Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004.
Abstract: Amongst the infectious diseases that threaten equine health, herpesviral infections remain a world wide cause of serious morbidity and mortality. Equine herpesvirus-1 infection is the most important pathogen, causing an array of disorders including epidemic respiratory disease abortion, neonatal foal death, myeloencephalopathy and chorioretinopathy. Despite intense scientific investigation, extensive use of vaccination, and established codes of practice for control of disease outbreaks, infection and disease remain common. While equine herpesvirus-1 infection remains a daunting challenge for immunoprophylaxis, many critical advances in equine immunology have resulted in studies of this virus, particularly related to MHC-restricted cytotoxicity in the horse. A workshop was convened in San Gimignano, Tuscany, Italy in June 2004, to bring together clinical and basic researchers in the field of equine herpesvirus-1 study to discuss the latest advances and future prospects for improving our understanding of these diseases, and equine immunity to herpesviral infection. This report highlights the new information that was the focus of this workshop, and is intended to summarize this material and identify the critical questions in the field.
Publication Date: 2006-03-20 PubMed ID: 16542736DOI: 10.1016/j.vetimm.2006.01.004Google Scholar: Lookup
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- Journal Article
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- Non-U.S. Gov't
- Review
Summary
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The research article abstract discusses the challenges and developments in understanding and controlling the spread of equine herpesvirus-1 (EHV-1), a prevalent and deadly disease in horses. It highlights the importance and findings of an international workshop held in Italy, where leading researchers gathered to discuss advances in equine immunology studies and future possibilities to improve understanding of these diseases.
Significance of the Equine Herpesvirus-1
- The article emphasizes the seriousness of equine herpesvirus-1 infection among horses, which can cause a range of health issues including respiratory disease, abortion, neonatal foal death, myeloencephalopathy, and chorioretinopathy. The virus is considered significant due to its global presence, severe morbidity and mortality rates.
- Despite substantial scientific investigation, vaccination programs and disease control practices, EHV-1 remains a persistent issue. This underscores the need for further research and innovation in managing the disease.
The Havermeyer Workshop
- A workshop was held in June 2004 in San Gimignano, Tuscany, where experts came together to discuss the future of equine herpesvirus-1 research. Participants shared new information and took a close look at each others’ work and advancements in the field.
- The meeting intended to improve the understanding of equine immunity to herpesviral infection. The emphasis was placed on how breakthroughs in equine immunology, particularly in studies related to MHC-restricted cytotoxicity in the horse, could contribute to immunoprophylaxis approaches to EHV-1.
Novelties and Future Directions
- The abstract highlights that the workshop brought forward new information on the EHV-1 issue, likely in terms of its biology, immunology, control, and treatment strategies. It asserts that the information derived from the gathering can guide future research, policies, and practices in the field.
- Although the abstract itself does not offer detail on specific discoveries or learnings from the meeting, it proposes that these insights will help define critical questions for further exploration in the study of the EHV-1 virus.
Cite This Article
APA
Slater JD, Lunn DP, Horohov DW, Antczak DF, Babiuk L, Breathnach C, Chang YW, Davis-Poynter N, Edington N, Ellis S, Foote C, Goehring L, Kohn CW, Kydd J, Matsumura T, Minke J, Morley P, Mumford J, Neubauer T, O'Callaghan D, Osterrieder K, Reed S, Smith K, Townsend H, van der Meulen K, Whalley M, Wilson WD.
(2006).
Report of the equine herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004.
Vet Immunol Immunopathol, 111(1-2), 3-13.
https://doi.org/10.1016/j.vetimm.2006.01.004 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, Hertfordshire AL9 7TA, UK. jslater@rvc.ac.uk
MeSH Terms
- Animals
- Herpesviridae Infections / immunology
- Herpesviridae Infections / prevention & control
- Herpesviridae Infections / veterinary
- Herpesviridae Infections / virology
- Herpesvirus 1, Equid
- Horse Diseases / immunology
- Horse Diseases / prevention & control
- Horse Diseases / virology
- Horses
Citations
This article has been cited 5 times.- Stasiak K, Dunowska M, Rola J. Outbreak of equid herpesvirus 1 abortions at the Arabian stud in Poland.. BMC Vet Res 2020 Oct 6;16(1):374.
- Lecollinet S, Pronost S, Coulpier M, Beck C, Gonzalez G, Leblond A, Tritz P. Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?. Viruses 2019 Dec 24;12(1).
- Said A, Azab W, Damiani A, Osterrieder N. Equine herpesvirus type 4 UL56 and UL49.5 proteins downregulate cell surface major histocompatibility complex class I expression independently of each other.. J Virol 2012 Aug;86(15):8059-71.
- Smith KL, Li Y, Breheny P, Cook RF, Henney PJ, Sells S, Pronost S, Lu Z, Crossley BM, Timoney PJ, Balasuriya UB. New real-time PCR assay using allelic discrimination for detection and differentiation of equine herpesvirus-1 strains with A2254 and G2254 polymorphisms.. J Clin Microbiol 2012 Jun;50(6):1981-8.
- Garré B, Shebany K, Gryspeerdt A, Baert K, van der Meulen K, Nauwynck H, Deprez P, De Backer P, Croubels S. Pharmacokinetics of acyclovir after intravenous infusion of acyclovir and after oral administration of acyclovir and its prodrug valacyclovir in healthy adult horses.. Antimicrob Agents Chemother 2007 Dec;51(12):4308-14.
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