Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hólar, Iceland, June 2007.
Abstract: Allergic diseases occur in most mammals, although some species such as humans, dogs and horses seem to be more prone to develop allergies than others. In horses, insect bite hypersensitivity (IBH), an allergic dermatitis caused by bites of midges, and recurrent airway obstruction (RAO), a hyperreactivity to stable born dust and allergens, are the two most prevalent allergic diseases. Allergic diseases involve the interaction of three major factors: (i) genetic constitution, (ii) exposure to allergens, and (iii) a dysregulation of the immune response determined by (i) and (ii). However, other environmental factors such as infectious diseases, contact with endotoxin and degree of infestation with endoparasites have been shown to influence the prevalence of allergic diseases in humans. How these factors may impact upon allergic disease in the horse is unknown at this time. The 3rd workshop on Allergic Diseases of the Horse, with major sponsorship from the Havemeyer Foundation, was held in Hólar, Iceland, in June 2007 and focussed on immunological and genetic aspects of IBH and RAO. This particular venue was chosen because of the prevalence of IBH in exported Icelandic horses. The incidence of IBH is significantly different between Icelandic horses born in Europe or North America and those born in Iceland and exported as adults. Although the genetic factors and allergens are the same, exported adult horses show a greater incidence of IBH. This suggests that environmental or epigenetic factors may contribute to this response. This report summarizes the present state of knowledge and summarizes important issues discussed at the workshop.
Publication Date: 2008-07-31 PubMed ID: 18775570DOI: 10.1016/j.vetimm.2008.07.008Google Scholar: Lookup
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- Congress
- Research Support
- Non-U.S. Gov't
- Allergies
- Animal Health
- Animal Science
- Clinical Study
- Diagnosis
- Disease Diagnosis
- Disease Etiology
- Environmental Stressors
- Epidemiology
- Equine Diseases
- Equine Health
- Equine Studies
- Genetics
- Horses
- Icelandic Horses
- Immune Response
- Immunology
- Insect Bite Hypersensitivity
- Recurrent Airway Obstruction
- Veterinary Medicine
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article is about a workshop that focussed on studying the genetic and immunological aspects of two common allergic diseases in horses, Insect Bite Hypersensitivity (IBH) and Recurrent Airway Obstruction (RAO), and the factors affecting their prevalence.
Overview of the Workshop
- The 3rd Havemeyer workshop on allergic diseases was held in Hólar, Iceland, in 2007 with the help of the Havemeyer Foundation.
- The purpose of the meeting was to explore the genetic and immunological factors of the two most common allergic diseases in horses, Insect Bite Hypersensitivity (IBH) and Recurrent Airway Obstruction (RAO).
Insect Bite Hypersensitivity and Recurrent Airway Obstruction
- IBH is a type of allergic dermatitis in horses caused by midge bites, and RAO is an extreme reaction to stable dust and allergens.
- Allergic diseases such as these develop as a result of interplay between three primary elements: the genetic makeup of the individual, exposure to allergens, and dysregulation of the immune response, which is determined by the first two factors.
Additional Contributing Factors
- Aside from genetic constitution and allergen exposure, other environmental factors such as infectious diseases, exposure to endotoxins, and the level of endoparasitic infestation could also play a role in the prevalence of these diseases.
- The impact of these additional factors on the prevalence of allergies in horses is still unknown and required further investigation.
Significance of Study Location
- The workshop was hosted in Hólar, Iceland, due to the high incidence of IBH found in exported Icelandic horses.
- The frequency of the disease differed significantly between Icelandic horses born in Europe or North America and those born and exported as adults from Iceland.
- Even though genetic factors and allergens remained constant, exported adult horses showed a higher degree of IBH incidence, hinting towards environmental or epigenetic factors contributing to this reaction.
Present State of Knowledge
- This research summarizes the current understanding of the allergic diseases in horses and highlights the crucial issues discussed during the workshop.
- The findings of the research shed light on the importance of genetic, immunological, environmental and possibly epigenetic factors in the prevalence of common allergic diseases in horses.
