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Home / Equine Research Bank / Can Vet J / Response to thyrotropin-releasing hormone (TRH) in a horse w...
The Canadian veterinary journal = La revue veterinaire canadienne2019; 60(11); 1189-1193;

Response to thyrotropin-releasing hormone (TRH) in a horse with hyperthyroidism associated with a functional thyroid adenoma.

Abstract: A 16-year-old American Paint Horse gelding was presented for evaluation of weight loss and high serum thyroid hormone concentrations resulting from a functional thyroid adenoma. The horse showed no response to a thyrotropin-releasing hormone (TRH) stimulation test. Clinical signs resolved following surgical removal of the adenoma. . Un cheval American Paint Horse hongre âgé de 16 ans fut présenté pour évaluation à la suite d’une perte de poids et d’une concentration sérique élevée d’hormone thyroïdienne résultant d’un adénome thyroïdien fonctionnel. Le cheval ne démontrait aucune réponse au test de stimulation de l’hormone relâchant la thyrotropine. Les signes cliniques se sont réglés après le retrait chirurgical de l’adénome.(Traduit par D Serge Messier).
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
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Publication Date: 2019-11-07 PubMed ID: 31692666PubMed Central: PMC6805031
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focused on an aged horse that exhibited symptoms of weight loss due to hyperthyroidism caused by a functional thyroid adenoma. The study shows that the horse’s condition improved after the adenoma was surgically removed.

Background and Aims

  • The research was directed towards a specific case of a 16-year-old American Paint Horse gelding.
  • The horse was experiencing severe weight loss and was identified to have high concentrations of thyroid hormone in its serum.
  • The primary aim of the study was to evaluate the cause of these symptoms and to consider the appropriate treatment.

Research Findings

  • The researchers conducted a thyrotropin-releasing hormone (TRH) stimulation test on the horse to ascertain its response to weight loss treatment efforts, but it showed no response.
  • The high serum thyroid hormone concentrations were identified as a result of a functional thyroid adenoma, a type of benign tumor in the thyroid gland.
  • The adenoma was significantly influencing the thyroid hormone levels, leading to an overactive thyroid (hyperthyroidism), thus explaining the excessive weight loss.

Treatment and Result

  • After identifying the cause, the functional thyroid adenoma was surgically removed to regularize the thyroid hormone levels.
  • Following the surgical intervention, the clinical signs previously exhibited by the horse like weight loss and high thyroid hormone concentration were found to have resolved, indicating successful treatment.

Cite This Article

APA
Costello J, Firshman AM, Brown JC, Maher M, Tadros EM. (2019). Response to thyrotropin-releasing hormone (TRH) in a horse with hyperthyroidism associated with a functional thyroid adenoma. Can Vet J, 60(11), 1189-1193.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 60
Issue: 11
Pages: 1189-1193

Researcher Affiliations

Costello, Jillian
  • Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Costello, Firshman, Brown, Maher); Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road Lansing, Michigan 48910, USA (Tadros).
Firshman, Anna M
  • Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Costello, Firshman, Brown, Maher); Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road Lansing, Michigan 48910, USA (Tadros).
Brown, Jennifer C
  • Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Costello, Firshman, Brown, Maher); Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road Lansing, Michigan 48910, USA (Tadros).
Maher, Michael
  • Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Costello, Firshman, Brown, Maher); Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road Lansing, Michigan 48910, USA (Tadros).
Tadros, Elizabeth M
  • Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Costello, Firshman, Brown, Maher); Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road Lansing, Michigan 48910, USA (Tadros).

MeSH Terms

  • Adenoma / veterinary
  • Animals
  • Horse Diseases
  • Horses
  • Hyperthyroidism / veterinary
  • Male
  • Thyroid Neoplasms / veterinary
  • Thyrotropin
  • Thyrotropin-Releasing Hormone

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Citations

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