Renal replacement therapy in healthy adult horses.
Abstract: Renal replacement therapy (RRT) has been implemented extensively in people to facilitate recovery from acute renal failure (ARF). RRT has not been explored in horses, but might provide a further treatment option in horses with ARF. Objective: To investigate efficacy and safety of RRT in horses. Methods: Five healthy adult horses. Methods: A prospective study was performed on horses restrained in stocks and intravenously connected to a commercial RRT machine to allow continuous venovenous hemodiafiltration to be performed for 6 hours. The RRT machine was set at the following flow rates: blood flow rate 250 mL/min; dialysate rate 3,000 mL/h; prefilter replacement pump 3,000 mL/h; and postfilter replacement pump rate 2,000 mL/h. Balanced electrolyte solution was used as dialysate and replacement fluid. Heart rate, respiratory rate, body temperature, direct arterial blood pressure, urine output, and various clinicopathologic parameters were measured over the study period. Results: Renal replacement therapy was successfully performed in horses, resulting in a mean creatinine clearance of 0.127 mL/kg/min (68.9 mL/min) and urea reduction ratio of 24%. No adverse effects were detected although a significant decrease in rectal temperature was observed (P ≤ .007). A significant increase in serum phosphorus (P ≤ .001) and decrease in BUN (P < .001) were also noted. A significant prolongation of prothrombin (P < .01) and partial thromboplastin time (P < .0001) were observed along with a decrease in platelet count (P ≤ .04). Conclusions: Renal replacement therapy can safely and effectively be used in adult horses.
Copyright © 2013 by the American College of Veterinary Internal Medicine.
Publication Date: 2013-03-04 PubMed ID: 23458828DOI: 10.1111/jvim.12049Google Scholar: Lookup
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- Journal Article
Summary
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This research explores the use of Renal Replacement Therapy (RRT) in horses and validates its effectiveness and safety in treating acute renal failure.
Research Overview
In this study, the researchers investigated the viability and safety of Renal Replacement Therapy (RRT) as a treatment option for horses suffering from Acute Renal Failure (ARF). Previous studies have shown that RRT is a successful treatment in humans for ARF, but its applications in the veterinary world have not been thoroughly explored. The objective was to see if this therapy known for its positive results in humans could be safely and efficiently applied to horses as well.
Methods
- The study included five healthy adult horses.
- Renal Replacement Therapy was performed on the same horses for six hours. In the procedure, the horses were restrained and connected to a commercial RRT machine. The machine was operated with specific flow rates set to facilitate continuous venovenous hemodiafiltration.
- Throughout the procedure, vital parameters such as heart rate, respiratory rate, body temperature, arterial blood pressure, and urine output, along with several clinicopathologic factors, were monitored and measured.
Findings
- The results showed that RRT was successful in horses, with an average creatinine clearance of 0.127 mL/kg/min and a urea reduction ratio of 24%.
- No adverse effects were detected during the study, but there was a significant decrease in rectal temperature.
- Also, significant changes in serum phosphorus, BUN (Blood Urea Nitrogen), prothrombin time, partial thromboplastin time, and platelet count were observed. Specifically, there was an increase in serum phosphorus levels, a decrease in BUN levels, a lengthening of prothrombin and partial thromboplastin time, and a decrease in platelet count.
Conclusion
The research concluded that Renal Replacement Therapy is effective and can be used safely in adult horses. This brings a potential new treatment approach for horses with Acute Renal Failure, expanding the scope of veterinary medicine and paving way for improved treatments for animals.
Cite This Article
APA
Wong DM, Witty D, Alcott CJ, Sponseller BA, Wang C, Hepworth K.
(2013).
Renal replacement therapy in healthy adult horses.
J Vet Intern Med, 27(2), 308-316.
https://doi.org/10.1111/jvim.12049 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Lloyd Veterinary Medical Center, Iowa State University, Ames, IA, USA. dwong@iastate.edu
MeSH Terms
- Acute Kidney Injury / therapy
- Acute Kidney Injury / veterinary
- Animals
- Blood Pressure / physiology
- Body Temperature / physiology
- Creatinine / blood
- Creatinine / urine
- Female
- Heart Rate / physiology
- Horse Diseases / blood
- Horse Diseases / physiopathology
- Horse Diseases / therapy
- Horse Diseases / urine
- Horses
- Partial Thromboplastin Time / veterinary
- Platelet Count / veterinary
- Prospective Studies
- Prothrombin Time / veterinary
- Renal Replacement Therapy / methods
- Renal Replacement Therapy / veterinary
- Respiratory Rate / physiology
Citations
This article has been cited 3 times.- Fouché N, Graubner C, Lanz S, Schweighauser A, Francey T, Gerber V. Acute kidney injury due to Leptospira interrogans in 4 foals and use of renal replacement therapy with intermittent hemodiafiltration in 1 foal. J Vet Intern Med 2020 Mar;34(2):1007-1012.
- Wong DM, Ruby RE, Eatroff A, Yaeger MJ. Use of Renal Replacement Therapy in a Neonatal Foal with Postresuscitation Acute Renal Failure. J Vet Intern Med 2017 Mar;31(2):593-597.
- Pinnell EF, Her J, Gordon D, Kinsella HM, Langston CE, Toribio RE. Successful hemodialysis treatment of a Quarter Horse mare with silver maple leaf toxicity and acute kidney injury. J Vet Intern Med 2024 Jul-Aug;38(4):2399-2403.
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