Responsiveness of basophil granulocytes of horses suffering from chronic obstructive pulmonary disease to various allergens.
Abstract: As basophils are the major effector cells of allergic reactions, confirmation of the allergic etiology of chronic obstructive pulmonary disease (COPD) was sought by the demonstration of a specific in vitro response of equine basophilic blood cells to some potential allergens (Aspergillus, Cladosporidium, Mucor, Penicillium, extracts of dust particles of hay and straw). The allergen induced degranulation of basophils and the histamine and protease release from basophils during incubation with the allergens were tested. By evaluating the results obtained from 14 COPD horses and eight controls it could be shown that the sensitivity of the basophils of affected horses was increased, particularly against the allergen extract of Mucor mucedo and Mucor spinosus. Further a greater percentage of COPD horses reacted positively with the Mucor allergen extract. The mitogenic stimulation of lymphocytes by PHA and by the allergen extracts used gave comparable results in affected and control horses. Thus the in vitro stimulation of basophils may be an easily to perform testing device for the identification of potential allergens involved in the pathogenesis of equine COPD.
Publication Date: 1993-10-01 PubMed ID: 7507274DOI: 10.1016/0165-2427(93)90082-fGoogle Scholar: Lookup
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Cite This Article
APA
Dirscherl P, Grabner A, Buschmann H.
(1993).
Responsiveness of basophil granulocytes of horses suffering from chronic obstructive pulmonary disease to various allergens.
Vet Immunol Immunopathol, 38(3-4), 217-227.
https://doi.org/10.1016/0165-2427(93)90082-f Publication
Researcher Affiliations
- Institut für Medizinische Mikrobiologie, Universität München, Munich, Germany.
MeSH Terms
- Allergens / immunology
- Animals
- Basophil Degranulation Test / veterinary
- Basophils / immunology
- Female
- Histamine Release
- Horse Diseases / immunology
- Horses
- Hypersensitivity, Immediate / immunology
- Hypersensitivity, Immediate / veterinary
- Lung Diseases, Obstructive / immunology
- Lung Diseases, Obstructive / veterinary
- Lymphocyte Activation
- Male
Citations
This article has been cited 12 times.- Martins LML. Allergy to Fungi in Veterinary Medicine: Alternaria, Dermatophytes and Malassezia Pay the Bill!. J Fungi (Basel) 2022 Feb 27;8(3).
- White SJ, Moore-Colyer M, Marti E, Hannant D, Gerber V, Coüetil L, Richard EA, Alcocer M. Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Sci Rep 2019 Oct 23;9(1):15170.
- White S, Moore-Colyer M, Marti E, Coüetil L, Hannant D, Richard EA, Alcocer M. Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma. J Vet Intern Med 2019 Sep;33(5):2327-2335.
- Lavergne SN. In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine. Vet Sci 2016 Dec 22;4(1).
- Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ. Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease. J Vet Intern Med 2017 Jul;31(4):1193-1201.
- Mueller RS, Janda J, Jensen-Jarolim E, Rhyner C, Marti E. Allergens in veterinary medicine. Allergy 2016 Jan;71(1):27-35.
- Morán G, Burgos R, Araya O, Folch H. In vitro bioassay to detect reaginic antibodies from the serum of horses affected with recurrent airway obstruction. Vet Res Commun 2010 Jan;34(1):91-9.
- Hare JE, Viel L, Conlon PD, Marshall JS. Evaluation of an in vitro degranulation challenge procedure for equine pulmonary mast cells. Can J Vet Res 1998 Apr;62(2):133-9.
- Jentsch MC, Keilhaue A, Wagner B, Rhyner C, Lübke S, Karagulyan M, Arnold C, Lohmann KL, Schnabel CL. Aspergillus fumigatus binding IgA and IgG1 are increased in bronchoalveolar lavage fluid of horses with neutrophilic asthma. Front Immunol 2024;15:1406794.
- Jentsch MC, Lübke S, Schrödl W, Volke D, Krizsan A, Hoffmann R, Kaiser-Thom S, Gerber V, Marti E, Wagner B, Schnabel CL. Immunoproteomics enable broad identification of new Aspergillus fumigatus antigens in severe equine asthma. Front Immunol 2024;15:1347164.
- White SJ, Couetil L, Richard EA, Marti E, Wilson PB. Microarray molecular mapping of horses with severe asthma. J Vet Intern Med 2024 Jan-Feb;38(1):477-484.
- Martins LML. Survey of Sensitization to Common Fungi in an Allergic Dog Population: The Need for Further Focus on Sensitization and Allergy to Fungi in Veterinary Medicine. J Fungi (Basel) 2023 Nov 3;9(11).
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