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Home / Equine Research Bank / Neurosci Lett / Retinal astrocytes: their restriction to vascularized parts ...
Neuroscience letters1987; 78(1); 29-34; doi: 10.1016/0304-3940(87)90556-8

Retinal astrocytes: their restriction to vascularized parts of the mammalian retina.

Abstract: The distribution of astrocytes has been studied in whole-mounted horse and monkey retinae by the immunocytochemical localization of glial fibrillary acidic protein (GFAP). In the horse, astrocytes were found to be restricted to a narrow zone close to the optic nerve head. This is also the only region of the horse retina that is vascularized. In the monkey, astrocytes were found ubiquitously in the nerve fiber layer of the retina, apart from the avascular fovea centralis which lacked astrocytes. These observations strongly suggest that retinal astrocytes co-occur with blood vessels, a feature which may be common among mammals.
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Publication Date: 1987-07-09 PubMed ID: 3614770DOI: 10.1016/0304-3940(87)90556-8Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reports on the distribution of astrocytes (star-shaped cells in the central nervous system) in the retinal part of the eyes of horses and monkeys. The study presents evidence suggesting that these astrocytes are predominantly present in the vascularized (blood vessel-rich) sections of the retina.

Research Methodology:

  • The researchers used immunocytochemical methods to study the localization of the glial fibrillary acidic protein (GFAP), which is heavily expressed in astrocytes.
  • They analyzed the distribution of this protein in whole-mounted horse and monkey retinal specimens.

Findings in Horse Retinas:

  • In horses, astrocytes were found to be confined to a narrow zone close to the optic nerve head. This region is also notable because it’s the only part of the horse retina that is vascularized.

Findings in Monkey Retinas:

  • In monkeys, astrocytes were present throughout the nerve fiber layer of the retina. The only exception was the avascular fovea centralis, a small depression in the retina where vision is most acute, which lacks astrocytes.

General Implications:

  • These findings suggest a correlation between the presence of astrocytes and blood vessels in the retina, implying that the locations where astrocytes are found might be specific to vascularized parts.
  • This characteristic may be universal among mammals, presenting an intriguing area for further investigation in neurobiology and vision science.

Cite This Article

APA
Schnitzer J. (1987). Retinal astrocytes: their restriction to vascularized parts of the mammalian retina. Neurosci Lett, 78(1), 29-34. https://doi.org/10.1016/0304-3940(87)90556-8

Publication

Neuroscience letters
ISSN: 0304-3940
NlmUniqueID: 7600130
Country: Ireland
Language: English
Volume: 78
Issue: 1
Pages: 29-34

Researcher Affiliations

Schnitzer, J

    MeSH Terms

    • Animals
    • Astrocytes / cytology
    • Astrocytes / metabolism
    • Cercopithecus / anatomy & histology
    • Chlorocebus aethiops / anatomy & histology
    • Glial Fibrillary Acidic Protein / metabolism
    • Horses / anatomy & histology
    • Retina / cytology
    • Retina / metabolism
    • Species Specificity

    Citations

    This article has been cited 15 times.
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      doi: 10.1017/S1740925X06000202pubmed: 17356684google scholar: lookup
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      doi: 10.1172/JCI25964pubmed: 16424942google scholar: lookup
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      doi: 10.1007/BF00741450pubmed: 1723659google scholar: lookup
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