Cite This Article
APA
Marti E, Gerber V, Wilson AD, Lavoie JP, Horohov D, Crameri R, Lunn DP, Antczak D, Björnsdóttir S, Björnsdóttir TS, Cunningham F, Dérer M, Frey R, Hamza E, Horin P, Heimann M, Kolm-Stark G, Olafsdóttir G, Ramery E, Russell C, Schaffartzik A, Svansson V, Torsteinsdóttir S, Wagner B.
(2008).
Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hólar, Iceland, June 2007.
Vet Immunol Immunopathol, 126(3-4), 351-361.
https://doi.org/10.1016/j.vetimm.2008.07.008 Publication
Researcher Affiliations
- Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Berne, 3001 Berne, Switzerland.
MeSH Terms
- Airway Obstruction / genetics
- Airway Obstruction / immunology
- Airway Obstruction / veterinary
- Animals
- Genetic Predisposition to Disease / genetics
- Horse Diseases / genetics
- Horse Diseases / immunology
- Horse Diseases / pathology
- Horses
- Hypersensitivity / genetics
- Hypersensitivity / immunology
- Hypersensitivity / pathology
- Hypersensitivity / veterinary
- Insect Bites and Stings / immunology
- Insect Bites and Stings / veterinary
Citations
This article has been cited 12 times.- Simões J, Sales Luís JP, Madeira de Carvalho L, Tilley P. Severely Asthmatic Horses Residing in a Mediterranean Climate Shed a Significantly Lower Number of Parasite Eggs Compared to Healthy Farm Mates. Animals (Basel) 2023 Sep 15;13(18).
- Raza F, Ivanek R, Freer H, Reiche D, Rose H, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Wagner B. Cul o 2 specific IgG3/5 antibodies predicted Culicoides hypersensitivity in a group imported Icelandic horses. BMC Vet Res 2020 Aug 10;16(1):283.
- Wilkołek P, Szczepanik M, Sitkowski W, Rodzik B, Pluta M, Taszkun I, Gołyński M. Evaluation of multiple allergen simultaneous (sIgE) testing compared to intradermal testing in the etiological diagnosis of atopic dermatitis in horses. J Vet Sci 2019 Nov;20(6):e60.
- Torsteinsdottir S, Scheidegger S, Baselgia S, Jonsdottir S, Svansson V, Björnsdottir S, Marti E. A prospective study on insect bite hypersensitivity in horses exported from Iceland into Switzerland. Acta Vet Scand 2018 Nov 3;60(1):69.
- Bond S, Léguillette R, Richard EA, Couetil L, Lavoie JP, Martin JG, Pirie RS. Equine asthma: Integrative biologic relevance of a recently proposed nomenclature. J Vet Intern Med 2018 Nov;32(6):2088-2098.
- Hamza E, Mirkovitch J, Steinbach F, Marti E. Regulatory T cells in early life: comparative study of CD4+CD25high T cells from foals and adult horses. PLoS One 2015;10(3):e0120661.
- Kehrli D, Jandova V, Fey K, Jahn P, Gerber V. Multiple hypersensitivities including recurrent airway obstruction, insect bite hypersensitivity, and urticaria in 2 warmblood horse populations. J Vet Intern Med 2015 Jan;29(1):320-6.
- Klumplerova M, Vychodilova L, Bobrova O, Cvanova M, Futas J, Janova E, Vyskocil M, Vrtkova I, Putnova L, Dusek L, Marti E, Horin P. Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses. Mol Biol Rep 2013 Apr;40(4):3333-40.
- Schurink A, Wolc A, Ducro BJ, Frankena K, Garrick DJ, Dekkers JC, van Arendonk JA. Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands. Genet Sel Evol 2012 Oct 30;44(1):31.
- Moran G, Folch H, Henriquez C, Ortloff A, Barria M. Reaginic antibodies from horses with recurrent airway obstruction produce mast cell stimulation. Vet Res Commun 2012 Dec;36(4):251-8.
- Andersson LS, Swinburne JE, Meadows JR, Broström H, Eriksson S, Fikse WF, Frey R, Sundquist M, Tseng CT, Mikko S, Lindgren G. The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations. Immunogenetics 2012 Mar;64(3):201-8.
- Morán G, Folch H, Araya O, Burgos R, Barria M. Detection of reaginic antibodies against Faenia rectivirgula from the serum of horses affected with Recurrent Airway Obstruction by an in vitro bioassay. Vet Res Commun 2010 Dec;34(8):719-26.
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