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Removal of deslorelin (Ovuplant) implant 48 h after administration results in normal interovulatory intervals in mares.
Abstract: Deslorelin implants, approved for use in inducing ovulation in mares, have been associated with prolonged interovulatory intervals in some mares. Administration of prostaglandins in the diestrous period, following a deslorelin-induced ovulation, has been reported to increase the incidence of delayed ovulations. The goals of the present study were: (1) to determine the percentage of mares given deslorelin that experience delayed ovulations with or without subsequent prostaglandin treatment, and (2) to determine if removal of the implant 48 h after administration would effect the interval to subsequent ovulation. We considered interovulatory intervals to be prolonged if they were greater than the mean +/- 2 standard deviation (S.D.) of the control group in study 1 and the hCG group in study 2. In study 1, we retrospectively reviewed reproduction records for 278 mares. We either allowed the mare to ovulate spontaneously or induced ovulation using deslorelin acetate implants or hCG. We administered prostaglandin intramuscularly, 5-9 days after ovulation in selected mares in each group. A higher percentage of mares which were induced to ovulate with deslorelin and given prostaglandins had a prolonged interovulatory interval (23.5%; n = 16), as compared to deslorelin-treated mares that did not receive prostaglandins (11.1%; n = 5). In study 2, we induced ovulation in mares with hCG (n = 47), a subcutaneous deslorelin implant via an implanting device provided by the manufacturer (n = 28), or a deslorelin implant via an incision in the neck (n = 43) and we removed the implant 48 h after administration. We administered prostaglandin to all mares 5-9 days after ovulation. In study 2, mares from which the implant was removed had a normal ovulation rate and none had a prolonged interval to ovulation. Administration of prostaglandin after deslorelin treatment was associated with a longer interval from luteolysis to ovulation than that found in mares not treated with deslorelin. Prostaglandin administration during diestrus may have exacerbated the increased interval to ovulation in deslorelin-treated mares. We hypothesize that prolonged secretion of deslorelin from the implant was responsible for the extended interovulatory intervals.
Publication Date: 2002-09-06 PubMed ID: 12212887DOI: 10.1016/s0093-691x(02)00923-8Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research investigates the effects of Deslorelin implants, used to induce ovulation in mares, on the interval between ovulations. Specifically, the study assesses the impact of removing the implant 48 hours after its administration and the influence of additional prostaglandin treatment.
Research Objective
The study aimed to determine whether the Deslorelin implants, used for inducing ovulation in horses, led to delayed ovulations, particularly when paired with prostaglandin treatment administered during the diestrous period (between two ovulation cycles). Additionally, it studied whether removing the Deslorelin implant 48 hours after administration impacted the interval to the next ovulation.
- The study had two key objectives. The first was to figure out the percentage of mares given Deslorelin that had delayed ovulations, with or without the subsequent prostaglandin treatment. The second objective was to reveal if the removal of the implant 48 hours after its administration would affect the interval to the next ovulation.
Methodology
The research executed two studies using different groups of mares.
- In the first study, the reproductive records of 278 mares were reviewed retrospectively. These mares either ovulated spontaneously or were induced to ovulate using Deslorelin acetate implants or hCG (Human Chorionic Gonadotropin). Selected mares from each group received an intramuscular application of prostaglandin 5-9 days after ovulation. The results were assessed by measuring the interovulatory periods.
- In the second study, ovulation was induced in mares using hCG, a subcutaneous Deslorelin implant via a manufacturer-provided implanting device, or a Deslorelin implant via an incision in the neck. The implant was removed from all chosen mares 48 hours after administration and prostaglandin was administered 5–9 days after ovulation. Again, the results were analyzed based on the length between ovulations.
Findings
The study found that Deslorelin implants and prostaglandin treatment could impact the ovulation cycle.
- In the first study, they discovered a higher percentage of mares that were induced to ovulate with Deslorelin and given prostaglandins had an extended interovulatory interval, compared to those Deslorelin-treated mares that did not receive prostaglandins.
- The second study showed that mares from which the Deslorelin implant was removed 48 hours after administration had a normal ovulation rate and none suffered from a prolonged interval to subsequent ovulation. Further, when prostaglandin was administered after the Deslorelin treatment, a longer interval was noticed from luteolysis (decline in progesterone production) to ovulation as compared to non-Deslorelin treated mares.
- Based on these outcomes, researchers deduced that the prolonged secretion of Deslorelin from the implant might be associated with the extended interovulatory intervals, and prostaglandin administration during the diestrous phase could raise the interval to ovulation in Deslorelin-treated mares.
Cite This Article
APA
McCue PM, Farquhar VJ, Carnevale EM, Squires EL.
(2002).
Removal of deslorelin (Ovuplant) implant 48 h after administration results in normal interovulatory intervals in mares.
Theriogenology, 58(5), 865-870.
https://doi.org/10.1016/s0093-691x(02)00923-8 Publication
Researcher Affiliations
- Animal Reproduction and Biotechnology Laboratory, Colorado State University, Ft Collins 80523, USA. patrick.mccue@colostate.edu
MeSH Terms
- Animals
- Chorionic Gonadotropin / administration & dosage
- Cloprostenol / administration & dosage
- Drug Implants
- Female
- Gonadotropin-Releasing Hormone / administration & dosage
- Gonadotropin-Releasing Hormone / analogs & derivatives
- Horses
- Humans
- Ovulation
- Ovulation Induction / veterinary
- Retrospective Studies
- Time Factors
- Triptorelin Pamoate / analogs & derivatives
Citations
This article has been cited 4 times.- Aurich C, Kaps M. Suppression of reproductive behaviour and gonadal function in female horses-An update. Reprod Domest Anim 2022 Sep;57 Suppl 4(Suppl 4):4-12.
- Kaps M, Okada CTC, Gautier CM, Aurich J, Aurich C. Deslorelin Slow-Release Implants Delay Ovulation and Increase Plasma AMH Concentration and Small Antral Follicles in Haflinger Mares. Animals (Basel) 2021 May 28;11(6).
- McKenna J, Bellofiore N, Catt S, Pangestu M, Temple-Smith P. A human-based assisted reproduction protocol for the menstruating spiny mouse, Acomys cahirinus. PLoS One 2020;15(12):e0244411.
- Miki W, Oniyama H, Takeda N, Kimura Y, Haneda S, Matsui M, Taya K, Nambo Y. Effects of a single use of the GnRH analog buserelin on the induction of ovulation and endocrine profiles in heavy draft mares. J Equine Sci 2016;27(4):149-156.
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