Relationship between peripartal plasma oxytocin and prostaglandin F(2alpha) metabolite and placental expulsion time in heavy draft mares.
Abstract: The aim of this study was to clarify the relationship between circulating oxytocin (OT) and PGF(2alpha) metabolite (PGFM) in mares at the third stage of labor and placental expulsion time in order to investigate a cause of retained placenta of which the incidence increase in a heavy draft mare. Blood was sampled every 5 min from foaling to expulsion of the placenta in 18 heavy draft mares to evaluate circulating OT and PGFM. The relationships between OT and PGFM concentration and recorded placental expulsion times were investigated. The results were as follows (1) The highest level of OT concentration was observed close to foaling in 15 mares. (2) The OT concentrations close to foaling were variable with a large difference from the lowest concentration, 22.1 pg/ml, to the highest concentration, 209.3 pg/ml. (3) The highest level of PGFM was observed close to foaling in 17 mares. (4) During the 60 min following foaling, the OT concentrations of the mares (n=11) that had a shorter placental expulsion time (i.e., <1 h), were significantly higher than those of the mares (n=7) that had a longer placental expulsion time (i.e., >1 h; P<0.05). Collectively, the OT concentration immediately after foaling is negatively related to the placental expulsion time. Deficiency of OT secretion at foaling have should be considered as one of the causes of retained placenta in heavy draft mares.
Publication Date: 2008-05-22 PubMed ID: 18496017DOI: 10.1262/jrd.19154Google Scholar: Lookup
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- Journal Article
Summary
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The study investigates the relationship between the levels of oxytocin and PGF(2alpha) metabolite in the blood of heavy draft mares during late-stage labor, and the time it takes for the placenta to be expelled, aiming to understand the cause of the retained placenta.
Objective of the Study
- This research aims to understand the cause of retained placenta in heavy draft mares, a condition known to be more common in these animals.
- The researchers focused on investigating the relationship between the levels of oxytocin and PGF(2alpha) metabolite in the blood during the third stage of labor and the time it takes for the placenta to be expelled.
Methodology
- The study involved 18 heavy draft mares.
- Blood samples were collected every five minutes from the onset of foaling until the expulsion of the placenta.
- The concentrations of oxytocin and PGF(2alpha) metabolite in the blood were measured and recorded.
- The researchers then investigated the relationships between the levels of these substances and the recorded times of placental expulsion.
Findings
- The highest concentration of oxytocin was found around the time of foaling in 15 of the 18 mares included in the study.
- However, the concentration of oxytocin varied greatly during this period, ranging from 22.1 pg/ml (picograms per milliliter) to 209.3 pg/ml.
- Similarly, the highest level of PGF(2alpha) metabolite was observed close to foaling in 17 of the mares.
- Significantly, the 11 mares that had shorter placental expulsion times (less than an hour) had significantly higher concentrations of oxytocin in the first 60 minutes following foaling compared to the 7 mares that took longer to expel the placenta (more than an hour).
Conclusions
- The study concludes that the concentration of oxytocin in the mare’s blood immediately after foaling is inversely related to the time it takes for the placenta to be expelled.
- A low secretion of oxytocin at the time of foaling could possibly be one of the causes of retained placenta in heavy draft mares, according to the study’s findings.
Cite This Article
APA
Ishii M, Kobayashi S, Acosta TJ, Miki W, Yamanoi T, Matsui M, Miyake Y, Miyamoto A.
(2008).
Relationship between peripartal plasma oxytocin and prostaglandin F(2alpha) metabolite and placental expulsion time in heavy draft mares.
J Reprod Dev, 54(4), 270-274.
https://doi.org/10.1262/jrd.19154 Publication
Researcher Affiliations
- Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan. mishii@obihiro.ac.jp
MeSH Terms
- Animals
- Animals, Newborn
- Dinoprost / blood
- Dinoprost / metabolism
- Female
- Horses / blood
- Horses / physiology
- Labor, Obstetric / blood
- Labor, Obstetric / physiology
- Oxytocin / blood
- Parturition / blood
- Placenta / physiology
- Pregnancy
- Pregnancy, Animal
- Time Factors
Citations
This article has been cited 4 times.- Niikura T, Tsogtgerel M, Niikura C, Wada H, Kanzawa S, Fujiwara T, Nambo Y. Effect of prostaglandin F2(α) administration on uterine polymorphonuclear neutrophil counts in Japanese heavy draft horses. J Equine Sci 2021 Dec;32(4):117-124.
- Bienboire-Frosini C, Chabaud C, Cozzi A, Codecasa E, Pageat P. Validation of a Commercially Available Enzyme ImmunoAssay for the Determination of Oxytocin in Plasma Samples from Seven Domestic Animal Species. Front Neurosci 2017;11:524.
- Patwardhan M, Hernandez-Andrade E, Ahn H, Korzeniewski SJ, Schwartz A, Hassan SS, Romero R. Dynamic Changes in the Myometrium during the Third Stage of Labor, Evaluated Using Two-Dimensional Ultrasound, in Women with Normal and Abnormal Third Stage of Labor and in Women with Obstetric Complications. Gynecol Obstet Invest 2015;80(1):26-37.
- Ishii M, Aoki T, Yamakawa K, Magata F, Gojo C, Ito K, Kayano M, Nambo Y. Relationship between the Placental Retention Time and the Reproductive Performance at the Foal Heat in Thoroughbred and a Comparison with Heavy Draft. J Equine Sci 2013;24(2):25-9.
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