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Veterinary sciences2020; 7(4); 178; doi: 10.3390/vetsci7040178

Sarcolipin Exhibits Abundant RNA Transcription and Minimal Protein Expression in Horse Gluteal Muscle.

Abstract: Ca regulation in equine muscle is important for horse performance, yet little is known about this species-specific regulation. We reported recently that horse encode unique gene and protein sequences for the sarcoplasmic reticulum (SR) Ca-transporting ATPase (SERCA) and the regulatory subunit sarcolipin (SLN). Here we quantified gene transcription and protein expression of SERCA and its inhibitory peptides in horse gluteus, as compared to commonly-studied rabbit skeletal muscle. RNA sequencing and protein immunoblotting determined that horse gluteus expresses the gene (SERCA1) as the predominant SR Ca-ATPase isoform and the gene as the most-abundant SERCA inhibitory peptide, as also found in rabbit skeletal muscle. Equine muscle expresses an insignificant level of phospholamban (PLN), another key SERCA inhibitory peptide expressed commonly in a variety of mammalian striated muscles. Surprisingly in horse, the RNA transcript ratio of -to- is an order of magnitude than in rabbit, while the corresponding protein expression ratio is an order of magnitude than in rabbit. Thus, is not efficiently translated or maintained as a stable protein in horse muscle, suggesting a non-coding role for supra-abundant mRNA. We propose that the lack of SLN and PLN inhibition of SERCA activity in equine muscle is an evolutionary adaptation that potentiates Ca cycling and muscle contractility in a prey species domestically selected for speed.
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Publication Date: 2020-11-13 PubMed ID: 33202832PubMed Central: PMC7711957DOI: 10.3390/vetsci7040178Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper investigates the regulation of calcium in horse muscle and its importance for horse performance. It suggests that there may be an evolutionary adaptation in horses, involving limited inhibition of muscle contractility, to increase speed.

Background

  • The study notes the importance of calcium regulation in equine muscle for horse performance. It further acknowledges a gap in specific understanding about this species-specific regulation.

Previous Findings

  • The researchers had previously reported that the horse genome encodes unique gene and protein sequences for the sarcoplasmic reticulum (SR) calcium-transporting ATPase (SERCA) and the regulatory subunit sarcolipin (SLN).

Current Study

  • The current study quantifies gene transcription and protein expression of SERCA and its inhibitory peptides in horse gluteus, comparing it to widely-studied rabbit skeletal muscle.

Methodology and Results

  • RNA sequencing and protein immunoblotting were employed to determine the expressions of SERCA and its inhibitory peptides. The horse gluteus was found to express the SERCA1 gene as the predominant SR calcium-ATPase isoform and the SLN gene as the most-abundant SERCA inhibitory peptide – characteristics similar to those found in rabbit skeletal muscle.
  • However, the horse muscle was found to express a negligible level of phospholamban (PLN), another key SERCA inhibitory peptide, usually found in various mammalian striated muscles.
  • The research reveals a surprising finding that in horse muscle, the RNA transcript ratio of SLN-to-SERCA1 is much higher than in rabbit, while the corresponding protein expression ratio is much lower. This suggests that the SLN is not efficiently translated or maintained as a stable protein in horse muscle, implying a non-coding role for the abundant SLN mRNA.

Conclusion and Hypothesis

  • This article asserts that the lack of SLN and PLN inhibition of SERCA activity in equine muscle is perhaps an evolutionary adaptation. This adaptation would increase calcium cycling and muscle contractility, which could be favorable traits for a prey species that has been selectively bred for speed.

Cite This Article

APA
Autry JM, Karim CB, Perumbakkam S, Finno CJ, McKenzie EC, Thomas DD, Valberg SJ. (2020). Sarcolipin Exhibits Abundant RNA Transcription and Minimal Protein Expression in Horse Gluteal Muscle. Vet Sci, 7(4), 178. https://doi.org/10.3390/vetsci7040178

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 7
Issue: 4
PII: 178

Researcher Affiliations

Autry, Joseph M
  • Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Karim, Christine B
  • Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Perumbakkam, Sudeep
  • Department of Large Animal Clinical Sciences, McPhail Equine Performance Center, Michigan State University, East Lansing, MI 48823, USA.
Finno, Carrie J
  • Department of Population Health and Reproduction, University of California, Davis, CA 95616, USA.
McKenzie, Erica C
  • Department of Clinical Sciences, Oregon State University, Corvallis, OR 97331, USA.
Thomas, David D
  • Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Valberg, Stephanie J
  • Department of Large Animal Clinical Sciences, McPhail Equine Performance Center, Michigan State University, East Lansing, MI 48823, USA.

Grant Funding

  • HL139065 / NIH HHS
  • R37 AG026160 / NIA NIH HHS
  • GM27906 / NIH HHS
  • R01 HL139065 / NHLBI NIH HHS
  • D16EQ-004 / Morris Animal Foundation
  • D14EQ-021 / Morris Animal Foundation
  • AG26160 / NIH HHS
  • R01 AG026160 / NIA NIH HHS

Conflict of Interest Statement

The authors declare that they have no competing interests with the contents of this article. S.J.V. is part-owner of the license for genetic testing of equine type 1 polysaccharide storage myopathy, glycogen branching enzyme deficiency, receiving sales income from their diagnostic use. S.J.V. also receives royalties from the sale of Re-Leve equine feed. The financial and business interests of S.J.V. have been reviewed and managed by Michigan State University in accordance with MSU conflict of interest policies. D.D.T. holds equity in and serves as an executive officer for Photonic Pharma, L.L.C. The financial and business interests of D.D.T. have been reviewed and managed by the University of Minnesota in accordance with UMN conflict of interest policies. Photonic Pharma, L.L.C., had no role in this study.

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Citations

This article has been cited 1 times.
  1. Autry JM, Svensson B, Carlson SF, Chen Z, Cornea RL, Thomas DD, Valberg SJ. Sarcoplasmic Reticulum from Horse Gluteal Muscle Is Poised for Enhanced Calcium Transport. Vet Sci 2021 Nov 23;8(12).
    doi: 10.3390/vetsci8120289pubmed: 34941816google scholar: lookup
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