Safety and efficacy of the feed additive 4-methyl-5-vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl).
Abstract: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 4-methyl-5-vinylthiazole [15.018] belonging to chemical group 29 (thiazoles, thiophene and thiazoline), when used as sensory additive (flavourings) in feed for all animal species. The FEEDAP Panel concluded that 4-methyl-5-vinylthiazole [15.018] was safe at the maximum proposed use level of 0.5 mg/kg complete feed for veal calves (milk replacer), dogs, salmonids and ornamental fish. For the other species, the calculated safe concentrations in complete feed are: 0.4 mg/kg for cattle for fattening, sheep/goat, horses and cats; 0.3 mg/kg for sows and dairy cows; 0.2 mg/kg for piglets, pigs for fattening, rabbits and laying hens; and 0.1 mg/kg for chickens for fattening and turkeys for fattening. These conclusions were extrapolated to other physiologically related species. For any other species, the additive was considered safe at 0.1 mg/kg complete feed. No safety concern would arise for the consumer from the use the additive up to the maximum proposed use level in feed. The additive should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 4-methyl-5-vinylthiazole [15.018] as a flavour in animal feed was not expected to pose a risk to the environment. Since the compound under assessment is used in food as flavouring and its function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary.
© 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority.
Publication Date: 2023-06-07 PubMed ID: 37293568PubMed Central: PMC10245293DOI: 10.2903/j.efsa.2023.8051Google Scholar: Lookup
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Summary
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The article details a study conducted by the European Food Safety Authority (EFSA) on the safety and effectiveness of using a flavouring additive known as 4-methyl-5-vinylthiazole [15.018] in feed for all animal species. The EFSA panel found that at the maximum proposed usage levels the additive is safe, it won’t harm consumers, but it could cause skin, eye, and respiratory irritation for those handling it.
Research Methodology and Result
- The EFSA was tasked to study the safety and efficacy of the flavoring additive, 4-methyl-5-vinylthiazole [15.018] belonging to chemical group 29, as part of a request from the European Commission.
- The additive was examined for use in feed for all animal species. The research concluded that the additive was safe in specific use levels varying per species.
- The maximum proposed use level that was determined as safe was 0.5 mg/kg of complete feed for certain species such as veal calves, dogs, salmonids and ornamental fish.
- For other species like cattle, sheep, goats, horses, and cats, the safe concentration of the additive calculated in complete feed was 0.4 mg/kg. Sows and dairy cows were safe at 0.3 mg/kg, piglets, pigs for fattening, rabbits and laying hens at 0.2 mg/kg, and chickens and turkeys for fattening at 0.1 mg/kg.
- This research further extrapolated the science to other physiologically related species and concluded that for any other species the additive should be safe at 0.1 mg/kg complete feed.
Implications on Human Health and Environment
- From a consumer perspective, the additive posed no safety concern when used up to the highest suggested use level in animal feed.
- However, the report suggests that the additive could be an irritant to skin, eyes, and the respiratory tract for those handling it directly, suggesting the need for caution in its manipulation and usage.
- With respect to the environment, the use of the flavoring additive 4-methyl-5-vinylthiazole [15.018] was not expected to pose a risk.
Efficacy of the Additive
- Since the additive is already used in human food as a flavoring, the research did not find a need to further prove its efficacy for usage in animal feed. The assumption is based on the idea that the additive’s function in feed is the same as that in food.
The study thus concludes that the additive is basically safe for its proposed use, provided appropriate limits are maintained according to the specific animal species consuming the feed. Further, adequate safety measures should be taken while handling the additive to avoid skin, eye, and respiratory irritation in handler.
Cite This Article
APA
Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Dusemund B.
(2023).
Safety and efficacy of the feed additive 4-methyl-5-vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl).
EFSA J, 21(6), e08051.
https://doi.org/10.2903/j.efsa.2023.8051 Publication
Researcher Affiliations
References
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