Relationship of cadmium accumulation to zinc or copper concentration in horse liver and kidney.
Abstract: The concentrations of Cd, Zn, Cu, and metallothionein (MT) in the liver, renal cortex, and renal medulla were determined in 24 male and 15 female younger thoroughbreds (age 27 to 97 months) and two old male horses (age 154 months and 190 months). High correlations were found between Zn and MT in the liver (partial correlation coefficient 0.836), between Cd and MT in the renal cortex (partial correlation coefficient 0.786), and between Cd and Zn in the renal cortex (partial correlation coefficient 0.675), while the correlation between Cd and MT in the liver was low (partial correlation coefficient 0.124). In the renal medulla, high correlations were found between Cd and Zn (partial correlation coefficient -0.631), between Zn and Cu (partial correlation coefficient 0.881), and between Cd and Cu (partial correlation coefficient 0.785). Therefore, in the liver, the MT concentration is the most highly correlated with the Zn concentration and is not correlated with the CD concentration unless artificially exposed to Cd. In the renal cortex, the MT and Cd concentrations are very highly correlated with each other. The Zn concentration is about 20 micrograms/g when the Cd concentration in the renal cortex is the lowest.
Publication Date: 1989-06-01 PubMed ID: 2721471DOI: 10.1016/s0013-9351(89)80025-8Google Scholar: Lookup
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- Journal Article
Summary
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The research article explores the connection between the accumulation of the heavy metal cadmium and the concentrations of zinc and copper found in the livers and kidneys of horses, with distinct connections identified in regards to the protein metallothionein.
Understanding the Study
- The study involved conducting tests on the liver, renal cortex, and renal medulla of both younger and older thoroughbred horses. The subjects ranged from 27 months to 190 months old.
- The heavy metals cadmium (Cd), zinc (Zn), and copper (Cu), along with the protein metallothionein (MT), were the substances of interest.
Findings of the Research
- The results demonstrated variable relationships between the substances based on the different bodily tissues.
- In the liver, a strong correlation is noted between the concentrations of Zn and MT, which implies a high degree of zinc is associated with MT in this organ. However, the correlation between MT and Cd in the liver is very weak.
- In the renal cortex, MT concentrations and Cd levels are strongly correlated. This indicates that in kidney tissue, the concentration of MT is associated with the presence of cadmium. Moreover, a positive significant correlation was established between Cd and Zn in the renal cortex.
- Unlike the liver and renal cortex, in the renal medulla, Cd and Zn have a negatively high correlation. High correlations were also observed between Zn and Cu, and Cd and Cu in the renal medulla.
The Key Takeaways
- The most notable conclusion derived from this study is the association of MT levels with Zn and Cd levels. In the liver, the concentration of MT appears to be most highly correlated with the Zn levels, while in the renal cortex, Cd seems to be predominantly associated.
- Despite this, it’s important to note that Cd does not appear to impact MT levels in the liver unless there is an artificial exposure to Cd.
- The concentration of zinc in the renal cortex is around 20 micrograms/g when the Cd concentration is at its lowest in this organ.
Importance of the Study
- This research provides significant insights into the physiological relationships and influence of heavy metals and proteins within equine bodies. This could be utilized in understanding and monitoring equine health, particularly in regions with heavy metal exposure.
Cite This Article
APA
Koizumi N, Inoue Y, Ninomiya R, Fujita D, Tsukamoto T.
(1989).
Relationship of cadmium accumulation to zinc or copper concentration in horse liver and kidney.
Environ Res, 49(1), 104-114.
https://doi.org/10.1016/s0013-9351(89)80025-8 Publication
Researcher Affiliations
- Department of Public Health, Hyogo College of Medicine, Japan.
MeSH Terms
- Animal Feed
- Animals
- Cadmium / metabolism
- Chromatography, High Pressure Liquid
- Copper / metabolism
- Female
- Horses / metabolism
- Kidney / metabolism
- Liver / metabolism
- Male
- Metallothionein / metabolism
- Zinc / metabolism
Citations
This article has been cited 3 times.- Pabis K, Chiari Y, Sala C, Straka E, Giacconi R, Provinciali M, Li X, Brown-Borg H, Nowikovsky K, Valencak TG, Gundacker C, Garagnani P, Malavolta M. Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging. Geroscience 2021 Aug;43(4):1975-1993.
- Paßlack N, Mainzer B, Lahrssen-Wiederholt M, Schafft H, Palavinskas R, Breithaupt A, Neumann K, Zentek J. Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium and lead in the equine liver and kidneys. Springerplus 2014;3:343.
- Ninomiya R, Koizumi N, Fujita D. Effect of cadmium administration and aging on the concentration of essential metals in liver and kidney. Environ Health Prev Med 1997 Jan;1(4):178-83.
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