Elsevier, Philadelphia.
  9. Fails AD. Functional anatomy of the equine musculoskeletal system. pp. 1–65. In: Adams and Stashak’s Lameness in Horses, 7th ed. (Baxter GM ed.), John Wiley & Sons, Inc., Hoboken.
  10. Garcia AFS, Dória RGS, Arantes JA, Reginato GM, Neubauer FG, Ribeiro G. Intravenous Regional Limb Perfusion in Standing and Recumbent Horses: A Comparative Radiographic Study.. J Equine Vet Sci 2021 Mar;98:103373.
    doi: 10.1016/j.jevs.2021.103373pubmed: 33663721google scholar: lookup
  11. Goodrich LR. Osteomyelitis in horses.. Vet Clin North Am Equine Pract 2006 Aug;22(2):389-417, viii-ix.
    doi: 10.1016/j.cveq.2006.04.001pubmed: 16882481google scholar: lookup
  12. Ingle-Fehr JE, Baxter GM. Endoscopy of the calcaneal bursa in horses.. Vet Surg 1998 Nov-Dec;27(6):561-7.
  13. Isgren CM, Salem SE, Singer ER, Wylie CE, Lipreri G, Graham RJTY, Bladon B, Boswell JC, Fiske-Jackson AR, Mair TS, Rubio-Martínez LM. A multi-centre cohort study investigating the outcome of synovial contamination or sepsis of the calcaneal bursae in horses treated by endoscopic lavage and debridement.. Equine Vet J 2020 May;52(3):404-410.
    doi: 10.1111/evj.13180pmc: PMC7186813pubmed: 31502700google scholar: lookup
  14. Kelmer G. Regional limb perfusion in horses.. Vet Rec 2016 Jun 4;178(23):581-4.
    doi: 10.1136/vr.i3082pubmed: 27256262google scholar: lookup
  15. Kelmer G, Bell GC, Martin-Jimenez T, Saxton AM, Catasus C, Elliot SB, Meibohm B. Evaluation of regional limb perfusion with amikacin using the saphenous, cephalic, and palmar digital veins in standing horses.. J Vet Pharmacol Ther 2013 Jun;36(3):236-40.
  16. Koch C, Witte S. Septic osteitis and osteomyelitis in foals−are antimicrobials alone enough?. Equine Vet Educ 25: 67–73.
  17. MacDonald MH, Honnas CM, Meagher DM. Osteomyelitis of the calcaneus in horses: 28 cases (1972-1987).. J Am Vet Med Assoc 1989 May 1;194(9):1317-23.
    pubmed: 2722668
  18. Mattson S, Bouré L, Pearce S, Hurtig M, Burger J, Black W. Intraosseous gentamicin perfusion of the distal metacarpus in standing horses.. Vet Surg 2004 Mar-Apr;33(2):180-6.
  19. McIlwraith CW, Nixon AJ, Wright IM. Bursoscopy. pp. 387–406. In: Diagnostic and Surgical Arthroscopy in the Horse, 4th ed. (McIlwraith CW, Nixon AJ, Wright IM eds.), Mosby, St. Louis.
  20. Moser DK, Schoonover MJ, Holbrook TC, Payton ME. Effect of Regional Intravenous Limb Perfusate Volume on Synovial Fluid Concentration of Amikacin and Local Venous Blood Pressure in the Horse.. Vet Surg 2016 Oct;45(7):851-858.
    doi: 10.1111/vsu.12521pubmed: 27509840google scholar: lookup
  21. Post EM, Singer ER, Clegg PD. An anatomic study of the calcaneal bursae in the horse.. Vet Surg 2007 Jan;36(1):3-9.
  22. Post EM, Singer ER, Clegg PD, Smith RK, Cripps PJ. Retrospective study of 24 cases of septic calcaneal bursitis in the horse.. Equine Vet J 2003 Nov;35(7):662-8.
    doi: 10.2746/042516403775696285pubmed: 14649357google scholar: lookup
  23. Redding LE, Elzer EJ, Ortved KF. Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: A meta-analysis.. PLoS One 2022;17(4):e0265971.
  24. Richardson DW, Stewart S. Synovial and osseous infection. pp. 1458–1470. In: Equine Surgery, 5th ed. (Auer JA, Stick JA, Kümmerle JM, Prange T eds.), Elsevier, St. Louis.
  25. Rubio-Martínez LM, Cruz AM. Antimicrobial regional limb perfusion in horses.. J Am Vet Med Assoc 2006 Mar 1;228(5):706-12, 655.
    doi: 10.2460/javma.228.5.706pubmed: 16506931google scholar: lookup
  26. Rubio-Martínez LM, Elmas CR, Black B, Monteith G. Clinical use of antimicrobial regional limb perfusion in horses: 174 cases (1999-2009).. J Am Vet Med Assoc 2012 Dec 15;241(12):1650-8.
    doi: 10.2460/javma.241.12.1650pubmed: 23216042google scholar: lookup
  27. Scheuch BC, Van Hoogmoed LM, Wilson WD, Snyder JR, MacDonald MH, Watson ZE, Steffey EP. Comparison of intraosseous or intravenous infusion for delivery of amikacin sulfate to the tibiotarsal joint of horses.. Am J Vet Res 2002 Mar;63(3):374-80.
    doi: 10.2460/ajvr.2002.63.374pubmed: 11911572google scholar: lookup
  28. Schoonover MJ, Moser DK, Young JM, Payton ME, Holbrook TC. Effects of tourniquet number and exsanguination on amikacin concentrations in the radiocarpal and distal interphalangeal joints after low volume intravenous regional limb perfusion in horses.. Vet Surg 2017 Jul;46(5):675-682.
    doi: 10.1111/vsu.12662pubmed: 28460426google scholar: lookup
  29. Shummer A, Wilkens H, Vollmerhaus B, Habermehl KH. Veins (venae). pp. 184–268. In: The Circulatory System, the Skin, and the Cutaneous Organs of the Domestic Mammals (Shummer A, Wilkens H, Vollmerhaus B, Habermehl K-H eds.), Springer, New York.
  30. Vajs T, Nekouei O, Biermann NM. A Descriptive Study of the Clinical Presentation, Management, and Outcome of Horses with Acute Soft Tissue Trauma of the Tarsus and the Association with Synovial Involvement.. Animals (Basel) 2022 Feb 21;12(4).
    doi: 10.3390/ani12040524pmc: PMC8868076pubmed: 35203232google scholar: lookup
  31. Wereszka MM, White NA 2nd, Furr MO. Factors associated with outcome following treatment of horses with septic tenosynovitis: 51 cases (1986-2003).. J Am Vet Med Assoc 2007 Apr 15;230(8):1195-200.
    doi: 10.2460/javma.230.8.1195pubmed: 17501662google scholar: lookup
  32. Whitehair KJ, Blevins WE, Fessler JF, Van Sickle DC, White MR, Bill RP. Regional perfusion of the equine carpus for antibiotic delivery.. Vet Surg 1992 Jul-Aug;21(4):279-85.

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