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Theriogenology2005; 65(8); 1605-1619; doi: 10.1016/j.theriogenology.2005.08.024

Regression and resurgence of the CL following PGF2alpha treatment 3 days after ovulation in mares.

Abstract: The present study was designed to characterize and compare the physiology and ultrasonographic morphology of the corpus luteum (CL) during regression and resurgence following a single dose of native prostaglandin F2alpha (PGF) given 3 days after ovulation, with a more conventional treatment given 10 days after ovulation. On the day of pre-treatment ovulation (Day 0), horse mares were randomly assigned to receive PGF (Lutalyse; 10 mg/mare, i.m.) on Day 3 (17 mares) or Day 10 (17 mares). Beginning on either Days 3 or 10, follicle and CL data and blood samples were collected daily until post-treatment ovulation. Functional and structural regression of the CL in response to PGF treatment were similar in both the Day 3 and 10 groups, as indicated by an abrupt decrease in circulating concentrations of progesterone, decrease in luteal gland diameter and increase in luteal tissue echogenicity. As a result, the mean +/- S.E.M. interovulatory interval was shorter (P < 0.0001) in the Day 3 group (13.2 +/- 0.9 days) than in the Day 10 group (19.2 +/- 0.7 days). Within the Day 3 group, functional resurgence of the CL was detected in 75% of the mares (12 of 16) beginning 3 days after PGF treatment, as indicated by transient major (6 mares) and minor (6 mares) increases (P < 0.05 and < 0.1, respectively) in progesterone. Correspondingly, mean length of the interovulatory interval was longer (P < 0.03) in mares with major resurgence (15.8 +/- 1.6 days) than in mares with minor (11.2 +/- 1.2 days) and no resurgences (13.5 +/- 0.3 days) in progesterone. Structural resurgence of the CL in the Day 3 group and functional and structural resurgence in the Day 10 group were not detected. In conclusion, PGF treatment 3 days after ovulation resulted in structural and functional regression of the CL and hastened the interval to the next ovulation, despite post-treatment resurgences in progesterone.
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Publication Date: 2005-10-20 PubMed ID: 16242763DOI: 10.1016/j.theriogenology.2005.08.024Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examines the effects of a type of hormone treatment on the reproductive cycles of mares, specifically looking at the differences when given at different time points after ovulation. The researchers found that administering the hormone three days after ovulation leads to a quicker return to ovulation, despite temporary increases in progesterone.

Research Goals

The researchers aim to understand and compare the physiological and ultrasound morphology changes in the corpus luteum (CL), a temporary endocrine structure in female mammals, during regression and resurgence after administering prostaglandin F2alpha (PGF), a hormone-like compound, 3 days and 10 days after ovulation.

Study Design

  • The study involved 34 randomly selected horse mares who were given a prostaglandin F2alpha (PGF) treatment 3 days (17 mares) or 10 days (17 mares) after ovulation.
  • Every day from day 3 or day 10 until the next ovulation, physical data and blood samples were collected from the mares to track follicular and CL progression.

Findings

  • The results showed similar physical and functional CL regression in both groups after PGF treatment. This was indicated by decreased progesterone levels, luteal gland size, and increased luteal tissue density.
  • The average time between ovulations was shorter in the group treated on day 3 than the group treated on day 10.
  • In the day 3 group, three-quarters of mares showed a functional revival of the CL a few days after PGF treatment, noted by increases in progesterone levels. This revival was divided into noteworthy (‘major’) or slight (‘minor’).
  • The length of time between ovulations was longer in mares with noticeable (‘major’) resurgence.
  • No functional or physical resurgence of the CL was observed in the day 10 group.

Conclusion

Administering PGF treatment 3 days after ovulation resulted in both physical and functional regression of the CL and accelerated the interval to the next ovulation, despite temporary increases in progesterone. This research indicates that the timing of hormone treatment plays a significant role in ovulation cycle management in mares.

Cite This Article

APA
Bergfelt DR, Pierson RA, Ginther OJ. (2005). Regression and resurgence of the CL following PGF2alpha treatment 3 days after ovulation in mares. Theriogenology, 65(8), 1605-1619. https://doi.org/10.1016/j.theriogenology.2005.08.024

Publication

Theriogenology
ISSN: 0093-691X
NlmUniqueID: 0421510
Country: United States
Language: English
Volume: 65
Issue: 8
Pages: 1605-1619

Researcher Affiliations

Bergfelt, D R
  • Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA. bergfelt@svm.vetmed.wisc.edu
Pierson, R A
    Ginther, O J

      MeSH Terms

      • Animals
      • Corpus Luteum / diagnostic imaging
      • Corpus Luteum / drug effects
      • Corpus Luteum / physiology
      • Dinoprost / pharmacology
      • Female
      • Horses / physiology
      • Ovarian Follicle / anatomy & histology
      • Ovarian Follicle / drug effects
      • Ovulation / physiology
      • Progesterone / blood
      • Random Allocation
      • Time Factors
      • Ultrasonography

      Citations

      This article has been cited 5 times.
      1. Silva ESM, Newcombe JR, Cuervo-Arango J. The Effect of Treatment with Oestradiol Benzoate on Oestrus Expression and Endometrial Oedema in Anovulatory and Cyclic Mares. Animals (Basel) 2023 Mar 5;13(5).
        doi: 10.3390/ani13050938pubmed: 36899795google scholar: lookup
      2. Newcombe JR, Wilsher S, Cuervo-Arango J. The post-ovulatory rise in progesterone is lower and the persistence of oestrous behaviour longer during the first compared with the second cycle of the breeding season in mares. Reprod Domest Anim 2023 Jan;58(1):141-145.
        doi: 10.1111/rda.14273pubmed: 36177828google scholar: lookup
      3. Bottrel M, Ortiz I, Hidalgo M, Díaz-Jiménez M, Pereira B, Consuegra C, Yousef MS, Dorado J. Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate. Animals (Basel) 2022 Jan 8;12(2).
        doi: 10.3390/ani12020143pubmed: 35049767google scholar: lookup
      4. Okada CTC, Kaps M, Perez Quesada J, Gautier C, Aurich J, Aurich C. Diestrous Ovulations in Pregnant Mares as a Response to Low Early Postovulatory Progestogen Concentration. Animals (Basel) 2020 Nov 30;10(12).
        doi: 10.3390/ani10122249pubmed: 33266083google scholar: lookup
      5. Wenzinger B, Bleul U. Effect of a prostaglandin F2α analogue on the cyclic corpus luteum during its refractory period in cows. BMC Vet Res 2012 Nov 14;8:220.
        doi: 10.1186/1746-6148-8-220pubmed: 23151276google scholar: lookup
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